Results 31 to 40 of about 86,414 (313)

Viruses with U-DNA: New Avenues for Biotechnology

Viruses, 2021
Deoxyuridine in DNA has recently been in the focus of research due to its intriguing roles in several physiological and pathophysiological situations. Although not an orthodox DNA base, uracil may appear in DNA via either cytosine deamination or thymine ...
Kinga K. Nagy, Mikael Skurnik, Beáta G. Vértessy   +2 more
doaj   +1 more source

Comparative Study of the Gas-phase Cyclodimer Formations of Uracil and 6-azauracil in Excited State and Through Conical Intersections S0/S1

Acta Chimica Slovenica, 2018
The photocyclodimerization mechanisms of two oxo tautomers of uracil and 6-azauracil were studied at the CC2 level of theory and cc-pVDZ basis functions.
Pavlina Bogomilova Kancheva, Vassil Borissov Delchev   +1 more
doaj   +1 more source

Pyrimidine salvage in Toxoplasma gondii as a target for new treatment

Frontiers in Cellular and Infection Microbiology, 2023
Toxoplasmosis is a common protozoan infection that can have severe outcomes in the immunocompromised and during pregnancy, but treatment options are limited.
Hamza A. A. Elati, Hamza A. A. Elati, Amber L. Goerner, Bruno Martorelli Di Genova, Lilach Sheiner, Lilach Sheiner, Harry P. de Koning   +6 more
doaj   +1 more source

Probing the Molecular Frame of Uracil and Thymine with High Harmonic Generation Spectroscopy

, 2020
In this work we present computed high-harmonic generation (HHG) spectra of uracil and thyminemolecules, by means of the real-time time-dependent formulation of Gaussian-based configurationinteraction with single excitations (RT-TD-CIS).
Emanuele, Coccia, Eleonora, Luppi
core   +1 more source

Detection of Genomic Uracil Patterns

, 2021
The appearance of uracil in the deoxyuridine moiety of DNA is among the most frequently occurring genomic modifications. Three different routes can result in genomic uracil, two of which do not require specific enzymes: spontaneous cytosine deamination ...
Hajnalka Laura Pálinkás, Angéla Békési, Eszter Holub, Beáta G. Vértessy   +3 more
core   +1 more source

Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules

Molecules, 2019
Iodonium(III) salts bearing uracil moieties have recently appeared in the literature, but their structural scope and utilization are limited because of their hygroscopic characteristics.
Naoko Takenaga, Takumi Hayashi, Shohei Ueda, Hiroyuki Satake, Yoichi Yamada, Tetsuya Kodama, and Toshifumi Dohi   +6 more
doaj   +1 more source

Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening

Biochemistry and Biophysics Reports, 2021
Uracil DNA glycosylases are an important class of enzymes that hydrolyze the N-glycosidic bond between the uracil base and the deoxyribose sugar to initiate uracil excision repair.
Avani Mehta, Prateek Raj, Sandeep Sundriyal, Balasubramanian Gopal, Umesh Varshney   +4 more
doaj   +1 more source

A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine

, 2014
We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzyme’s active ...
Fox, Keith R., Kimber, Scott T., Keith R. Fox, Brown, T, Fox, KR, Tom Brown, Brown, Tom, Brown, Thomas, Kimber, ST, Scott T. Kimber, Scott T Kimber, Keith R Fox   +11 more
core   +1 more source

Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification

Frontiers in Immunology, 2021
Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosylase ...
Marina Alexeeva, Marivi Nabong Moen, Marivi Nabong Moen, Xiang Ming Xu, Anette Rasmussen, Ingar Leiros, Finn Kirpekar, Arne Klungland, Lene Alsøe, Lene Alsøe, Hilde Nilsen, Hilde Nilsen, Svein Bjelland, Svein Bjelland   +13 more
doaj   +1 more source

5,5-Dichloro-6-hydroxydihydropyrimidine-2,4(1H,3H)-dione: molecular and crystal structure, Hirshfeld surface analysis and the new route for synthesis with Mg(ReO4)2 as a new catalyst

Acta Crystallographica Section E: Crystallographic Communications, 2020
The molecular and crystal structures of the title compound, C4H4Cl2N2O3, were investigated by single-crystal X-ray diffraction and a Hirshfeld surface analysis.
Anton P. Novikov, Sergey N. Ryagin, Mikhail S. Grigoriev, Alexey V. Safonov, Konstantin E. German   +4 more
doaj   +1 more source