Results 1 to 10 of about 78,467 (115)

Uridine Improves Locomotor Activity and Sciatic Nerve Integrity in a Mouse Model of Diabetes Mellitus. [PDF]

Biomolecules
Diabetic peripheral neuropathy is an important cause of functional disability, and current therapies have limited ability to halt its progression.
Țucă AM, Mitran SI, Burada E, Preda AN, Dan AO, Târtea EA, Greșiță A, Pană RC, Hădăreanu DR, Sfredel V, Târtea G.   +10 more
europepmc   +2 more sources

Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K/Akt-FoxO signaling. [PDF]

Front Immunol
BackgroundOsteoporosis is a metabolic bone disease characterized by dysregulated osteoclast activity, resulting in increased bone degradation and compromised bone microarchitecture.
Bian S, Zhao L, Wang X, Wu Z, Yang M, Ou J, Han T, Liao F, Xue Q, Huo X, Chang J.   +10 more
europepmc   +2 more sources

Uridine release during aminopyridine-induced epilepsy

Neurobiology of Disease, 2004
Uridine, like adenosine, is released under sustained depolarization and it can inhibit hippocampal neuronal activity, suggesting that uridine may be released during seizures and can be involved in epileptic mechanisms.In an in vivo microdialysis study ...
Gábor Juhász, Andrea Slézia, Tamás Freund   +2 more
exaly   +3 more sources

Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice [PDF]

PLoS ONE, 2016
Uridine is a pyrimidine nucleoside that exerts restorative functions in tissues under stress. Short-term co-administration of uridine with multiple unrelated drugs prevents drug-induced liver lipid accumulation.
Thuc T Le, Yasuyo Urasaki
exaly   +2 more sources

The Role of Uridine in Health and Disease

Journal of Inflammation Research
Congkuan Song,1– 3 Zhen-Juan Liu,4 Bangjun Xu,5 Rui Zou,1,2 Weidong Hu1– 3 1Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Hubei Provincial Clinical Research Center for Cancer, Wuhan, People’s ...
Congkuan Song, Weidong Hu
exaly   +2 more sources

Lactobacillus plantarum Ameliorates High-Carbohydrate Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress by Upregulating Uridine Synthesis

Antioxidants, 2022
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear.
Rong Xu, Tong Wang, Fei-Fei Ding, Nan-Nan Zhou, Fang Qiao, Li-Qiao Chen, Zhen-Yu Du, Mei-Ling Zhang   +7 more
doaj   +1 more source

LDL cholesterol and uridine levels in blood are potential nutritional biomarkers for clinical progression in Alzheimer's disease: The NUDAD project

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
INTRODUCTION We examined associations between nutritional biomarkers and clinical progression in individuals with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease (AD)‐type dementia.
Francisca A. deLeeuw, Betty M. Tijms, Astrid S. Doorduijn, Heleen M. A. Hendriksen, Ondine van deRest, Marian A. E. devan der Schueren, Marjolein Visser, Ellen G. H. M. vanden Heuvel, Nick vanWijk, Jörgen Bierau, Bart N. vanBerckel, Philip Scheltens, Maartje I. Kester, Wiesje M. van derFlier, Charlotte E. Teunissen   +14 more
doaj   +1 more source

A Treatable Genetic Disease Caused by CAD Mutation

Frontiers in Pediatrics, 2022
Type 50 early infantile epileptic encephalopathy, or EIEE-50 for short, is an autosomal recessive genetic disorder resulting from CAD mutations. So far, little has been reported on the disease.
Xia Peng, Li-ping Xia, Hai-ju Zhang, Jing Zhang, Shi-qian Yu, Shun Wang, Yu-ming Xu, Baozhen Yao, Jingping Ye   +8 more
doaj   +1 more source

Honey as Source of Nitrogen Compounds: Aromatic Amino Acids, Free Nucleosides and Their Derivatives

Molecules, 2020
The content of selected major nitrogen compounds including nucleosides and their derivatives was evaluated in 75 samples of seven varieties of honey (heather, buckwheat, black locust, goldenrod, canola, fir, linden) by targeted ultra-high performance ...
Piotr M. Kuś
doaj   +1 more source

Development of Diversified Methods for Chemical Modification of the 5,6-Double Bond of Uracil Derivatives Depending on Active Methylene Compounds

Molecules, 2012
The reaction of 5-halogenouracil and uridine derivatives <strong>1</strong> and <strong>7</strong> with active methylene compounds under basic conditions produced diverse and selective C-C bond formation products by virtue of the ...
Kosaku Hirota, Hideo Inoue, Yoshinari Sawama, Yoshifumi Maki, Yasunari Monguchi, Yukio Kitade, Kanoko Ikawa, Yusuke Iida, Hironao Sajiki   +8 more
doaj   +1 more source