Results 41 to 50 of about 107,812 (233)

Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]

, 2000
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner, Faussner, Alexander, Adelbert A. Roscher, Roscher, Adelbert A.   +3 more
core   +1 more source

Interactions of Some Divalent Metal Ions with Thymine and Uracil Thiosemicarbazide Derivatives [PDF]

, 2016
The study of interactions between metal ions and nucleobases, nucleosides, nucleotides, or nucleic acids has become an active research area in chemical, biological, and therapeutic fields.
El-Dakdouki, Mohammad H., Bouhadir, Kamal Hani, Hammud, Hassan Hasan, Sonji, Ghassan M., Sonji, Nada M.   +4 more
core   +1 more source

Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice

Virology Journal, 2008
Background Low levels of uracil in DNA result from misincorporation of dUMP or cytosine deamination. Vaccinia virus (VACV), the prototype poxvirus, encodes two enzymes that can potentially reduce the amount of uracil in DNA.
Moss Bernard, De Silva Frank S
doaj   +1 more source

Molecular characterization of the virulent infectious hematopoietic necrosis virus (IHNV) strain 220-90

Virology Journal, 2010
Background Infectious hematopoietic necrosis virus (IHNV) is the type species of the genus Novirhabdovirus, within the family Rhabdoviridae, infecting several species of wild and hatchery reared salmonids.
LaPatra Scott E, Ammayappan Arun, Vakharia Vikram N   +2 more
doaj   +1 more source

Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings

Frontiers in Plant Science, 2023
In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination.
Robert D. Slocum, Carolina Mejia Peña, Zhongchi Liu   +2 more
doaj   +1 more source

Dynamic Operations in Macromolecular Data Storage

Angewandte Chemie, EarlyView.
With the exponential growth of digital data and the limitations of conventional silicon‐based storage and computing technologies, macromolecular data storage, the practice of encoding digital information within large, complex molecules like DNA or synthetic polymers, has emerged as a scalable and sustainable alternative to traditional digital ...
Jakub Ossowski, Oskar Affenberger, Jean‐François Lutz, Maria Nerantzaki   +3 more
wiley   +2 more sources

Metabolome analysis of genus Forsythia related constituents in Forsythia suspensa leaves and fruits using UPLC-ESI-QQQ-MS/MS technique.

PLoS ONE, 2022
Forsythia suspensa is a traditional Chinese herb. Its numerous metabolites have important roles, as they possessed a wide range of biological activities. This study explored the accumulations of F.
Lingdi Liu, Yu Sun, Chunxiu Wen, Tao Jiang, Wei Tian, Xiaoliang Xie, Xusheng Cui, Ruike Lu, Jiaxing Feng, Aihong Jin, Saiqun Wen, Wei Wei   +11 more
doaj   +1 more source

Biotin‐ and Chloroalkane‐Modified Nucleotides for Dual Display of Proteins on DNA Through Streptavidin and Halotag Binding

Angewandte Chemie, EarlyView.
Modified 2’‐deoxy‐7‐deazaadenosine bearing a chlorohexyl moiety and 2’‐deoxycytidine nucleotides bearing biotin were used in the enzymatic synthesis of dually modified dsDNAs that served as scaffolds for display of halotag and monomeric streptavidin proteins.
Giammarco Liuni, Lenka Poštová Slavětínská, Miroslav Hájek, Veronika Raindlová, Michal Hocek   +4 more
wiley   +2 more sources

Characterization by Small RNA Sequencing of Taro Bacilliform CH Virus (TaBCHV), a Novel Badnavirus. [PDF]

PLoS ONE, 2015
RNA silencing is an antiviral immunity that regulates gene expression through the production of small RNAs (sRNAs). In this study, deep sequencing of small RNAs was used to identify viruses infecting two taro plants.
Syeda Amber Kazmi, Zuokun Yang, Ni Hong, Guoping Wang, Yanfen Wang   +4 more
doaj   +1 more source

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

eLife, 2013
Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions, often associated with ...
Benjamin JM Taylor, Serena Nik-Zainal, Yee Ling Wu, Lucy A Stebbings, Keiran Raine, Peter J Campbell, Cristina Rada, Michael R Stratton, Michael S Neuberger   +8 more
doaj   +1 more source