Results 11 to 20 of about 130,320 (304)
Advance of structural modification of nucleosides scaffold
European journal of medicinal chemistry, 2021 With Remdesivir being approved by FDA as a drug for the treatment of Corona Virus Disease 2019 (COVID-19), nucleoside drugs have once again received widespread attention in the medical community.
Xia Lin +6 more
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Diversification of 4′-Methylated Nucleosides by Nucleoside Phosphorylases [PDF]
ACS Catalysis, 2021 The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies. Herein, we report the development of a biocatalytic diversification approach based on nucleoside phosphorylases, which allows the ...
Felix Kaspar +11 more
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Sensors, 2006 A rigid molecular clip comprising bisphosphonate binding sites and aromaticsidewalls forming an electron-rich cavity is able to distinguish between nucleosides andnucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereofare drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the 1HNMR
Fokkens, Michael +2 more
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SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES [PDF]
Biotechnologia Acta, 2013 Some recent findings in the biotechnology of biologically important nucleosides will be discussed, viz., (i) a new strategy of the cascade one-pot transformation of D-pentoses into nucleosides based on the extension and deepening of the knowledge of the ...
A. Mikhailopulo, A. I. Miroshnikov
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Green Synthesis and Catalysis, 2020 Both O-glycosides and nucleosides are essential biomolecules with important roles in a variety of biological processes. Chemical synthesis of both O-glycosides and nucleosides is a scalable and reliable method to develop new therapeutic agents and ...
Penghua Li +7 more
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Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides
Nature, 2020 The nature of the first genetic polymer is the subject of major debate1. Although the ‘RNA world’ theory suggests that RNA was the first replicable information carrier of the prebiotic era—that is, prior to the dawn of life2,3—other evidence implies that
Jianfeng Xu +8 more
semanticscholar +1 more source
Nature Communications, 2020 Both of O-glycosides and nucleosides are important biomolecules with crucial rules in numerous biological processes. Chemical synthesis is an efficient and scalable method to produce well-defined and pure carbohydrate-containing molecules for deciphering
Penghua Li +8 more
semanticscholar +1 more source
Radiosensitizing Nucleosides [PDF]
JNCI Journal of the National Cancer Institute, 1996 Chemotherapeutic drugs that perturb nucleotide metabolism have the potential to produce substantial sensitization of tumor cells to radiation treatment. The process is called radiosensitization, and the agents that induce it are called radiosensitizers.
C J, McGinn, D S, Shewach, T S, Lawrence
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Strained Conformations of Nucleosides in Active Sites of Nucleoside Phosphorylases
Biomolecules, 2020 Nucleoside phosphorylases catalyze the reversible phosphorolysis of nucleosides to heterocyclic bases, giving α-d-ribose-1-phosphate or α-d-2-deoxyribose-1-phosphate. These enzymes are involved in salvage pathways of nucleoside biosynthesis. The level of
Irina A. Il’icheva +2 more
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