Results 1 to 10 of about 1,720,439 (181)

Systematic metabolic engineering of Escherichia coli for high-level production of pseudouridine via pathway optimization and precursor enhancement [PDF]

Synthetic and Systems Biotechnology
Pseudouridine, the C5-ribose epimer of uridine with significant biological functions and clinical applications, was efficiently produced through systematic metabolic strategy of Escherichia coli in this study.
Jing Song, Wei Shen, Yuanyuan Xia, Li Zhou, Yingjun Zhou, Haiquan Yang, Xianzhong Chen   +6 more
doaj   +2 more sources

iPseU-CNN: Identifying RNA Pseudouridine Sites Using Convolutional Neural Networks

Molecular Therapy - Nucleic Acids, 2019
Pseudouridine is the most prevalent RNA modification and has been found in both eukaryotes and prokaryotes. Currently, pseudouridine has been demonstrated in several kinds of RNAs, such as small nuclear RNA, rRNA, tRNA, mRNA, and small nucleolar RNA ...
Muhammad Tahir, Hilal Tayara, Kil To Chong   +2 more
exaly   +3 more sources

Molecular Insights into Widespread Pseudouridine RNA Modifications: Implications for Women’s Health and Disease [PDF]

Biology
Pseudouridine (Ψ), the most abundant RNA modification, plays essential roles in shaping RNA structure, stability, and translational output. Beyond cancer, Ψ is dynamically regulated across numerous physiological and pathological contexts—including immune
Qiwei Yang, Ayman Al-Hendy, Thomas G. Boyer   +2 more
doaj   +2 more sources

Pseudouridine synthases upregulate 5′-tRF-Lys to inhibit YPEL3 and drive malignant progression in nasopharyngeal carcinoma [PDF]

Cellular & Molecular Biology Letters
Transfer RNA-derived fragments (tRFs) are a recently discovered class of short noncoding RNAs widely distributed in various tissues and cell types. They are involved in the regulation of gene expression and play important roles in both physiological and ...
Daixi Ren, Mei Yang, Yongzhen Mo, Qijia Yan, Lei Shi, Shanshan Zhang, Zhaojian Gong, Can Guo, Ming Zhou, Bo Xiang, Ming Tan, Guiyuan Li, Pan Chen, Wei Xiong, Zhaoyang Zeng   +14 more
doaj   +2 more sources

Integrative analysis of nanopore direct RNA sequencing data reveals a global impact of pseudouridylation on m6A and m5C modifications [PDF]

npj Precision Oncology
RNA modifications play a crucial role in regulating cellular functions. Among the most abundant modifications in the human transcriptome are pseudouridine (Ψ), N6-methyladenosine (m6A), and 5-methylcytosine (m5C).
Mohit Bansal, Anamika Gupta, Jane Ding, Anirban Kundu, Katherine Marlow, Andrew Gibson, Zhangli Su, Sunil Sudarshan, Han-Fei Ding   +8 more
doaj   +2 more sources

Advancements in pseudouridine modifying enzyme and cancer

Frontiers in Cell and Developmental Biology
Pseudouridine (Ψ) is a post-transcriptional modifier of RNA, often referred to as the ‘fifth nucleotide’ owing to its regulatory role in various biological functions as well as because of its significant involvement in the pathogenesis of human cancer ...
Kaijie Liu, Liu Yafeng, Gu Xinyu
exaly   +3 more sources

Structure Characterization of Escherichia coli Pseudouridine Kinase PsuK

Frontiers in Microbiology, 2022
Pseudouridine (Ψ) is one of the most abundant RNA modifications in cellular RNAs that post-transcriptionally impact many aspects of RNA. However, the metabolic fate of modified RNA nucleotides has long been a question. A pseudouridine kinase (PsuK) and a
Xiaojia Li, Xiaojia Li, Kangjie Li, Wenting Guo, Yan Wen, Yan Wen, Chunyan Meng, Baixing Wu   +7 more
doaj   +1 more source

Gene Expression-Based Predication of RNA Pseudouridine Modification in Tumor Microenvironment and Prognosis of Glioma Patients

Frontiers in Cell and Developmental Biology, 2022
Aberrant expression of methyltransferases and demethylases may augment tumor initiation, proliferation and metastasis through RNA modification, such as m6A and m5C. However, activity of pseudouridine (Ψ) modification of RNA remains unknown in glioma, the
Lin-jian Wang, Lin-jian Wang, Peipei Lv, Yongli Lou, Jianping Ye, Jianping Ye   +5 more
doaj   +1 more source

Pseudouridines in spliceosomal snRNAs [PDF]

Protein & Cell, 2011
Spliceosomal RNAs are a family of small nuclear RNAs (snRNAs) that are essential for pre-mRNA splicing. All vertebrate spliceosomal snRNAs are extensively pseudouridylated after transcription. Pseudouridines in spliceosomal snRNAs are generally clustered in regions that are functionally important during splicing.
Andrew T, Yu, Junhui, Ge, Yi-Tao, Yu
openaire   +2 more sources

The pivotal role of uridine modifications in the development of mRNA technology

Journal of Medical Science, 2023
In 2023, Katalin Karikó and Drew Weissman were awarded the Nobel Prize in Physiology or Medicine for their nucleoside base modifications research that later enabled mRNA vaccine development against COVID-19. This paper briefly reviews these achievements
Piotr Rzymski
doaj   +1 more source