Results 61 to 70 of about 782,650 (299)

mRNA Regulation by RNA Modifications

Annual Review of Biochemistry, 2023
Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth. mRNA modifications have been demonstrated to influence nearly every step from the early phases of transcript ...
Gilbert, Wendy V., Nachtergaele, Sigrid
openaire   +2 more sources

The regulation of antiviral innate immunity through non-m6A RNA modifications

Frontiers in Immunology, 2023
The post-transcriptional RNA modifications impact the dynamic regulation of gene expression in diverse biological and physiological processes. Host RNA modifications play an indispensable role in regulating innate immune responses against virus infection
Shenghai Shen, Li-Sheng Zhang, Li-Sheng Zhang   +2 more
doaj   +1 more source

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. [PDF]

, 2019
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA).
Blanchard, Scott C, Calvert, Meredith E, Chen, Bin, Contreras, Adrian, Forester, Craig M, Gill, Ryan M, Gordan, John D, Holm, Mikael, Jackson, Cody, Kelley, R Kate, Luk, John M, McMahon, Mary, Pang, Xiaming, Quigley, David A, Ruggero, Davide, Uechi, Tamayo   +15 more
core   +1 more source

Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer [PDF]

, 2014
The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to differences in target specificity.
Ailan Guo, Bild, Cai, Carstens, Carvalho, Chen, Chen, Cho, Christos Polytarchou, Conrad, Cooper, Dimitrios Iliopoulos, Duina, Ezell, Filippos Kottakis, Franke, Gowher, Iliopoulos, Ioannis Sanidas, Jianxin Xie, Kalsotra, Kolasinska-Zwierz, Kottakis, Krogan, Kumar, Lan Hu, Luco, Luco, Manning, Maria Hatziapostolou, Maroulakou, Michael J. Comb, Miki, Moore, Moshkin, Orr-Urtreger, Peña, Philip N. Tsichlis, Polytarchou, Scott A. Ezell, Thiery, Tschopp, Wan, Wang, Warzecha, Xie, Yoh, Yoh, Zhang, Zhou   +49 more
core   +1 more source

RNA Modification in Metabolism

MedComm
ABSTRACTEpigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and the most prevalent modification in RNA is N6‐methyladenosine (m6A). Recently, RNA modification has emerged as a potential target for disease treatment.
Yadi Liu, Zhongyan Sun, Dingkun Gui, Yonghua Zhao, Youhua Xu   +4 more
openaire   +3 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

m6a RNA methylation: the implications for health and disease [PDF]

, 2014
The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

RNA modification in Cajal bodies [PDF]

RNA Biology, 2016
Aside from nucleoli, Cajal bodies (CBs) are the best-characterized organelles of mammalian cell nuclei. Like nucleoli, CBs concentrate ribonucleoproteins (RNPs), in particular, spliceosomal small nuclear RNPs (snRNPs) and small nucleolar RNPs (snoRNPs).
openaire   +2 more sources