Results 41 to 50 of about 26,862 (228)

Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice

Virology Journal, 2008
Background Low levels of uracil in DNA result from misincorporation of dUMP or cytosine deamination. Vaccinia virus (VACV), the prototype poxvirus, encodes two enzymes that can potentially reduce the amount of uracil in DNA.
Moss Bernard, De Silva Frank S
doaj   +1 more source

Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings

Frontiers in Plant Science, 2023
In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination.
Robert D. Slocum, Carolina Mejia Peña, Zhongchi Liu   +2 more
doaj   +1 more source

Molecular characterization of the virulent infectious hematopoietic necrosis virus (IHNV) strain 220-90

Virology Journal, 2010
Background Infectious hematopoietic necrosis virus (IHNV) is the type species of the genus Novirhabdovirus, within the family Rhabdoviridae, infecting several species of wild and hatchery reared salmonids.
LaPatra Scott E, Ammayappan Arun, Vakharia Vikram N   +2 more
doaj   +1 more source

Metabolome analysis of genus Forsythia related constituents in Forsythia suspensa leaves and fruits using UPLC-ESI-QQQ-MS/MS technique.

PLoS ONE, 2022
Forsythia suspensa is a traditional Chinese herb. Its numerous metabolites have important roles, as they possessed a wide range of biological activities. This study explored the accumulations of F.
Lingdi Liu, Yu Sun, Chunxiu Wen, Tao Jiang, Wei Tian, Xiaoliang Xie, Xusheng Cui, Ruike Lu, Jiaxing Feng, Aihong Jin, Saiqun Wen, Wei Wei   +11 more
doaj   +1 more source

Characterization by Small RNA Sequencing of Taro Bacilliform CH Virus (TaBCHV), a Novel Badnavirus. [PDF]

PLoS ONE, 2015
RNA silencing is an antiviral immunity that regulates gene expression through the production of small RNAs (sRNAs). In this study, deep sequencing of small RNAs was used to identify viruses infecting two taro plants.
Syeda Amber Kazmi, Zuokun Yang, Ni Hong, Guoping Wang, Yanfen Wang   +4 more
doaj   +1 more source

Protected 5-(hydroxymethyl)uracil nucleotides bearing visible-light photocleavable groups as building blocks for polymerase synthesis of photocaged DNA

, 2018
Protected 5-(hydroxymethyl)uracil nucleotides bearing photocleavable groups as building blocks for polymerase synthesis of photocaged DNA.
Petr Klán, Lucie Ludvíková, Lenka Poštová Slavětínská, Michal Hocek, Zuzana Vaníková, Soňa Boháčová   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs. [PDF]

PLoS ONE, 2011
Dwarfism in German shepherd dogs is due to combined pituitary hormone deficiency of unknown genetic cause. We localized the recessively inherited defect by a genome wide approach to a region on chromosome 9 with a lod score of 9.8.
Annemarie M W Y Voorbij, Frank G van Steenbeek, Manon Vos-Loohuis, Ellen E C P Martens, Jeanette M Hanson-Nilsson, Bernard A van Oost, Hans S Kooistra, Peter A Leegwater   +7 more
doaj   +1 more source

Structural analysis of leucine, lysine and tryptophan mitochondrial tRNA of nesting turtles Caretta caretta (Testudines: Chelonioidea) in the Colombian Caribbean [PDF]

PeerJ, 2020
The understanding of the functional properties of mitochondrial transfer RNA (mt tRNAs) depend on the knowledge of its structure. tRNA acts as an interface between polynucleotides and polypeptides thus, they are key molecules in protein biosynthesis. The
Harvey Infante-Rojas, Leonardo Marino-Ramirez, Javier Hernández-Fernández   +2 more
doaj   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source