Results 21 to 30 of about 75,343 (258)

mRNA Expression and Activity of Nucleoside Transporters in Human Hepatoma HepaRG Cells

Pharmaceutics, 2018
The HepaRG cell line is a highly differentiated human hepatoma cell line, displaying the expression of various drug transporters. However, functional expression of nucleoside transporters remains poorly characterized in HepaRG cells, although these ...
Abdullah Mayati, Amélie Moreau, Elodie Jouan, Marie Febvre-James, Claire Denizot, Yannick Parmentier, Olivier Fardel   +6 more
doaj   +1 more source

Identification of Major Antioxidant Compounds from the Edible Mushroom Basidiomycetes-X (Echigoshirayukidake)

Frontiers in Bioscience-Elite, 2022
Basidiomycetes-X, of which Japanese vernacular name is Echigoshirayukidake, is a local speciality mushroom found and cultivated in Japan that has been distributed as a precious cuisine material or as a functional food with medicinal properties ...
Toshio Sakamoto, Zhenshi Li, Ayaka Nishida, Asako Kadokawa, Takayuki Yoshida, Naoki Wada, Seiichi Matsugo, Yutaka Nakamura, Shinji Sato, Tetsuya Konishi   +9 more
doaj   +1 more source

From Formamide to RNA, the Path Is Tenuous but Continuous

Life, 2015
Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially
Samanta Pino, Judit E. Sponer, Giovanna Costanzo, Raffaele Saladino, Ernesto Di Mauro   +4 more
doaj   +1 more source

An Open-label Randomized Crossover Study with Adaptive Design of the Pharmacokinetics and Bioequivalence of GP30121 and Ceraxon® Corrected for Endogenous Analyte Level

Разработка и регистрация лекарственных средств, 2023
Introduction. Citicoline is an endogenous nucleoside consisting of cytidine and choline linked by a diphosphate bridge that is involved in the synthesis of membrane phospholipids.
A. N. Arevefa, A. R. Dorotenko, S. M. Noskov, I. E. Makarenko, R. V. Drai, T. N. Komarov, O. A. Archakova, N. S. Bagaeva, I. E. Shokhin   +8 more
doaj   +1 more source

A Patient With CAD Deficiency Responsive to Uridine and Literature Review

Frontiers in Neurology, 2020
CAD encodes a multifunctional enzyme involved in de novo pyrimidine biosynthesis, and pyrimidine can be alternatively recycled from uridine. Trio whole-exome sequencing identified CAD compound heterozygous mutations in a new male patient with global ...
Ling Zhou, Han Xu, Tianshuang Wang, Ye Wu   +3 more
doaj   +1 more source

Uridine treatment protects against blood–brain barrier disruption in a rat model of Li-pilocarpine-induced status epilepticus

Frontiers in Neuroscience
IntroductionBlood–brain barrier (BBB) disruption is one of the most striking changes triggered by status epilepticus, which deserves specific attention in terms of novel treatment approaches targeting epileptogenesis.
Birnur Aydin, Busra Ocalan Esmerce, Aysen Cakir, Sueda Tuncak, Cansu Koc, Mehmet Cansev, Tulin Alkan   +6 more
doaj   +1 more source

Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

Molecules, 2013
New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were ...
Ilona Wandzik, Wiesław Szeja, Urszula Nawrot, Tadeusz Bieg, Katarzyna Kral, Jadwiga Paszkowska   +5 more
doaj   +1 more source

Uridine affects amino acid metabolism in sow-piglets model and increases viability of pTr2 cells

Frontiers in Nutrition, 2022
BackgroundAs an important nucleoside precursor in salvage synthesis pathway of uridine monophosphate, uridine (UR) is the most abundant nucleotide in sow milk.
Hong-ling Wang, Yilin Liu, Yilin Liu, Tiantian Zhou, Lumin Gao, Jianxi Li, Xin Wu, Xin Wu, Yu-long Yin, Yu-long Yin   +9 more
doaj   +1 more source

Lycium barbarum polysaccharide suppresses uridine induced malignant progression of lung adenocarcinoma via UPP1 regulation

Cell Investigation
Lycium barbarum polysaccharide (LBP), derived from the fruit of Lycium chinense Mill., has been extensively studied for their potential health benefits in both dietary and medicinal contexts. Specifically, LBP exhibits various pharmacological properties,
Jingqin Chen, Qiuyin Huang, Congyan Hou, Jiao Liang, Jieying Guan, Sirou Chen, Xinyuan Wang, Ren Zhang, Yanli He   +8 more
doaj   +1 more source

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus

Molecules, 2019
Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system.
Ewelina Krol, Ilona Wandzik, Gabriela Brzuska, Luděk Eyer, Daniel Růžek, Boguslaw Szewczyk   +5 more
doaj   +1 more source