Results 1 to 10 of about 130,171 (160)

Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis

Marine Drugs, 2014
Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes.
Ri-Ming Huang, Yin-Ning Chen, Ziyu Zeng, Cheng-Hai Gao, Xiangdong Su, Yan Peng   +5 more
doaj   +2 more sources

Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese.

PLoS ONE, 2013
Urinary nucleosides are associated with many types of cancer. In this study, six targeted urinary nucleosides, namely adenosine, cytidine, 3-methylcytidine, 1-methyladenosine, inosine, and 2-deoxyguanosine, were chosen to evaluate their role as ...
Wei-Yi Hsu, Chao-Jung Chen, Yu-Chuen Huang, Fuu-Jen Tsai, Long-Bin Jeng, Chien-Chen Lai   +5 more
doaj   +2 more sources

Pyrrolo[2,3‐d]pyrimidine (7‐deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides

Medicinal Research Reviews, 2017
7‐Deazapurine (pyrrolo[2,3‐d]pyrimidine) nucleosides are important analogues of biogenic purine nucleosides with diverse biological activities. Replacement of the N7 atom with a carbon atom makes the five‐membered ring more electron rich and brings a ...
Pavla Perlíková, Michal Hocek
exaly   +2 more sources

Simultaneous Quantification of Nucleosides and Nucleotides from Biological Samples

Journal of the American Society for Mass Spectrometry, 2019
We report a reverse phase chromatography mass spectrometry (LC-MS) method for simultaneous quantification of nucleosides and nucleotides from biological samples, where compound identification was achieved by a tier-wise approach and compound ...
Liqing He, Xiaoli Wei, Xipeng Ma
exaly   +2 more sources

Pyrimidine nucleoside: inspiration for novel antimicrobial agent [PDF]

Frontiers in Pharmacology
Antimicrobial resistance (AMR) is a worsening global health crisis, with drug repurposing emerging as a key mitigation strategy. Pyrimidine nucleosides are promising antibacterial scaffolds due to their easily modifiable structures and multi-therapeutic ...
Binjie Xu, Binjie Xu, Pengyu Li, Jiping Liu, Mingkai Li   +4 more
doaj   +2 more sources

Structure–Activity Relationships, Molecular Mechanisms, and Ecotoxicological Evaluation Underlying Nucleoside-Mediated Antifouling Activity [PDF]

Biomolecules
Marine biofouling remains a major challenge for maritime industries, affecting submerged structures and vessels worldwide. The long-standing reliance on biocidal coatings, together with their documented environmental impacts, has led to increasingly ...
Sandra Pereira, Isabel B. Oliveira, Andreia Palmeira, Maria V. Turkina, Vitor Vasconcelos, Alexandre Campos, Joana R. Almeida   +6 more
doaj   +2 more sources

Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides

Molecules, 2015
Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
doaj   +2 more sources

Synthesis and Antimicrobial, Anticancer and Anti-Oxidant Activities of Novel 2,3-Dihydropyrido[2,3-d]pyrimidine-4-one and Pyrrolo[2,1-b][1,3]benzothiazole Derivatives via Microwave-Assisted Synthesis

Molecules, 2022
In our attempt towards the synthesis and development of effective antimicrobial, anticancer and antioxidant agents, a novel series of 2,3-dihydropyrido[2,3-d]pyrimidin-4-one 7a–e and pyrrolo[2,1-b][1,3]benzothiazoles 9a–e were synthesized.
Aamal A. Al-Mutairi, Hend N. Hafez, Abdel-Rhaman B. A. El-Gazzar, Marwa Y. A. Mohamed   +3 more
doaj   +1 more source

Lactiplantibacillus plantarum enables blood urate control in mice through degradation of nucleosides in gastrointestinal tract

Microbiome, 2023
Background Lactobacillus species in gut microbiota shows great promise in alleviation of metabolic diseases. However, little is known about the molecular mechanism of how Lactobacillus interacts with metabolites in circulation.
Meng-Fan Li, Xiao-ling Wu, Zewang Guo, Ruichen Gao, Zifu Ni, Hua-Ling Cui, Min-hua Zong, F. Van Bockstaele, Wenyong Lou   +8 more
semanticscholar   +1 more source

COMPLEX-FORMING PROPERTIES OF SYNTHETIC PYRIMIDINONE NUCLEOSIDES WITH Ag(I) IONS IN AN AQUEOUS SOLUTION [PDF]

Acta Poloniae Pharmaceutica, 2023
The present work describes the complexation properties of two synthetic nucleosides (used as ligands), i.e. β-D-ribofuranoside-4-pyrimidinone (ribo) and β-D-deoxyribofuranoside-4-pyrimidinone (deoxy) with Ag(I) ions in aqueous solution.
Marek Pająk, Magdalena Woźniczka, Mirosława Świątek, Bartłomiej Czerwiński, Jakub Włodarczyk, Jakub Fichna   +5 more
doaj   +1 more source