RNA structural probing of guanine and uracil nucleotides in yeast. [PDF]
PLoS ONE, 2023 RNA structure can be essential for its cellular function. Therefore, methods to investigate the structure of RNA in vivo are of great importance for understanding the role of cellular RNAs.
Kevin Xiao +2 more
doaj +4 more sources
Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides [PDF]
Trends in Pharmacological Sciences, 1989 Uridine and uracil nucleotides are involved in the regulation of various cell functions. Here, Roland Seifert and Günter Schultz review the evidence that, rather than by binding to purinoceptors, pyrimidine nucleotides exert their effects by binding to ...
G Schultz
exaly +6 more sources
Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes [PDF]
Journal of Cellular and Molecular Medicine, 2008 We previously showed that the human heart expresses all known P2X and P2Y receptors activated by extracellular adenine or uracil nucleotides. Despite evidence that, both in humans and rodents, plasma levels of ATP and UTP markedly increase during ...
Davide Lecca +2 more
exaly +5 more sources
Receptors responsive to extracellular uracil nucleotides [PDF]
Drug Development Research, 1998 The cloning of P2Y4 and P2Y3 (chicken)/P2Y6 (rat, human) receptors has been the ultimate proof that receptors for pyrimidine nucleotides exist. However, on the basis of their structure these receptors do not constitute a family of their own but belong to
Bernard Robaye +2 more
exaly +3 more sources
Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. [PDF]
J Pharmacol Exp Ther, 2013 The orphan receptor GPR17 has been reported to be activated by UDP, UDP-sugars, and cysteinyl leukotrienes, and coupled to intracellular Ca2+ mobilization and inhibition of cAMP accumulation, but other studies have reported either a different agonist ...
Qi AD, Harden TK, Nicholas RA.
europepmc +5 more sources
An uracil-linked hydroxyflavone probe for the recognition of ATP [PDF]
Beilstein Journal of Organic Chemistry, 2018 Background: Nucleotides are essential molecules in living systems due to their paramount importance in various physiological processes. In the past years, numerous attempts were made to selectively recognize and detect these analytes, especially ATP ...
Márton Bojtár +6 more
doaj +2 more sources
Biochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2013 Uracil phosphoribosyltransferase (UPRT) catalyzes the conversion of uracil and 5-phosphoribosyl-α-1-pyrophosphate (PRPP) to uridine 5'-monophosphate (UMP) and pyrophosphate (PP(i)). UPRT plays an important role in the pyrimidine salvage pathway since UMP
Anne Drumond Villela +8 more
doaj +3 more sources
Genetic analysis of pyrimidine biosynthetic enzymes in Plasmodium falciparum. [PDF]
PLoS PathogensThe malaria parasite Plasmodium falciparum depends entirely on de novo pyrimidine synthesis, as it is unable to salvage these essential nucleotides. This reliance makes the pyrimidine biosynthesis pathway a compelling target for antimalarial drugs, with ...
Krithika Rajaram +6 more
doaj +2 more sources
Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39 [PDF]
Frontiers in Microbiology, 2018 Pyrimidine nucleotides play an important role in the biosynthesis of activated nucleotide sugars (NDP-sugars). NDP-sugars are the precursors of structural polysaccharides in bacteria, including capsule, which is a major virulence factor of the human ...
Sandra M. Carvalho +8 more
doaj +2 more sources
Uracil nucleotides : from metabolic intermediates to neuroprotection and neuroinflammation
Biochemical Pharmacology, 2008 Uracil nucleotides (i.e., UTP and UDP) have been known for years as fundamental intermediates in the de novo synthesis of the other pyrimidine nucleotides, which altogether represent key building blocks for nucleic acid synthesis.
S. Ceruti, D. Lecca
core +4 more sources