Results 21 to 30 of about 76,412 (252)

Synthesis, Herbicidal Activity, Mode of Action, and In Silico Analysis of Novel Pyrido[2,3-d]pyrimidine Compounds

Molecules, 2023
Natural products are a main source of new chemical entities for use in drug and pesticide discovery. In order to discover lead compounds with high herbicidal activity, a series of new pyrido[2,3-d] pyrimidine derivatives were designed and synthesized ...
Lijing Min, Wei Liang, Joanna Bajsa-Hirschel, Peng Ye, Qiao Wang, Xinpeng Sun, Charles L. Cantrell, Liang Han, Nabo Sun, Stephen O. Duke, Xinghai Liu   +10 more
doaj   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Quantum-сhemical analysis of geometric and energetic characteristics of hetero associates m9Ade•m1Ura in main tautomeric form

Біологічні студії, 2015
For the first time, on the quantum-mechanical level of theory MP2/6-311++G(2df,pd)//B3LYP/6-311++G(d,p), a full set of hydrogen (H)-bonded hetero associates m9Ade·m1Ura in the main tautomeric forms consisting of 18 different structures was obtained ...
D. Plodnik, I. Voiteshenko, D. Hovorun
doaj   +1 more source

Viruses with U-DNA: New Avenues for Biotechnology

Viruses, 2021
Deoxyuridine in DNA has recently been in the focus of research due to its intriguing roles in several physiological and pathophysiological situations. Although not an orthodox DNA base, uracil may appear in DNA via either cytosine deamination or thymine ...
Kinga K. Nagy, Mikael Skurnik, Beáta G. Vértessy   +2 more
doaj   +1 more source

Pyrimidine salvage in Toxoplasma gondii as a target for new treatment

Frontiers in Cellular and Infection Microbiology, 2023
Toxoplasmosis is a common protozoan infection that can have severe outcomes in the immunocompromised and during pregnancy, but treatment options are limited.
Hamza A. A. Elati, Hamza A. A. Elati, Amber L. Goerner, Bruno Martorelli Di Genova, Lilach Sheiner, Lilach Sheiner, Harry P. de Koning   +6 more
doaj   +1 more source

Uracil mustard revisited [PDF]

Cancer, 1999
A patient with diffuse large cell lymphoma who had a complete response lasting 35 years following a 3-day course of uracil mustard stimulated a recall review of patients treated with this oral alkylating agent.Records of patients treated with uracil mustard between 1958 and 1970 were reviewed.
B J, Kennedy, J L, Torkelson, E, Torlakovic   +2 more
openaire   +2 more sources

Comparative Study of the Gas-phase Cyclodimer Formations of Uracil and 6-azauracil in Excited State and Through Conical Intersections S0/S1

Acta Chimica Slovenica, 2018
The photocyclodimerization mechanisms of two oxo tautomers of uracil and 6-azauracil were studied at the CC2 level of theory and cc-pVDZ basis functions.
Pavlina Bogomilova Kancheva, Vassil Borissov Delchev   +1 more
doaj   +1 more source

Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules

Molecules, 2019
Iodonium(III) salts bearing uracil moieties have recently appeared in the literature, but their structural scope and utilization are limited because of their hygroscopic characteristics.
Naoko Takenaga, Takumi Hayashi, Shohei Ueda, Hiroyuki Satake, Yoichi Yamada, Tetsuya Kodama, and Toshifumi Dohi   +6 more
doaj   +1 more source

Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening

Biochemistry and Biophysics Reports, 2021
Uracil DNA glycosylases are an important class of enzymes that hydrolyze the N-glycosidic bond between the uracil base and the deoxyribose sugar to initiate uracil excision repair.
Avani Mehta, Prateek Raj, Sandeep Sundriyal, Balasubramanian Gopal, Umesh Varshney   +4 more
doaj   +1 more source

Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification

Frontiers in Immunology, 2021
Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosylase ...
Marina Alexeeva, Marivi Nabong Moen, Marivi Nabong Moen, Xiang Ming Xu, Anette Rasmussen, Ingar Leiros, Finn Kirpekar, Arne Klungland, Lene Alsøe, Lene Alsøe, Hilde Nilsen, Hilde Nilsen, Svein Bjelland, Svein Bjelland   +13 more
doaj   +1 more source