Results 31 to 40 of about 26,862 (228)
Structure Characterization of Escherichia coli Pseudouridine Kinase PsuK
Frontiers in Microbiology, 2022 Pseudouridine (Ψ) is one of the most abundant RNA modifications in cellular RNAs that post-transcriptionally impact many aspects of RNA. However, the metabolic fate of modified RNA nucleotides has long been a question. A pseudouridine kinase (PsuK) and a
Xiaojia Li +7 more
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Nature Communications, 2023 Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive.
Chia-Shin Yang +5 more
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The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes [PDF]
Molecular Pharmacology, 2017 Pairing orphan G protein–coupled receptors (GPCRs) with their cognate endogenous ligands is expected to have a major impact on our understanding of GPCR biology. It follows that the reproducibility of orphan receptor ligand pairs should be of fundamental importance to guide meaningful investigations into the pharmacology and function of individual ...
Katharina, Simon +12 more
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The epitranscriptome in stem cell biology and neural development
Neurobiology of Disease, 2020 The blossoming field of epitranscriptomics has recently garnered attention across many fields by findings that chemical modifications on RNA have immense biological consequences.
Caroline Vissers +3 more
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Expression of microRNAs in Horse Plasma and Their Characteristic Nucleotide Composition. [PDF]
PLoS ONE, 2016 MicroRNAs (miRNAs) in blood plasma are stable under high levels of ribonuclease activity and could function in tissue-to-tissue communication, suggesting that they may have distinctive structural characteristics compared with non-circulating miRNAs.
Seungwoo Lee +7 more
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Molecular Therapy: Nucleic Acids, 2022 Precise genome editing of human pluripotent stem cells (hPSCs) is crucial not only for basic science but also for biomedical applications such as ex vivo stem cell therapy and genetic disease modeling.
Ju-Chan Park +7 more
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G3: Genes, Genomes, Genetics, 2020 Analysis of synonymous mutations established that although the primary amino acid sequence remains unchanged, alterations in transcription and translation can result in significant phenotypic consequences. We report the novel observation that a series of
Hadiar Rahman +8 more
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, 2023 Short-wave ultraviolet (also called UVC) irradiation is a well-adopted method of viral inactivation due to its ability to damage genetic material. A fundamental problem with the UVC inactivation method is that its mechanism of action on viruses is still ...
Wang, S. +15 more
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Northern Blot of tRNA in Yeast
Bio-Protocol, 2013 tRNAs are small RNAs around 70-90 nt. tRNAs are different from many other small RNAs in that they are very abundant, which makes it difficult to study their transcriptional regulation by traditional northern blot.
Yuehua Wei
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A novel and specific fluorescence reaction for uracil. [PDF]
, 2010 Facile and specific methods to quantify a nucleobase in biological samples are of great importance for diagnosing disorders in nucleic acid metabolism. In the present study, a novel fluorogenic reaction specific for uracil has been developed.
Tsutomu Kabashima +9 more
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