Results 21 to 30 of about 107,812 (233)
Disease Models & Mechanisms, 2022 RNA regulation in mammalian cells requires complex physical compartmentalisation, using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases.
Selma Gulyurtlu +6 more
doaj +1 more source
A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine [PDF]
, 2014 We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzyme’s active ...
Fox, Keith R. +11 more
core +2 more sources
Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39
Frontiers in Microbiology, 2018 Pyrimidine nucleotides play an important role in the biosynthesis of activated nucleotide sugars (NDP-sugars). NDP-sugars are the precursors of structural polysaccharides in bacteria, including capsule, which is a major virulence factor of the human ...
Sandra M. Carvalho +8 more
doaj +1 more source
Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress [PDF]
Biochemical Pharmacology, 2005 Cardiomyocytes express one or more subtypes of P2 receptors for extracellular nucleotides. P2 purinoceptors, which are activated by nucleotides, are classified as P2X or P2Y: P2X receptors are ligand-gated intrinsic ion channels, and P2Y receptors are G protein-coupled receptors.
Smadar, Yitzhaki +3 more
openaire +2 more sources
Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase [PDF]
, 2013 Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis.
Cole, Ambrose R. +11 more
core +1 more source
Short Term Effect of Caffeine on Purine, Pyrimidine and Pyridine Metabolism in Rice () Seedlings
Natural Product Communications, 2015 As part of our studies on the physiological and ecological function of caffeine, we investigated the effect of exogenously supplied caffeine on purine, pyrimidine and pyridine metabolism in rice seedlings.
Wei-Wei Deng +2 more
doaj +1 more source
Journal of the World Aquaculture Society, 2023 A two‐factorial experiment (temperature with three levels: 23°C, 25.5°C and 28°C; diet with four kinds: live Artemia sp., copepods, live Artemia sp. + copepods and frozen Neomysis awatschensis [FNA]) was carried out to evaluate the effects of different ...
Xin Liu +4 more
doaj +1 more source
Structure Characterization of Escherichia coli Pseudouridine Kinase PsuK
Frontiers in Microbiology, 2022 Pseudouridine (Ψ) is one of the most abundant RNA modifications in cellular RNAs that post-transcriptionally impact many aspects of RNA. However, the metabolic fate of modified RNA nucleotides has long been a question. A pseudouridine kinase (PsuK) and a
Xiaojia Li +7 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2020 Analysis of synonymous mutations established that although the primary amino acid sequence remains unchanged, alterations in transcription and translation can result in significant phenotypic consequences. We report the novel observation that a series of
Hadiar Rahman +8 more
doaj +1 more source
Nature Communications, 2023 Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive.
Chia-Shin Yang +5 more
doaj +1 more source