Results 21 to 30 of about 1,716 (122)

Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K/Akt–FoxO signaling

Frontiers in Immunology
BackgroundOsteoporosis is a metabolic bone disease characterized by dysregulated osteoclast activity, resulting in increased bone degradation and compromised bone microarchitecture.
Sijie Bian, Sijie Bian, Lianhui Zhao, Xu Wang, Xu Wang, Zhangwei Wu, Zhangwei Wu, Maolin Yang, Maolin Yang, Jianliang Ou, Jianliang Ou, Tao Han, Tao Han, Faxue Liao, Faxue Liao, Qingkai Xue, Xingxing Huo, Jun Chang, Jun Chang, Jun Chang   +19 more
doaj   +1 more source

Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

Molecules, 2013
New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were ...
Ilona Wandzik, Wiesław Szeja, Urszula Nawrot, Tadeusz Bieg, Katarzyna Kral, Jadwiga Paszkowska   +5 more
doaj   +1 more source

Uridine affects amino acid metabolism in sow-piglets model and increases viability of pTr2 cells

Frontiers in Nutrition, 2022
BackgroundAs an important nucleoside precursor in salvage synthesis pathway of uridine monophosphate, uridine (UR) is the most abundant nucleotide in sow milk.
Hong-ling Wang, Yilin Liu, Yilin Liu, Tiantian Zhou, Lumin Gao, Jianxi Li, Xin Wu, Xin Wu, Yu-long Yin, Yu-long Yin   +9 more
doaj   +1 more source

Lycium barbarum polysaccharide suppresses uridine induced malignant progression of lung adenocarcinoma via UPP1 regulation

Cell Investigation
Lycium barbarum polysaccharide (LBP), derived from the fruit of Lycium chinense Mill., has been extensively studied for their potential health benefits in both dietary and medicinal contexts. Specifically, LBP exhibits various pharmacological properties,
Jingqin Chen, Qiuyin Huang, Congyan Hou, Jiao Liang, Jieying Guan, Sirou Chen, Xinyuan Wang, Ren Zhang, Yanli He   +8 more
doaj   +1 more source

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus

Molecules, 2019
Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system.
Ewelina Krol, Ilona Wandzik, Gabriela Brzuska, Luděk Eyer, Daniel Růžek, Boguslaw Szewczyk   +5 more
doaj   +1 more source

Unexpected Seven-Membered Ring Formation for Muraymycin-Type Nucleoside-Peptide Antibiotics

Molbank, 2020
Naturally occurring nucleoside-peptide antibiotics such as muraymycins or caprazamycins are of major interest for the development of novel antibacterial agents.
Kristin Leyerer, Stefan Koppermann, Christian Ducho   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Investigation of Uridine in Anti-Aging-Related Diseases Based on Network Pharmacology, Molecular Docking and Cell Experimental Validation

Engineered Science
There is currently only literature that verifies through in vivo experiments in animals that uridine can increase the metabolic level in mice, lacking research and validation on the anti-aging mechanism of uridine.
Haoxin Ma, Xiaowei Dai, Tao Wang, Zhongmei He, Rui Du, Hongyan Pei, Tianyuan Liu, Ruifen Sun, Kui Zhao   +8 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Differences in the Effectiveness of Uridine and Liriope platyphylla L. Between Complement Component 3 Deficiency- and Loperamide-Induced Constipation May Be Associated with the Alternative Regulation of the Cyclic Adenosine Monophosphate Downstream Signaling Pathway

Pharmaceuticals
Background/Objectives: Constipation can be induced in animal models through various factors such as loperamide (Lop) or complement component 3 (C3) deficiency.
Hee Jin Song, Eun Seo Park, Ji Eun Kim, Ayun Seol, Su Jeong Lim, Su Ha Wang, Ye Ryeong Kim, Ye Eun Ryu, So Hae Park, Jumin Park, Hyun Gu Kang, Dae Youn Hwang   +11 more
doaj   +1 more source