Results 1 to 10 of about 14,080 (252)
Canadian Journal of Biochemistry and Physiology, 1957 Oxygen uptake could not be demonstrated when uracil, uridine, or uridylic acid and various supplements were incubated with rat liver preparations. Attention was directed towards the likelihood that the initial step of uracil catabolism in mammals is a reduction such as occurs in yeasts. Various techniques were employed to measure the possible reduction
J G, GOLDMAN, B, MCKAY, A H, SCHEIN
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Physical Chemistry Chemical Physics, 2007
We investigate the photochemistry and photodissociation dynamics of uracil by two-colour photofragment Doppler spectroscopy and by two-colour slice imaging at excitation wavelengths between 268 and 235 nm. We observe the loss of a hydrogen atom upon excitation into the pipi* state.
Michael, Schneider +4 more
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We investigate the photochemistry and photodissociation dynamics of uracil by two-colour photofragment Doppler spectroscopy and by two-colour slice imaging at excitation wavelengths between 268 and 235 nm. We observe the loss of a hydrogen atom upon excitation into the pipi* state.
Michael, Schneider +4 more
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Uracil Photoproducts from Uracil Irradiated in Ice
Science, 1969Two new products were isolated from uracil irradiated with ultraviolet light in frozen aqueous solution. As judged by mass, nuclear magnetic resonance, and ultraviolet and infrared spectra, one is a photopolymer, U 3 , and the structure of the other is probably 6-4′-[pyrimidin-2′-one]-uracil.
M N, Khattak, S Y, Wang
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Uracil-DNA Glycosylases and DNA Uracil Repair
1989Publisher Summary This chapter reviews the DNA uracil repair and uracil–DNA glycosylases (UDG). The major source of DNA uracil in prokaryotic and eukaryotic cells is transient incorporation of dUMP during replication. This replicative uracil is quickly repaired by UDG, apyramidinic/apurinic (AP) endonucleases, and other enzymes of excision repair ...
N V, Tomilin, O N, Aprelikova
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European Journal of Medicinal Chemistry, 2015
This review article is an effort to summarize recent developments in researches providing uracil derivatives with promising biological potential. This article also aims to discuss potential future directions on the development of more potent and specific uracil analogues for various biological targets. Uracils are considered as privileged structures in
Aleksandra, Pałasz, Dariusz, Cież
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This review article is an effort to summarize recent developments in researches providing uracil derivatives with promising biological potential. This article also aims to discuss potential future directions on the development of more potent and specific uracil analogues for various biological targets. Uracils are considered as privileged structures in
Aleksandra, Pałasz, Dariusz, Cież
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Drugs & Aging, 2001
Tegafur is a prodrug of the antineoplastic agent fluorouracil, and is administered in a 1:4 molar ratio with the fluorouracil modulator uracil. Oral tegafur/uracil 300 mg/m(2)/day plus calcium folinate 75 or 90 mg/day for 28 days every 35 days was as effective as intravenous (IV) fluorouracil 425 mg/m(2)/day plus folinic acid 20 mg/m(2)/day for 5 days ...
K, Wellington, K L, Goa
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Tegafur is a prodrug of the antineoplastic agent fluorouracil, and is administered in a 1:4 molar ratio with the fluorouracil modulator uracil. Oral tegafur/uracil 300 mg/m(2)/day plus calcium folinate 75 or 90 mg/day for 28 days every 35 days was as effective as intravenous (IV) fluorouracil 425 mg/m(2)/day plus folinic acid 20 mg/m(2)/day for 5 days ...
K, Wellington, K L, Goa
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The Photochemistry of Uracil: A Reinvestigation
Photochemistry and Photobiology, 2010AbstractResults from a re‐examination of the photochemical reactions undergone by uracil (Ura) are presented. Irradiation of Ura in frozen aqueous solution at −78.5°C produces two diastereomeric (6‐4) products, namely the cis and trans isomers of 5‐hydroxy‐6‐4′‐(pyrimidin‐2′‐one)‐5,6‐dihydrouracil.
Martin D, Shetlar, Vladimir J, Basus
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Science, 1962
Explorations in the pyrimidine series have led to the discovery of highly active herbicides, of which 3-butyl-6-methyluracil and 5-bromo-3-isopropyl-6-methyluracil are examples.
H C, BUCHA +4 more
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Explorations in the pyrimidine series have led to the discovery of highly active herbicides, of which 3-butyl-6-methyluracil and 5-bromo-3-isopropyl-6-methyluracil are examples.
H C, BUCHA +4 more
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The Synthesis of Uracils as Anticonvulsants*
Journal of the American Pharmaceutical Association (Scientific ed.), 1955Abstract A convenient laboratory synthesis has been devised by which a series of new 5‐alkyluracils has been prepared for evaluation as anti‐convulsants. Certain other 5‐substituted uracils and their N,N‐dimethyl derivatives, and related compounds, have also been synthesized.
J H, BURCKHALTER, H C, SCARBOROUGH
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PHOTOSENSITIZED DIMERIZATION OF URACIL
Photochemistry and Photobiology, 1972Abstract— The four isomeric dimers of uracil were isolated from photochemical reactions which were sensitized by acetone. Product analyses, made on the basis of the chemical properties of the compounds, showed that the h, h dimers predominate. Infrared and mass spectra for the dimers are here presented as well as nuclear magnetic resonance data.
B H, Jennings +2 more
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