Results 1 to 10 of about 1,745,918 (176)

Identification of molecular subtypes based on pseudouridine modification in hepatocellular carcinoma

Cancer Cell International
Hepatocellular carcinoma (HCC) is a highly aggressive disease with a dismal prognosis. The recently described role of RNA pseudouridine modification in regulating anti-tumor immunity has attracted interest, but the understanding of its impact on ...
Weifeng Xu, Caiyun Nie, Zhen Liu, Yingjun Liu, Penghui Yu, Huifang Lv, Beibei Chen, Jianzheng Wang, Saiqi Wang, Jing Zhao, Yunduan He, Shegan Gao, Xiaobing Chen   +12 more
doaj   +1 more source

PseUpred-ELPSO Is an Ensemble Learning Predictor with Particle Swarm Optimizer for Improving the Prediction of RNA Pseudouridine Sites

Biology
RNA pseudouridine modification exists in different RNA types of many species, and it has a significant role in regulating the expression of biological processes.
Xiao Wang, Pengfei Li, Rong Wang, Xu Gao
doaj   +1 more source

Urinary pseudouridine excretion in myelomatosis [PDF]

British Journal of Cancer, 1985
Urinary psi excretion is independent of the main indices of tumour activity in myelomatosis (serum paraprotein, serum beta 2-microglobulin, serum creatinine and urinary light chain production). The mean (+/- s.d.) psi at presentation was 40.7 +/- 22.6 nmol. mumol ucr-1, compared to 25.4 +/- 4.8 nmol. mumol ucr-1 in controls.
S H, Sørensen, D A, Brown, E H, Cooper, K A, Kelly, I C, MacLennan   +4 more
openaire   +2 more sources

Epitranscriptomic signatures in blood: emerging biomarkers for diagnosis of diabetes and its complications

Frontiers in Cell and Developmental Biology
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and progressive β-cell dysfunction.
Marketa Hlavackova, Daniel Benak, Kristyna Holzerova, Petra Alanova, Jaroslav Hrdlicka, Miloslava Chalupova, Barbora Opletalova, Bohuslav Ostadal, Frantisek Kolar   +8 more
doaj   +1 more source

An investigation into eukaryotic pseudouridine synthases [PDF]

Journal of Bioinformatics and Computational Biology, 2014
A common post-transcriptional modification of RNA is the conversion of uridine to its isomer pseudouridine. We investigated the biological significance of eukaryotic pseudouridine synthases using the yeast Saccharomyces cerevisiae. We conducted a comprehensive statistical analysis on growth data from automated perturbation (gene deletion) experiments,
Ross D. King, Chuan Lu
openaire   +2 more sources

N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs

Scientific Reports, 2022
AbstractIn vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N1-methyl-pseudouridine (m1Ψ), are incorporated in the synthetic mRNA.
Tien-Hao Chen, Vladimir Potapov, Nan Dai, Jennifer L. Ong, Bijoyita Roy   +4 more
openaire   +3 more sources

Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches

Molecular Therapy: Nucleic Acids, 2019
mRNA therapeutics hold great promise for the treatment of human diseases. While incorporating naturally occurring modified nucleotides during synthesis has greatly increased their potency and safety, challenges in selective expression have hindered ...
John Lockhart, John Canfield, Ezinne Francess Mong, Jeffrey VanWye, Hana Totary-Jain   +4 more
doaj   +1 more source

Guide snoRNAs: Drivers or Passengers in Human Disease?

Biology, 2018
In every domain of life, RNA-protein interactions play a significant role in co- and post-transcriptional modifications and mRNA translation. RNA performs diverse roles inside the cell, and therefore any aberrancy in their function can cause various ...
Manisha Deogharia, Mrinmoyee Majumder
doaj   +1 more source

Definer: A computational method for accurate identification of RNA pseudouridine sites based on deep learning.

PLoS ONE
Pseudouridine is an important modification site, which is widely present in a variety of non-coding RNAs and is involved in a variety of important biological processes.
Bo Han, Sudan Bai, Yang Liu, Jiezhang Wu, Xin Feng, Ruihao Xin   +5 more
doaj   +1 more source

Identification of RNA pseudouridine sites using deep learning approaches.

PLoS ONE, 2021
Pseudouridine(Ψ) is widely popular among various RNA modifications which have been confirmed to occur in rRNA, mRNA, tRNA, and nuclear/nucleolar RNA. Hence, identifying them has vital significance in academic research, drug development and gene therapies.
Abu Zahid Bin Aziz, Md Al Mehedi Hasan, Jungpil Shin   +2 more
doaj   +1 more source