Results 21 to 30 of about 26,862 (228)
Talanta Open, 2021 Hydrophilic interaction liquid chromatography using a zwitterionic phase, coupled with high-resolution mass spectrometry based on quadrupole and time-of-flight mass analyser (HILIC-Q-TOF-MS) is applied for the determination of four nucleobases (adenine ...
Marta Pastor-Belda +5 more
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Statistical analysis of readthrough levels for nonsense mutations in mammalian cells reveals a major determinant of response to gentamicin. [PDF]
PLoS Genetics, 2012 The efficiency of translation termination depends on the nature of the stop codon and the surrounding nucleotides. Some molecules, such as aminoglycoside antibiotics (gentamicin), decrease termination efficiency and are currently being evaluated for ...
Célia Floquet +3 more
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Disease Models & Mechanisms, 2022 RNA regulation in mammalian cells requires complex physical compartmentalisation, using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases.
Selma Gulyurtlu +6 more
doaj +1 more source
The Importance of the Fifth Nucleotide in DNA: Uracil
, 2023 Uracil is a ribonucleotide found in both DNA and RNA, with the main difference between the two being the presence of thymine in DNA and uracil in RNA. Although thymine and uracil are similar in function and can form the same base pairs with adenine, the presence of uracil in DNA can affect DNA stability and modulate cell-specific functions.
Roberts, Jamie Z., LaBonte , Melissa J.
openaire +2 more sources
Double‐Headed Nucleotides with Increased Base‐Pairing Affinity and Specificity [PDF]
, 2021 Double-headed nucleotides, i. e., nucleotides that hold two nucleobases each, have been shown to be double-functional in DNA duplexes by forming two sets of Watson−Crick base pairs, and thus mimicking dinucleotides.
Beck, Kasper Munch +9 more
core +1 more source
Interactions of Some Divalent Metal Ions with Thymine and Uracil Thiosemicarbazide Derivatives [PDF]
, 2016 The study of interactions between metal ions and nucleobases, nucleosides, nucleotides, or nucleic acids has become an active research area in chemical, biological, and therapeutic fields.
El-Dakdouki, Mohammad H. +4 more
core +1 more source
Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress [PDF]
Biochemical Pharmacology, 2005 Cardiomyocytes express one or more subtypes of P2 receptors for extracellular nucleotides. P2 purinoceptors, which are activated by nucleotides, are classified as P2X or P2Y: P2X receptors are ligand-gated intrinsic ion channels, and P2Y receptors are G protein-coupled receptors.
Smadar, Yitzhaki +3 more
openaire +2 more sources
Turning On Uracil-DNA Glycosylase Using a Pyrene Nucleotide Switch [PDF]
Journal of Biological Chemistry, 2001 Base flipping is a highly conserved process by which enzymes swivel an entire nucleotide from the DNA base stack into their active site pockets. Uracil DNA glycosylase (UDG) is a paradigm enzyme that uses a base flipping mechanism to catalyze the hydrolysis of the N-glycosidic bond of 2'-deoxyuridine (2'-dUrd) in DNA as the first step in uracil base ...
Y L, Jiang, K, Kwon, J T, Stivers
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Short Term Effect of Caffeine on Purine, Pyrimidine and Pyridine Metabolism in Rice () Seedlings
Natural Product Communications, 2015 As part of our studies on the physiological and ecological function of caffeine, we investigated the effect of exogenously supplied caffeine on purine, pyrimidine and pyridine metabolism in rice seedlings.
Wei-Wei Deng +2 more
doaj +1 more source
Journal of the World Aquaculture Society, 2023 A two‐factorial experiment (temperature with three levels: 23°C, 25.5°C and 28°C; diet with four kinds: live Artemia sp., copepods, live Artemia sp. + copepods and frozen Neomysis awatschensis [FNA]) was carried out to evaluate the effects of different ...
Xin Liu +4 more
doaj +1 more source