Results 21 to 30 of about 74,197 (237)

A Patient With CAD Deficiency Responsive to Uridine and Literature Review

Frontiers in Neurology, 2020
CAD encodes a multifunctional enzyme involved in de novo pyrimidine biosynthesis, and pyrimidine can be alternatively recycled from uridine. Trio whole-exome sequencing identified CAD compound heterozygous mutations in a new male patient with global ...
Ling Zhou, Han Xu, Tianshuang Wang, Ye Wu   +3 more
doaj   +1 more source

Liver uridine phosphorylase.

Acta physiologica latino americana, 1950
6 páginas en ...
Cardini, Carlos E., Paladini, Alejandro C., Caputto, Ranwel, Leloir, Luis Federico   +3 more
openaire   +3 more sources

Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

Molecules, 2013
New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were ...
Ilona Wandzik, Wiesław Szeja, Urszula Nawrot, Tadeusz Bieg, Katarzyna Kral, Jadwiga Paszkowska   +5 more
doaj   +1 more source

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus

Molecules, 2019
Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system.
Ewelina Krol, Ilona Wandzik, Gabriela Brzuska, Luděk Eyer, Daniel Růžek, Boguslaw Szewczyk   +5 more
doaj   +1 more source

Uridine affects amino acid metabolism in sow-piglets model and increases viability of pTr2 cells

Frontiers in Nutrition, 2022
BackgroundAs an important nucleoside precursor in salvage synthesis pathway of uridine monophosphate, uridine (UR) is the most abundant nucleotide in sow milk.
Hong-ling Wang, Yilin Liu, Yilin Liu, Tiantian Zhou, Lumin Gao, Jianxi Li, Xin Wu, Xin Wu, Yu-long Yin, Yu-long Yin   +9 more
doaj   +1 more source

Unexpected Seven-Membered Ring Formation for Muraymycin-Type Nucleoside-Peptide Antibiotics

Molbank, 2020
Naturally occurring nucleoside-peptide antibiotics such as muraymycins or caprazamycins are of major interest for the development of novel antibacterial agents.
Kristin Leyerer, Stefan Koppermann, Christian Ducho   +2 more
doaj   +1 more source

Case Report: Rapid Treatment of Uridine-Responsive Epileptic Encephalopathy Caused by CAD Deficiency

Frontiers in Pharmacology, 2020
We present two unrelated Chinese patients with CAD deficiency manifesting with a triad of infantile-onset psychomotor developmental delay with regression, drug-refractory epilepsy, and anaemia with anisopoikilocytosis.
Ling Zhou, Jie Deng, Sarah L. Stenton, Sarah L. Stenton, Ji Zhou, Hua Li, Chunhong Chen, Holger Prokisch, Holger Prokisch, Holger Prokisch, Fang Fang   +10 more
doaj   +1 more source

Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K/Akt–FoxO signaling

Frontiers in Immunology
BackgroundOsteoporosis is a metabolic bone disease characterized by dysregulated osteoclast activity, resulting in increased bone degradation and compromised bone microarchitecture.
Sijie Bian, Sijie Bian, Lianhui Zhao, Xu Wang, Xu Wang, Zhangwei Wu, Zhangwei Wu, Maolin Yang, Maolin Yang, Jianliang Ou, Jianliang Ou, Tao Han, Tao Han, Faxue Liao, Faxue Liao, Qingkai Xue, Xingxing Huo, Jun Chang, Jun Chang, Jun Chang   +19 more
doaj   +1 more source

Anti-Hepatitis C Virus Activity of Uridine Derivatives of 2-Deoxy Sugars

Molecules, 2018
Hepatitis C virus (HCV), the etiological agent of the most common and dangerous diseases of the liver, is a major health problem worldwide. Despite many attempts, there is still no vaccine available.
Ewelina Krol, Ilona Wandzik, Gabriela Pastuch-Gawolek, Boguslaw Szewczyk   +3 more
doaj   +1 more source

Differences in the Effectiveness of Uridine and Liriope platyphylla L. Between Complement Component 3 Deficiency- and Loperamide-Induced Constipation May Be Associated with the Alternative Regulation of the Cyclic Adenosine Monophosphate Downstream Signaling Pathway

Pharmaceuticals
Background/Objectives: Constipation can be induced in animal models through various factors such as loperamide (Lop) or complement component 3 (C3) deficiency.
Hee Jin Song, Eun Seo Park, Ji Eun Kim, Ayun Seol, Su Jeong Lim, Su Ha Wang, Ye Ryeong Kim, Ye Eun Ryu, So Hae Park, Jumin Park, Hyun Gu Kang, Dae Youn Hwang   +11 more
doaj   +1 more source