Results 31 to 40 of about 130,320 (304)

Determination and comparative analysis of 13 nucleosides and nucleobases in natural fruiting body of Ophiocordyceps sinensis and its substitutes

open access: yesMycology, 2017
Nucleosides and nucleobases are one of the most important indicators of quality control. A sensitive and reliable high performance liquid chromatography-ultraviolet method was applied to analyse 13 nucleosides and nucleobases simultaneously in 15 batches
Wenming Cheng   +6 more
doaj   +1 more source

Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology

open access: yesQuímica Nova, 2004
The preparation of 2', 3'-di-O-hexanoyluridine (2) by a Candida antarctica B lipase-catalysed alcoholysis of 2', 3', 5'-tri-O-hexanoyluridine (1) was optimised using an experimental design.
María A. Zinni   +3 more
doaj   +1 more source

Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs

open access: yesbioRxiv, 2018
Post-transcriptional nucleoside modifications have long been recognized as key modulators of non-coding RNA structure and function. There is an emerging appreciation that the chemical modification of protein-coding messenger RNAs (mRNAs) also plays ...
M. Tardu, Q. Lin, Kristin S. Koutmou
semanticscholar   +1 more source

Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

open access: yesMolecules, 2014
The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyl)adenosine or a 1,6-di(adenosin-N6-yl)-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamine)platinum(II), is reported.
Stefano D'Errico   +10 more
doaj   +1 more source

A One-Pot Approach to Novel Pyridazine C-Nucleosides

open access: yesMolecules, 2021
The synthesis of glycosides and modified nucleosides represents a wide research field in organic chemistry. The classical methodology is based on coupling reactions between a glycosyl donor and an acceptor.
Flavio Cermola   +4 more
doaj   +1 more source

Fast Simultaneous Determination of 13 Nucleosides and Nucleobases in Cordyceps sinensis by UHPLC–ESI–MS/MS

open access: yesMolecules, 2015
A reliable ultra-high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (UHPLC–ESI–MS/MS) method for the fast simultaneous determination of 13 nucleosides and nucleobases in Cordyceps sinensis (C.
Shi-Yu Zong   +6 more
doaj   +1 more source

Nucleosides 8 [18]: Ribosylation of Fused Quinazolines—Synthesis of New [1,2,4]Triazolo[5,1-b]- and [1,2,4]Triazino[3,2-b]quinazoline Nucleosides of Fluorescence Interest

open access: yesJournal of Chemistry, 2013
[1,2,4]Triazolo[5,1-b]- and [1,2,4]triazino[3,2-b] quinazolines have been ribosylated by coupling with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose and by using the silylation method, followed by debenzoylation by methanolic sodium methoxide to afford
Laila Mohamed Break   +2 more
doaj   +1 more source

Simultaneous Determination of Methylated Nucleosides by HILIC–MS/MS Revealed Their Alterations in Urine from Breast Cancer Patients

open access: yesMetabolites, 2022
RNA methylation plays a vital role in the pathogenesis of a variety of diseases including cancer, and aberrant levels of modified nucleosides in RNA were revealed to be related to cancer.
Zhihao Fang   +7 more
doaj   +1 more source

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

open access: yeseLife, 2014
Concentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules. CNTs also play a crucial role in the uptake of nucleoside-derived drugs, including anticancer and antiviral agents.
Zachary Lee Johnson   +6 more
openaire   +3 more sources

Taurine Bromamine: Reactivity of an Endogenous and Exogenous Anti-Inflammatory and Antimicrobial Amino Acid Derivative

open access: yesBiomolecules, 2016
Taurine bromamine (Tau-NHBr) is produced by the reaction between hypobromous acid (HOBr) and the amino acid taurine. There are increasing number of applications of Tau-NHBr as an anti-inflammatory and microbicidal drug for topical usage.
Luiza De Carvalho Bertozo   +3 more
doaj   +1 more source

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