Results 101 to 110 of about 503,240 (288)
RNA modifications in the tumor microenvironment: insights into the cancer-immunity cycle and beyond
Experimental Hematology & OncologyThe chemical modification of biological molecules is a critical regulatory mechanism for controlling molecular functions. Although research has long focused on DNA and proteins, RNA modifications have recently attracted substantial interest with the ...
You-Peng Ding, Cui-Cui Liu, Ke-Da Yu
doaj +1 more source
RNA Modifications in Osteoarthritis: Epitranscriptomic Insights into Pathogenesis and Therapeutic Targets. [PDF]
Int J Mol SciOsteoarthritis (OA) is a chronic joint disorder characterized by progressive degeneration of articular cartilage, pain, synovial inflammation, and bone remodeling.
Radbakhsh S +7 more
europepmc +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Above the Epitranscriptome: RNA Modifications and Stem Cell Identity [PDF]
, 2018 Sequence databases and transcriptome-wide mapping have revealed different reversible and dynamic chemical modifications of the nitrogen bases of RNA molecules.
Francesco Morena +9 more
core +1 more source
Journal of Clinical and Translational ScienceObjectives/Goals: To date, no study has jointly profiled RNA isoforms and modifications associated with Alzheimer’s disease neuropathological changes (ADNC) in a human cohort. Therefore, the overall objective of this study is to identify and characterize
Grant Fox +4 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders
Frontiers in Bioengineering and Biotechnology, 2018 Analogous to DNA methylation and histone modifications, RNA modifications represent a novel layer of regulation of gene expression. The dynamic nature and increasing number of RNA modifications offer new possibilities to rapidly alter gene expression ...
Margarita T. Angelova +6 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Roles of RNA Modifications in Regulating Chloroplast Performance and Photosynthesis Efficiency [PDF]
The regulation of gene expression is crucial for maintaining cellular activities and responding to environmental stimuli. RNA molecules are central to this regulatory network, influencing transcription, post-transcriptional processing, and translation ...
Robert Luciński, Małgorzata Adamiec
core +1 more source
Rationalizing the effects of RNA modifications on protein interactions
Molecular Therapy: Nucleic AcidsRNA modifications play a crucial role in regulating gene expression by altering RNA structure and modulating interactions with RNA-binding proteins (RBPs).
Andrea Vandelli +4 more
doaj +1 more source