Results 41 to 50 of about 2,150 (122)

Inducible and constitutive promoters for genetic systems in Sulfolobus acidocaldarius [PDF]

, 2018
Central to genetic work in any organism are the availability of a range of inducible and constitutive promoters. In this work we studied several promoters for use in the hyperthermophilic archaeon Sulfolobus acidocaldarius. The promoters were tested with
Albers, Sonja-Verena, Berkner, Silvia, Lipps, Georg, Wlodkowski, Alexander   +3 more
core  

Family-specific scaling laws in bacterial genomes [PDF]

, 2017
Among several quantitative invariants found in evolutionary genomics, one of the most striking is the scaling of the overall abundance of proteins, or protein domains, sharing a specific functional annotation across genomes of given size.
de Lazzari, Eleonora, Grilli, Jacopo, Lagomarsino, Marco Cosentino, Maslov, Sergei   +3 more
core   +3 more sources

RNA methylation‐related inhibitors: Biological basis and therapeutic potential for cancer therapy

Clinical and Translational Medicine, Volume 14, Issue 4, April 2024.
In this review, several common types of RNA modifications are reviewed, and the role of regulatory factors related to these modifications in cancer progression is discussed. Finally, the latest advances in small molecule inhibitors of these regulatory factors are especially reviewed. Abstract RNA methylation is widespread in nature. Abnormal expression
Huanxiang Chen, Hongyang Liu, Chenxing Zhang, Nan Xiao, Yang Li, Xiangzhuan Zhao, Ruike Zhang, Huihui Gu, Qiaozhen Kang, Junhu Wan   +9 more
wiley   +1 more source

Amygdala activation and GABAergic gene expression in hippocampal sub-regions at the interplay of stress and spatial learning [PDF]

, 2014
Molecular processes in GABAergic local circuit neurons critically contribute to information processing in the hippocampus and to stress-induced activation of the amygdala.
Anne Albrecht, Gal Richter-Levin, Oliver Stork, Osnat Hadad-Ophir   +3 more
core   +1 more source

Magic Permutation: QBEmax Achieves High‐Purity C‐to‐T Base Editing By Combining Cas9 Circular Permutation With Deaminase Domain Inlaying

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Min Li, Shaohua Yao
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +2 more sources

Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik [PDF]

, 2017
Defects of N-linked glycosylation represent diseases with multiple organ involvements that are classified as congenital disorders of glycosylation (CDG).
Aebi, Markus, Berger, Eric G., Frank, Christian G., Grubenmann, Claudia E., Hennet, Thierry, Hülsmeier, Andreas J., Matthijs, Gert, Mayatepek, Ertan, Schollen, Els   +8 more
core  

Small multicopy, non-integrative shuttle vectors based on the plasmid pRN1 for Sulfolobus acidocaldarius and Sulfolobus solfataricus, model organisms of the (cren-)archaea [PDF]

, 2007
The extreme thermoacidophiles of the genus Sulfolobus are among the best-studied archaea but have lacked small, reliable plasmid vectors, which have proven extremely useful for manipulating and analyzing genes in other microorganisms.
Albers, Sonja-Verena, Berkner, Silvia, Grogan, Dennis, Lipps, Georg   +3 more
core   +4 more sources

DNA repair, genome stability and cancer: a historical perspective [PDF]

, 2015
The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance.
A Karlsson, AC Minella, AL Murphree, AM Taylor, Antony M. Carr, AP Bird, AR Hartman, AR Lehmann, B Karahalil, B Lindell, B Mintz, B Vogelstein, BN Ames, CE Bronner, CH Spruck, CJ Lord, CJ Lord, CM Eischen, D Hanahan, D Pettijohn, DW Felsher, DW Schoppy, E Callen, E Farber, E Farber, EC Friedberg, EC Friedberg, EJ Fox, EJ Fox, EJ Hall, ER Fearon, F Laval, F Zindy, FS Leach, GL Moldovan, GM Cooper, GM Wahl, H Cavanagh, H Lee, HA Waldron, HJ Muller, HJ Muller, I Berenblum, I Martincorena, J Bartkova, J Cairns, J Laval, J Yamtich, JB Gurdon, JD Watson, JE Cleaver, JF Kerr, JM Bishop, K Illmensee, KW Kinzler, LA Loeb, LA Loeb, Laurence H. Pearl, LH Hartwell, LH Pearl, M Serrano, MB Kastan, MD Gray, MD Waterfield, MD Weitzman, ME Moynahan, MS Lindstrom, N Papadopoulos, NC Denko, O Vafa, P Bouwman, P Brookes, P Brookes, P Brookes, P Pott, PC Nowell, PE Polani, Penny A. Jeggo, PL Chen, R Fishel, RA Weinberg, RB Setlow, RE Franklin, RF Hill, RG McKinnell, S Ekholm-Reed, S Ljungquist, S Mai, SJ Baker, SJ Boulton, SK Sharan, SP Lees-Miller, T Boveri, T Lindahl, T Lindahl, TC Yang, TD Halazonetis, TF Deuel, VG Gorgoulis, WJ Burdette, Y Shiloh, Z Cui   +101 more
core   +1 more source

Targeting uracil-DNA glycosylases for therapeutic outcomes using insights from virus evolution [PDF]

, 2019
Ung-type uracil-DNA glycosylases are frontline defenders of DNA sequence fidelity in bacteria, plants, and animals; Ungs also directly assist both innate and humoral immunity.
Bouhamdan M, Chamberlin M, Friedberg EC, Katz GE, Le Rouzic E, Lindahl T, Lovett PS, Mahler I, Maisch WF, Price AR, Pyles RB, Renos Savva, Rhoades M, Stuart DT, Tomita F, Tomita F, Wang Z, Warner HR, Willetts KE   +18 more
core   +1 more source