Results 31 to 40 of about 1,466,903 (122)
Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy
ChemPlusChem, Volume 90, Issue 7, July 2025.Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber +3 more
wiley +1 more source
Stimuli‐Responsive Silica Silanol Conjugates: Strategic Nanoarchitectonics in Targeted Drug Delivery
Small, Volume 20, Issue 39, September 26, 2024.The silica surface silanol chemistry and its conjugation to different cargos through stimuli‐responsive linkers are highly desired. This review elucidates silica's surface chemistry, types of silanols, silanol number and chemistry, chemical and physical identification, functionalization, and stimuli‐responsive for precise drug delivery systems ...
Shan Mohanan +4 more
wiley +1 more source
Inefficient excision of uracil from loop regions of DNA oligomers by E.coli uracil DNA glycosylase
, 1994 Kinetic parameters for uracil DNA glycosylase (E.coli)-catalysed excision of uracil from DNA oligomers containing dUMP in different structural contexts were determined.
N. Vinay Kumar +5 more
core +1 more source
RNA methylation‐related inhibitors: Biological basis and therapeutic potential for cancer therapy
Clinical and Translational Medicine, Volume 14, Issue 4, April 2024.In this review, several common types of RNA modifications are reviewed, and the role of regulatory factors related to these modifications in cancer progression is discussed. Finally, the latest advances in small molecule inhibitors of these regulatory factors are especially reviewed. Abstract RNA methylation is widespread in nature. Abnormal expression
Huanxiang Chen +9 more
wiley +1 more source
Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision
, 2019 Uracil DNA glycosylases (UDGs) are important DNA repair enzymes that excise uracil from DNA, yielding an abasic site. Recently, UdgX, an unconventional UDG with extremely tight binding to DNA containing uracil, was discovered.
Woo, Eui-Jeon +19 more
core +1 more source
Uracil recognition by archaeal family B DNA polymerases
Archaeal family-B DNA polymerases possess a novel uracil-sensing mechanism. A specialized pocket scans the template, ahead of the replication fork, for the presence of uracil; on encountering this base, DNA synthesis is stalled.
Wilson BT +3 more
core +5 more sources
MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Min Li, Shaohua Yao
wiley +1 more source
DNA excision repair of uracil and 5-fluorouracil in human cancercell lines [PDF]
, 2009 DNA er et tilsynelatende stabilt molekyl, som overføres så å si uten endringer fra unnfangelse til alderdom og fra generasjon til generasjon. Men arvestoffet vårt er ikke så uforanderlig som det kan se ut som.
Visnes, Torkild
core +1 more source
Replication Protein A (RPA) Targeting of Uracil DNA Glycosylase (UNG2) [PDF]
, 2021 Replication Protein A (RPA) is a single stranded DNA binding protein which stabilizes ssDNA for replication and repair. One function of RPA is to bind the DNA repair enzyme uracil DNA glycosylase (UNG2) and direct its activity towards ssDNA dsDNA ...
Weiser, Brian P, Chen, Derek
core +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +2 more sources