Results 41 to 50 of about 1,466,903 (122)
, 2015 The most common mutations in cancer are C to T transitions, but their origin has remained elusive. Recently, mutational signatures of APOBEC-family cytosine deaminases were identified in many common cancers, suggesting off-target deamination of cytosine ...
Sousa, MML +9 more
core +1 more source
A unique uracil-DNA binding protein of the uracil DNA glycosylase superfamily
, 2015 Uracil DNA glycosylases (UDGs) are an important group of DNA repair enzymes, which pioneer the base excision repair pathway by recognizing and excising uracil from DNA.
Sang, Pau Biak +9 more
core +1 more source
Direct measurement of the substrate preference of uracil-DNA glycosylase. [PDF]
, 1998 Site-directed mutants of the herpes simplex virus type 1 uracil-DNA glycosylase lacking catalytic activity have been used to probe the substrate recognition of this highly conserved and ubiquitous class of DNA-repair enzyme utilizing surface plasmon ...
Barlow, T. +15 more
core +1 more source
Phage φ29 protein p56 prevents viral DNA replication impairment caused by uracil excision activity of uracil-DNA glycosylase [PDF]
, 2008 Protein p56 encoded by the Bacillus subtilis phage φ29 inhibits host uracil-DNA glycosylase (UDG) activity. In previous studies, we suggested that this inhibition is likely a defense mechanism developed by phage φ29 to prevent the action of UDG if ...
Bravo, Alicia +2 more
core +1 more source
A uracil-DNA glycosylase inhibitor encoded by a non-uracil containing viral DNA [PDF]
, 2006 Uracil-DNA glycosylase (UDG) is an enzyme involved in the base excision repair pathway. It specifically removes uracil from both single-stranded and double-stranded DNA. The genome of the Bacillus subtilis phage ϕ29 is a linear double-stranded DNA with a
Bravo, Alicia +2 more
core +1 more source
URACIL-DNA GLYCOSYLASES PREFERENTIALLY EXCISE MISPAIRED URACIL
, 1992 We have investigated the substrate specificity of human, viral and bacterial uracil-DNA glycosylases employing as substrate double-stranded oligonucleotides containing in the same position of the 5'-P-32-labelled strand an uracil residue facing, on the ...
MAZZARELLO P +3 more
core
UEG Week 2025 Oral Presentations
United European Gastroenterology Journal, Volume 13, Issue S8, Page S7-S188, October 2025.
wiley +1 more source
, 2006 Deamination of cytosine to uracil is a hydrolytic reaction that is greatly accelerated at high temperatures. The resulting uracil pairs with adenine during DNA replication, thereby inducing G:C to A:T transitions in the progeny.
Shimizu M +5 more
core +2 more sources
, 2016 Uracil DNA glycosylase (UNG) is an important DNA repair enzyme that recognizes and excises uracil bases in DNA using an extrahelical recognition mechanism.
Lauren Seiple (13505) +3 more
core +1 more source
, 1993 We have purified Herpes simplex type 1 (HSV1) uracil-DNA glycosylase from the nuclei of HSV1-infected HeLa cells harvested 8 h post-infection, at which time the induction of the enzyme is a maximum.
GAMBINO J +5 more
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