Results 71 to 80 of about 26,862 (228)

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Genetic Tools in the Nakaseomyces clade for Evolutionary Comparisons of Signal Transduction Pathways

Yeast, EarlyView.
ABSTRACT The genus Nakaseomyces provides four species that are closely related but have different characteristics. For example, N. glabratus (formerly known as Candida glabrata) is a common human pathogen, whereas N. bracarensis and N. nivariensis have been isolated in clinical settings but are not common human pathogens. N.
Maria Abraham, Christine L. Iosue, Dennis D. Wykoff   +2 more
wiley   +1 more source

Ribosylurea accumulates in yeast urc4 mutants.

, 2010
Yeast Saccharomyces (Lachancea) kluyveri urc4 mutants, unable to grow on uracil, biotransformed (14)C(2)-uracil into two labeled compounds, as detected by high performance liquid chromatography (HPLC). These two compounds could also be obtained following
G. Andersen, Domkin, Vladimir,, Rasmussen, Anna, V. Domkin, Björnberg, O, Vodnala, Munender,, A. Hofer, M. Vodnala, Andersen, G, J. Piškur, Piskur, J, A. Rasmussen, Piskur, Jure, Hofer, Anders,, Björnberg, Olof, Vodnala, M, O. Björnberg, Hofer, A, Domkin, V, Rasmussen, A   +19 more
core   +1 more source

Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum. [PDF]

, 2011
We investigated the possible modulation of the intestinal contractility by uracil nucleotides (UTP and UDP), using as model the murine small intestine.
Jasmin Grählert, Grählert J, Rosa Serio, Mariangela Mastropaolo, Maria Grazia Zizzo, Flavia Mulè, ZIZZO, Maria Grazia, MULE', Flavia, MASTROPAOLO, Mariangela, SERIO, Rosa Maria   +9 more
core   +1 more source

Responses of the longitudinal muscle and the muscularis mucosae of the rat duodenum to adenine and uracil nucleotides [PDF]

British Journal of Pharmacology, 1996
Previous studies have shown that the rat duodenum contains P1 and P2Y purinoceptors via which it relaxes to adenosine and adenosine 5′‐triphosphate (ATP) respectively. It has also been shown to contract to uridine 5′‐triphosphate (UTP) and adenosine 5′‐O‐(3‐thiotriphosphate) (ATP‐γ‐S), and based on their differential inhibition by the P2 antagonist ...
C R, Johnson, S J, Charlton, S M, Hourani   +2 more
openaire   +2 more sources

Novel Variants in PUS7 Associated With Intellectual Disability and Growth Retardation: Expanding the Clinical Spectrum in 13 Patients

Clinical Genetics, EarlyView.
Novel variants in PUS7 associated with intellectual disability and growth retardation: expanding the clinical spectrum in 13 patients. ABSTRACT Pseudouridylation is a frequent post‐transcriptional modification resulting in uridine isomerization in 5‐ribosyluracil, also called pseudouridine. This mechanism leads to RNA stability with an increase in base‐
Camille Bergès, Clément Sauvestre, Sophie Naudion, Catherine Vincent Delorme, Thomas Smol, Mélanie Rama, Stephanie Moortgat, Isabelle Maystadt, Rogier Kersseboom, Martina Wilke, Stefan Barakat, Yoann Vial, Laurence Perrin, Sandrine Passemard, Farooq Ahmad, Muhammad Umair, Tobias Haack, Mona Grimmel, Alma Kuechler, Anne Slavotinek, Patrick Devine, Ugur Hodoglugil, Faisal Zafar, Erum Afzal, Tracy Dudding‐Byth, Guillaume Jouret, Lucas Herissant, Stephanie Efthymiou, Henry Houlden, Marine Legendre, Vincent Michaud   +30 more
wiley   +1 more source

Complete genome sequence of Mycoplasma suis and insights into its biology and adaption to an erythrocyte niche. [PDF]

PLoS ONE, 2011
Mycoplasma suis, the causative agent of porcine infectious anemia, has never been cultured in vitro and mechanisms by which it causes disease are poorly understood. Thus, the objective herein was to use whole genome sequencing and analysis of M.
Ana M S Guimaraes, Andrea P Santos, Phillip SanMiguel, Thomas Walter, Jorge Timenetsky, Joanne B Messick   +5 more
doaj   +1 more source

Homologous recombination mutants cause differing lethality between h− and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin

The FEBS Journal, EarlyView.
Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar, Siarhei Paliavoi, Barbora Stefanovie, Jan Josef Palecek   +3 more
wiley   +1 more source

Analysis of Z64 genetic code network [PDF]

Network Biology
The genetic code is the set of rules defining how the sequence of nucleotides in DNA or RNA determines the specific amino acid sequence in the synthesis of protein.
Adil Akhtar, Nasrin Irshad Hussain
doaj  

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source