Results 21 to 30 of about 78,517 (164)

An Open-label Randomized Crossover Study with Adaptive Design of the Pharmacokinetics and Bioequivalence of GP30121 and Ceraxon® Corrected for Endogenous Analyte Level

Разработка и регистрация лекарственных средств, 2023
Introduction. Citicoline is an endogenous nucleoside consisting of cytidine and choline linked by a diphosphate bridge that is involved in the synthesis of membrane phospholipids.
A. N. Arevefa, A. R. Dorotenko, S. M. Noskov, I. E. Makarenko, R. V. Drai, T. N. Komarov, O. A. Archakova, N. S. Bagaeva, I. E. Shokhin   +8 more
doaj   +1 more source

Uridine treatment protects against blood–brain barrier disruption in a rat model of Li-pilocarpine-induced status epilepticus

Frontiers in Neuroscience
IntroductionBlood–brain barrier (BBB) disruption is one of the most striking changes triggered by status epilepticus, which deserves specific attention in terms of novel treatment approaches targeting epileptogenesis.
Birnur Aydin, Busra Ocalan Esmerce, Aysen Cakir, Sueda Tuncak, Cansu Koc, Mehmet Cansev, Tulin Alkan   +6 more
doaj   +1 more source

Lycium barbarum polysaccharide suppresses uridine induced malignant progression of lung adenocarcinoma via UPP1 regulation

Cell Investigation
Lycium barbarum polysaccharide (LBP), derived from the fruit of Lycium chinense Mill., has been extensively studied for their potential health benefits in both dietary and medicinal contexts. Specifically, LBP exhibits various pharmacological properties,
Jingqin Chen, Qiuyin Huang, Congyan Hou, Jiao Liang, Jieying Guan, Sirou Chen, Xinyuan Wang, Ren Zhang, Yanli He   +8 more
doaj   +1 more source

Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

Molecules, 2013
New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were ...
Ilona Wandzik, Wiesław Szeja, Urszula Nawrot, Tadeusz Bieg, Katarzyna Kral, Jadwiga Paszkowska   +5 more
doaj   +1 more source

Liver uridine phosphorylase.

Acta physiologica latino americana, 1950
6 páginas en ...
Cardini, Carlos E., Paladini, Alejandro C., Caputto, Ranwel, Leloir, Luis Federico   +3 more
openaire   +3 more sources

Investigation of Uridine in Anti-Aging-Related Diseases Based on Network Pharmacology, Molecular Docking and Cell Experimental Validation

Engineered Science
There is currently only literature that verifies through in vivo experiments in animals that uridine can increase the metabolic level in mice, lacking research and validation on the anti-aging mechanism of uridine.
Haoxin Ma, Xiaowei Dai, Tao Wang, Zhongmei He, Rui Du, Hongyan Pei, Tianyuan Liu, Ruifen Sun, Kui Zhao   +8 more
doaj   +1 more source

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus

Molecules, 2019
Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system.
Ewelina Krol, Ilona Wandzik, Gabriela Brzuska, Luděk Eyer, Daniel Růžek, Boguslaw Szewczyk   +5 more
doaj   +1 more source

Differences in the Effectiveness of Uridine and Liriope platyphylla L. Between Complement Component 3 Deficiency- and Loperamide-Induced Constipation May Be Associated with the Alternative Regulation of the Cyclic Adenosine Monophosphate Downstream Signaling Pathway

Pharmaceuticals
Background/Objectives: Constipation can be induced in animal models through various factors such as loperamide (Lop) or complement component 3 (C3) deficiency.
Hee Jin Song, Eun Seo Park, Ji Eun Kim, Ayun Seol, Su Jeong Lim, Su Ha Wang, Ye Ryeong Kim, Ye Eun Ryu, So Hae Park, Jumin Park, Hyun Gu Kang, Dae Youn Hwang   +11 more
doaj   +1 more source

Uridine affects amino acid metabolism in sow-piglets model and increases viability of pTr2 cells

Frontiers in Nutrition, 2022
BackgroundAs an important nucleoside precursor in salvage synthesis pathway of uridine monophosphate, uridine (UR) is the most abundant nucleotide in sow milk.
Hong-ling Wang, Yilin Liu, Yilin Liu, Tiantian Zhou, Lumin Gao, Jianxi Li, Xin Wu, Xin Wu, Yu-long Yin, Yu-long Yin   +9 more
doaj   +1 more source

Synthesis of uridine derivatives

Communications, Faculty Of Science, University of Ankara Series B Chemistry and Chemical Engineering, 1992
2', 3'-0 isopropylidene-5-ammomethyl uridine was condensed with some aldehydes. in the şame time, reduçtion 44in situ” of the reaction products was achieved Ncvçrtheless, the resulting compounds showed to be unstable during chromatographic processes.
openaire   +2 more sources