Results 71 to 80 of about 107,812 (233)

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

Synthesis and investigation of modified uracil and cytosine nucleosides and nucleotides. [PDF]

, 2016
Synthesis and Investigation of Modified Uracil and Cytosine Nucleosides and ...
Dabužinskaitė, Julija,
core  

Double‐Headed Nucleotides with Increased Base‐Pairing Affinity and Specificity [PDF]

, 2021
Double-headed nucleotides, i. e., nucleotides that hold two nucleobases each, have been shown to be double-functional in DNA duplexes by forming two sets of Watson−Crick base pairs, and thus mimicking dinucleotides.
Beck, Kasper Munch, Robert L. Pham, Poul Nielsen, Laustsen, Anders, Nielsen, Poul; id_orcid, L. Pham, Robert, Kasper M. Beck, Rita A. Nanim, Anders Laustsen, A. Nanim, Rita   +9 more
core   +1 more source

The relationship between gene traits and transcription in soil microbial communities varies by environmental stimulus [PDF]

PeerJ
Codon and nucleotide frequencies are known to relate to the rate of gene transcription, yet how these traits shape transcriptional profiles of soil microbial communities remains unclear.
Peter F. Chuckran, Steven J. Blazewicz, Javier A. Ceja-Navarro, Jennifer Pett-Ridge, Egbert Schwartz, Paul Dijkstra   +5 more
doaj   +2 more sources

Synthesis and molecular modeling of novel HSV1 uracil-DNA glycosylase inhibitors.

, 1999
In a recent paper the first selective inhibitors of HSV1 uracil-DNA glycosylase (UDG) acting in the micromolar range have been reported. A 28.5 kDa catalytic fragment of HSV1 UDG has been crystallized in the presence of uracil, and the structure was ...
Verri A, Pregnolato M, Ubiali D, Spadari S, Zhi C, Sun H, Wright GE, Focher F   +7 more
core   +2 more sources

Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Hydrolytic deamination of cytosine to uracil generates a highly mutagenic DNA base lesion and is considered one of the major sources of spontaneous mutation in living organisms. We report that the major human apurinic/apyrimidinic (AP) endonuclease, APE1, is a deoxyuridine endonuclease and can remove uracil residues in ...
Prorok, P., Alili, D., Saint-Pierre, C., Gasparutto, D., Zharkov, D., Ishchenko, A., Tudek, B., Saparbaev, M.   +7 more
openaire   +3 more sources

Reversed-phase liquid chromatography of 5-fluoro-uracil nucleosides and nucleotides in the presence of quaternary ammonium ions

, 1980
Reversed-phase liquid chromatography is used for the separation of 5-fluoro-uracil, its deoxyribo- and ribonucleosides and nucleotides. The bases and nucleosides are easily separated from their naturally occurring analogues on an octadecyl silica column ...
A.P. De Leenheer, C.F. Gelijkens, Gelijkens, CF, De Leenheer, Andreas   +3 more
core   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Analysis of Z64 genetic code network [PDF]

Network Biology
The genetic code is the set of rules defining how the sequence of nucleotides in DNA or RNA determines the specific amino acid sequence in the synthesis of protein.
Adil Akhtar, Nasrin Irshad Hussain
doaj  

Understanding the interaction of nucleotides with UVC light: an insight from quantum chemical calculation-based findings

, 2023
Short-wave ultraviolet (also called UVC) irradiation is a well-adopted method of viral inactivation due to its ability to damage genetic material. A fundamental problem with the UVC inactivation method is that its mechanism of action on viruses is still ...
Wang, S., Ye, H., Li, Shizhen (author), Huang, Qianming, Liu, X., Huang, Qianming (author), Ye, H. (author), Wang, S. (author), Zhang, Kouchi, Li, Shizhen, Tan, C. (author), Zhang, Kouchi (author), Liu, X. (author), Tan, C., Yang, Huiru (author), Yang, Huiru   +15 more
core   +2 more sources