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Acylated uridine and cytidine for elevating tissue uridine and cytidine
1996VON BORSTEL REID, BAMAT MICHAEL K
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Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K/Akt–FoxO signaling [PDF]
BackgroundOsteoporosis is a metabolic bone disease characterized by dysregulated osteoclast activity, resulting in increased bone degradation and compromised bone microarchitecture.
Sijie Bian +19 more
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Uridine Improves Locomotor Activity and Sciatic Nerve Integrity in a Mouse Model of Diabetes Mellitus [PDF]
Diabetic peripheral neuropathy is an important cause of functional disability, and current therapies have limited ability to halt its progression.
Anca-Maria Țucă +10 more
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Uridine release during aminopyridine-induced epilepsy
Uridine, like adenosine, is released under sustained depolarization and it can inhibit hippocampal neuronal activity, suggesting that uridine may be released during seizures and can be involved in epileptic mechanisms.In an in vivo microdialysis study ...
Gabor Juhasz +2 more
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Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice [PDF]
Uridine is a pyrimidine nucleoside that exerts restorative functions in tissues under stress. Short-term co-administration of uridine with multiple unrelated drugs prevents drug-induced liver lipid accumulation.
Thuc Le, Yasuyo Urasaki
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The Role of Uridine in Health and Disease
Congkuan Song,1– 3 Zhen-Juan Liu,4 Bangjun Xu,5 Rui Zou,1,2 Weidong Hu1– 3 1Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Hubei Provincial Clinical Research Center for Cancer, Wuhan, People’s ...
Weidong Hu
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Indispensable residue for uridine binding in the uridine-cytidine kinase family
Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine. However, UCK of Thermus thermophilus HB8 (ttCK) phosphorylates only cytidine.
Fumiaki Tomoike +5 more
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The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear.
Rong Xu +7 more
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