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Systematic metabolic engineering of Escherichia coli for high-level production of pseudouridine via pathway optimization and precursor enhancement [PDF]
Synthetic and Systems BiotechnologyPseudouridine, the C5-ribose epimer of uridine with significant biological functions and clinical applications, was efficiently produced through systematic metabolic strategy of Escherichia coli in this study.
Jing Song +6 more
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iPseU-CNN: Identifying RNA Pseudouridine Sites Using Convolutional Neural Networks
Molecular Therapy - Nucleic Acids, 2019 Pseudouridine is the most prevalent RNA modification and has been found in both eukaryotes and prokaryotes. Currently, pseudouridine has been demonstrated in several kinds of RNAs, such as small nuclear RNA, rRNA, tRNA, mRNA, and small nucleolar RNA ...
Hilal Tayara +2 more
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Advancements in pseudouridine modifying enzyme and cancer
Frontiers in Cell and Developmental BiologyPseudouridine (Ψ) is a post-transcriptional modifier of RNA, often referred to as the ‘fifth nucleotide’ owing to its regulatory role in various biological functions as well as because of its significant involvement in the pathogenesis of human cancer ...
Xinjun Hu, Xinyu Gu, Kaijie Liu
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Pseudouridine synthases upregulate 5′-tRF-Lys to inhibit YPEL3 and drive malignant progression in nasopharyngeal carcinoma [PDF]
Cellular & Molecular Biology LettersTransfer RNA-derived fragments (tRFs) are a recently discovered class of short noncoding RNAs widely distributed in various tissues and cell types. They are involved in the regulation of gene expression and play important roles in both physiological and ...
Daixi Ren +14 more
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Structure Characterization of Escherichia coli Pseudouridine Kinase PsuK
Frontiers in Microbiology, 2022 Pseudouridine (Ψ) is one of the most abundant RNA modifications in cellular RNAs that post-transcriptionally impact many aspects of RNA. However, the metabolic fate of modified RNA nucleotides has long been a question. A pseudouridine kinase (PsuK) and a
Xiaojia Li +7 more
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Frontiers in Cell and Developmental Biology, 2022 Aberrant expression of methyltransferases and demethylases may augment tumor initiation, proliferation and metastasis through RNA modification, such as m6A and m5C. However, activity of pseudouridine (Ψ) modification of RNA remains unknown in glioma, the
Lin-jian Wang +5 more
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The pivotal role of uridine modifications in the development of mRNA technology
Journal of Medical Science, 2023 In 2023, Katalin Karikó and Drew Weissman were awarded the Nobel Prize in Physiology or Medicine for their nucleoside base modifications research that later enabled mRNA vaccine development against COVID-19. This paper briefly reviews these achievements
Piotr Rzymski
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RNA Biology, 2022 Delicate variances in the translational machinery affect how efficiently different organisms approach protein synthesis. Determining the scale of this effect, however, requires knowledge on the differences of mistranslation levels.
Karl Jürgenstein +5 more
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Molecular Therapy: Nucleic Acids, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive single-stranded RNA virus, engages in complex interactions with host cell proteins throughout its life cycle. While these interactions enable the host to recognize and inhibit viral
Roberto Giambruno +16 more
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Dynamic regulation and key roles of ribonucleic acid methylation
Frontiers in Cellular Neuroscience, 2022 Ribonucleic acid (RNA) methylation is the most abundant modification in biological systems, accounting for 60% of all RNA modifications, and affects multiple aspects of RNA (including mRNAs, tRNAs, rRNAs, microRNAs, and long non-coding RNAs ...
Jia Zou +14 more
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