Results 1 to 10 of about 1,466,903 (122)
Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N<sup>1</sup>-Methylpseudouridine Triphosphate. [PDF]
Angew Chem Int Ed EnglPseudouridine‐5′‐triphosphate (ΨTP) and its N1‐methylated derivative (m1ΨTP) are crucial components in mRNA vaccine technology. Here, an atom‐economic, high‐yielding biocatalytic route for ΨTP synthesis is presented. A new chemoenzymatic route for m1ΨTP synthesis was developed.
Pfeiffer M +4 more
europepmc +2 more sources
APOBEC3G protects the genome of human cultured cells and mice from radiation‐induced damage
The FEBS Journal, Volume 290, Issue 7, Page 1822-1839, April 2023., 2023 A3G protects mice from IR‐induced damage and promotes accurate DNA double‐strand breaks repair in cultured cells. Transgenic mice expressing A3G successfully survived lethal irradiation, whereas wild‐type controls quickly succumbed to radiation syndrome.
Yelena Britan‐Rosich +11 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 26, Issue 4, January 24, 2023., 2023 In this review, the potential of carbohydrates as starting materials for the synthesis of antimicrobial agents is explored. The most recent and successful reports of sugar‐based bactericides, bacteriostatic agents, and adhesin binders are covered with focus on the methodologies employed in their synthesis, resulting in a useful compilation of state‐of ...
Ana Marta de Matos
wiley +1 more source
The Verrucomicrobia LexA-binding Motif: Insights into the Evolutionary Dynamics of the SOS Response
Frontiers in Molecular Biosciences, 2016 The SOS response is the primary bacterial mechanism to address DNA damage, coordinating multiple cellular processes that include DNA repair, cell division and translesion synthesis.
Ivan Erill +3 more
doaj +1 more source
Novel molecules and target genes for vegetative heat tolerance in wheat
Plant-Environment Interactions, Volume 3, Issue 6, Page 264-289, December 2022., 2022 Chronic heat stress induces distinct physiological, metabolomic, and transcriptomic changes in a heat‐tolerant Triticum aestivum cultivar, Cadenza, compared to a susceptible cultivar, Paragon. Previously uncharacterized metabolites and genes are differentially regulated in the heat‐tolerant cultivar, providing potential for future crop heat tolerance ...
Teresa Rose +10 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, Volume 36, Issue 7, July 2022., 2022 Figure 1 Expression of OGG1 in HCC, (A) expression of OGG1 in nucleoplasma, (B, C) OGG1 expression in healthy liver tissues, (D, E, F) OGG1 expression in liver tissues of HCC patients (G) expression of OGG1 in HCC based on sample type (H) nodal metastasis status (I) TP53 mutation status (J) age (K) gender (L) race (M) stage (N) grade (O) histological ...
He Zhang +5 more
wiley +1 more source
Pharmacomicrobiomics: Influence of gut microbiota on drug and xenobiotic metabolism
The FASEB Journal, Volume 36, Issue 6, June 2022., 2022 Abstract Gut microbiota is the most diverse and complex biological ecosystem, which is estimated to consist of greater than 5 million distinct genes and 100 trillion cells which are in constant communication with the host environment. The interaction between the gut microbiota and drugs and other xenobiotic compounds is bidirectional, quite complicated,
Ifeoma Julieth Dikeocha +3 more
wiley +1 more source
The FEBS Journal, Volume 287, Issue 20, Page 4401-4414, October 2020., 2020 We performed alanine‐scanning mutagenesis of the extracellular loops of the yeast lysine transporter Lyp1. We find positions that affect either the localization or activity of Lyp1. Half of the affected mutants are located in the extension of extracellular loop 3 or in a predicted α‐helix in extracellular loop 4. We conclude that extracellular loops of
Joury S. van‘t Klooster +6 more
wiley +1 more source
CRISPR Assays for Protein Detection
Chemistry–Methods, Volume 6, Issue 3, March 2026.This review summarizes recent advances in CRISPR–Cas–based strategies for protein detection. Particular focus is placed on recognition element–based approaches, in which antibodies, aptamers, or DNAzymes convert protein binding into CRISPR‐readable nucleic acid signals, and activity‐based strategies that exploit intrinsic protein functions to trigger ...
Luca Capelli +5 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk +8 more
wiley +1 more source