RNA structural probing of guanine and uracil nucleotides in yeast. [PDF]
PLoS ONE, 2023 RNA structure can be essential for its cellular function. Therefore, methods to investigate the structure of RNA in vivo are of great importance for understanding the role of cellular RNAs.
Kevin Xiao +2 more
doaj +5 more sources
Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. [PDF]
J Pharmacol Exp Ther, 2013 The orphan receptor GPR17 has been reported to be activated by UDP, UDP-sugars, and cysteinyl leukotrienes, and coupled to intracellular Ca2+ mobilization and inhibition of cAMP accumulation, but other studies have reported either a different agonist profile or lack of agonist activity altogether.
Qi AD, Harden TK, Nicholas RA.
europepmc +5 more sources
Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides [PDF]
Trends in Pharmacological Sciences, 1989 Uridine and uracil nucleotides are involved in the regulation of various cell functions. Here, Roland Seifert and Günter Schultz review the evidence that, rather than by binding to purinoceptors, pyrimidine nucleotides exert their effects by binding to distinct pyrimidinoceptors, which are coupled to pertussis toxin-sensitive G proteins in human ...
Gunter Schultz
exaly +5 more sources
The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes [PDF]
Molecular Pharmacology, 2017 Pairing orphan G protein–coupled receptors (GPCRs) with their cognate endogenous ligands is expected to have a major impact on our understanding of GPCR biology. It follows that the reproducibility of orphan receptor ligand pairs should be of fundamental importance to guide meaningful investigations into the pharmacology and function of individual ...
Katharina Simon +12 more
semanticscholar +3 more sources
Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress. [PDF]
Biochemical Pharmacology, 2005 Cardiomyocytes express one or more subtypes of P2 receptors for extracellular nucleotides. P2 purinoceptors, which are activated by nucleotides, are classified as P2X or P2Y: P2X receptors are ligand-gated intrinsic ion channels, and P2Y receptors are G protein-coupled receptors.
Smadar Yitzhaki +3 more
semanticscholar +3 more sources
Genetic analysis of pyrimidine biosynthetic enzymes in Plasmodium falciparum. [PDF]
PLoS PathogensThe malaria parasite Plasmodium falciparum depends entirely on de novo pyrimidine synthesis, as it is unable to salvage these essential nucleotides. This reliance makes the pyrimidine biosynthesis pathway a compelling target for antimalarial drugs, with ...
Krithika Rajaram +6 more
doaj +2 more sources
Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes [PDF]
Journal of Cellular and Molecular Medicine, 2007 We previously showed that the human heart expresses all known P2X and P2Y receptors activated by extra‐cellular adenine or uracil nucleotides. Despite evidence that, both in humans and rodents, plasma levels of ATP and UTP markedly increase during ...
A. Mazzola +8 more
semanticscholar +3 more sources
The nucleobase analog 4-thiouracil hijacks the pyrimidine salvage pathway to inhibit Staphylococcus aureus growth [PDF]
Microbiology SpectrumStaphylococcus aureus is a leading cause of bacterial-induced mortality due to infections that are increasingly resistant to antibiotics, highlighting the need for new therapeutic strategies to treat these drug-resistant infections.
Matthew J. Munneke +2 more
doaj +2 more sources
Tools and drugs for uracil nucleotide‐activated P2Y receptors
Pharmacology & Therapeutics, 2018 P2Y receptors (P2YRs) are a family of G protein‐coupled receptors activated by extracellular nucleotides. Physiological P2YR agonists include purine and pyrimidine nucleoside di‐ and triphosphates, such as ATP, ADP, UTP, UDP, nucleotide sugars, and ...
Muhammad Rafehi, C. Müller
semanticscholar +5 more sources
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists
Bioorganic and Medicinal Chemistry, 2008 Kenneth A Jacobson +2 more
exaly +2 more sources