Results 81 to 90 of about 782,650 (299)
RNA modification of an RNA modifier prevents self-RNA sensing
PLOS Biology, 2021 A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 ...
Daltry L. Snider, Stacy M. Horner
openaire +4 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Targeted genome modifications in soybean with CRISPR/Cas9 [PDF]
, 2015 Background: The ability to selectively alter genomic DNA sequences in vivo is a powerful tool for basic and applied research. The CRISPR/Cas9 system precisely mutates DNA sequences in a number of organisms.
Jacobs, Thomas +3 more
core +2 more sources
Quantitative Analysis of RNA Modifications [PDF]
, 2010 RNA modifications impact numerous cellular processes such as pre-mRNA splicing and protein synthesis. The elucidation of the mechanisms by which these modifications impact cellular processes necessitates the ability to both detect and quantify the presence of these modifications within RNA molecules.
John, Karijolich +2 more
openaire +2 more sources
The 2'-5' RNA Ligase of Escherichia coli: Purification, Cloning, and Genomic Disruption [PDF]
, 1996 An RNA ligase previously detected in extracts of Escherichia coli is capable of joining Saccharomyces cerevisiae tRNA splicing intermediates in the absence of ATP to form a 2-5 phosphodiester linkage (Greer, C., Javor, B., and Abelson, J. (1983) Cell 33,
Abelson, John N., Arn, Eric A.
core
Defining the chromatin signature of inducible genes in T cells [PDF]
, 2016 BACKGROUND Specific chromatin characteristics, especially the modification status of the core histone proteins, are associated with active and inactive genes. There is growing evidence that genes that respond to environmental or developmental signals may
Bunting, Karen +6 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
RNA modifications and cancer ferroptosis
Cancer Cell InternationalIn recent years, cancer treatment has faced significant challenges, highlighting the urgent need for novel therapeutic strategies. Ferroptosis is a regulated type of cellular demise that is distinguished by lipid peroxidation reliant on iron.
Yingda Xie +8 more
doaj +1 more source
Emerging Roles and Mechanisms of RNA Modifications in Neurodegenerative Diseases and Glioma
CellsDespite a long history of research, neurodegenerative diseases and malignant brain tumor gliomas are both considered incurable, facing challenges in the development of treatments.
Ami Kobayashi +5 more
doaj +1 more source