Results 61 to 70 of about 26,862 (228)
Metabolites, 2019 We used nuclear magnetic spectroscopy (NMR) to evaluate the metabolic impacts of crude oil, Corexit 5900A, a dispersant, and a crude oil Corexit 5900A mixture exposure on skeletal muscle, heart, and liver physiology of hatchling loggerhead sea turtles ...
Stasia A. Bembenek-Bailey +6 more
doaj +1 more source
Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis
BMC Research Notes, 2019 Objective Planarians including Dugesia ryukyuensis (Dr) have strong regenerative abilities that require enhanced DNA replication. Knockdown of the DUT gene in Dr, which encodes deoxyuridine 5′-triphosphate pyrophosphatase (dUTPase), promotes DNA ...
Md. Shahanoor Alam +2 more
doaj +1 more source
Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy +7 more
wiley +1 more source
Synthesis and molecular modeling of novel HSV1 uracil-DNA glycosylase inhibitors
, 1999 In a recent paper the first selective inhibitors of HSV1 uracil-DNA glycosylase (UDG) acting in the micromolar range have been reported. A 28.5 kDa catalytic fragment of HSV1 UDG has been crystallized in the presence of uracil, and the structure was ...
UBIALI, DANIELA +7 more
core +1 more source
Journal of Raman Spectroscopy, EarlyView.Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira +3 more
wiley +1 more source
The relationship between gene traits and transcription in soil microbial communities varies by environmental stimulus [PDF]
PeerJCodon and nucleotide frequencies are known to relate to the rate of gene transcription, yet how these traits shape transcriptional profiles of soil microbial communities remains unclear.
Peter F. Chuckran +5 more
doaj +2 more sources
A Determination of the Sequence-Dependent Kinetic Constants of Uracil-DNA Glycosylase
, 2021 : Mutations in the DNA of somatic cells, resulting from inaccuracies in DNA replication or exposure to harsh conditions (ionizing radiation, carcinogens), may be loss-of-function mutations, and the compounding of these mutations can lead to cancer.
core
Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Hydrolytic deamination of cytosine to uracil generates a highly mutagenic DNA base lesion and is considered one of the major sources of spontaneous mutation in living organisms. We report that the major human apurinic/apyrimidinic (AP) endonuclease, APE1, is a deoxyuridine endonuclease and can remove uracil residues in the DNA ...
Prorok, P. +7 more
openaire +3 more sources
Pest Management Science, EarlyView.RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden +3 more
wiley +1 more source
The etiology of uracil residues in the Saccharomyces cerevisiae genomic DNA
, 2018 Non-canonical residue in DNA is a major and conserved source of genome instability. The appearance of uracil residues in DNA accompanies a significant mutagenic consequence and is regulated at multiple levels, from the concentration of available dUTP in ...
Kim, Nayun +2 more
core +1 more source