Results 51 to 60 of about 26,862 (228)

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

eLife, 2013
Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions, often associated with ...
Benjamin JM Taylor, Serena Nik-Zainal, Yee Ling Wu, Lucy A Stebbings, Keiran Raine, Peter J Campbell, Cristina Rada, Michael R Stratton, Michael S Neuberger   +8 more
doaj   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Reversed-phase liquid chromatography of 5-fluoro-uracil nucleosides and nucleotides in the presence of quaternary ammonium ions

, 1980
Reversed-phase liquid chromatography is used for the separation of 5-fluoro-uracil, its deoxyribo- and ribonucleosides and nucleotides. The bases and nucleosides are easily separated from their naturally occurring analogues on an octadecyl silica column ...
A.P. De Leenheer, C.F. Gelijkens, Gelijkens, CF, De Leenheer, Andreas   +3 more
core   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Bacteriophage-related epigenetic natural and non-natural pyrimidine nucleotides and their influence on transcription with T7 RNA polymerase

Communications Chemistry
DNA modifications on pyrimidine nucleobases play diverse roles in biology such as protection of bacteriophage DNA from enzymatic cleavage, however, their role in the regulation of transcription is underexplored.
Filip Gracias, Radek Pohl, Veronika Sýkorová, Michal Hocek   +3 more
doaj   +1 more source

The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor.

, 2006
Nucleotides and cysteinyl-leukotrienes (CysLTs) are unrelated signaling molecules inducing multiple effects through separate G-protein-coupled receptors: the P2Y and the CysLT receptors.
ABBRACCHIO MP, MARTINI, CLAUDIA, L. Sironi, Silvia Belcredito, U. Guerrini, Claudia Verderio, C. Parravicini, LECCA D, Marta Fumagalli, GUERRINI U., Valérie Capra, ROVATI G. E., PARRAVICINI C, M.P. Abbracchio, P. Gelosa, E. Tremoli, VERDERIO C, CIMINO M., S. Belcredito, SIRONI L, Silvia Ferrario, CIMINO, MAURO, GELOSA P., ROVATI GE, FERRARIO S., BELCREDITO S., Chiara Parravicini, CIANA P, C. Martini, M. Fumagalli, P. Rosa, Maria P Abbracchio, Paolo Gelosa, D. Lecca, CAPRA V., M. Cimino, Elena Tremoli, ABBRACCHIO M. P., C. Verderio, VERDERIO C., LECCA D., G Enrico Rovati, G. Rovati, TREMOLI E, MARTINI C, SIRONI L., ROSA P, FUMAGALLI M., TREMOLI E., Uliano Guerrini, CIANA P., V.C. Capra, FUMAGALLI M, Mauro Cimino, GUERRINI U, TRINCAVELLI, MARIA LETIZIA, Luigi Sironi, Patrizia Rosa, TRINCAVELLI ML, Paolo Ciana, BELCREDITO S, Maria Letizia Trincavelli, CAPRA V, GELOSA P, ROSA P., S. Ferrario, Claudia Martini, PARRAVICINI C., P. Ciana, M. L. Trincavelli, FERRARIO S, Davide Lecca   +71 more
core   +1 more source

A Modular Nucleoside Kinase Cascade for the Synthesis of Ribonucleoside Triphosphates

Biotechnology and Bioengineering, EarlyView.
Damm et al. report standardized enzymatic cascades for production of all canonical nucleoside triphosphates from the corresponding nucleosides, using kinase‐catalyzed phosphorylation from acetyl phosphate. Reactions afforded ∼ 100 mM product in near‐quantitative conversion.
Oliver T. Damm, Martin Pfeiffer, Johannes Zöhrer, Bernd Nidetzky   +3 more
wiley   +1 more source

UDP-glucose and MRS2905 agonist-bound states of the purinergic P2Y14 receptor

Communications Biology
P2Y14 receptors respond to uracil-diphosphate-hexose conjugates, yet how this receptor selectively recognizes both uracil-nucleotides and hexose moieties of diverse agonists remains unclear.
Jonathan F. Fay, Joseph Kousouros, Zhan-Guo Gao, Matteo Pavan, Paola Oliva, Asmita Pramanik, Clayton Meyer, Siva Hariprasad Kurma, Wen Xu, Brian Krumm, Kenneth A. Jacobson   +10 more
doaj   +1 more source

The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. [PDF]

PLoS ONE, 2008
Deciphering the mechanisms regulating the generation of new neurons and new oligodendrocytes, the myelinating cells of the central nervous system, is of paramount importance to address new strategies to replace endogenous damaged cells in the adult brain
Davide Lecca, Maria Letizia Trincavelli, Paolo Gelosa, Luigi Sironi, Paolo Ciana, Marta Fumagalli, Giovanni Villa, Claudia Verderio, Carlotta Grumelli, Uliano Guerrini, Elena Tremoli, Patrizia Rosa, Serena Cuboni, Claudia Martini, Annalisa Buffo, Mauro Cimino, Maria P Abbracchio   +16 more
doaj   +1 more source

Identification of novel genes regulating the development of the palate

Developmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source