Results 31 to 40 of about 37,185 (261)

Determination and comparative analysis of 13 nucleosides and nucleobases in natural fruiting body of Ophiocordyceps sinensis and its substitutes

open access: yesMycology, 2017
Nucleosides and nucleobases are one of the most important indicators of quality control. A sensitive and reliable high performance liquid chromatography-ultraviolet method was applied to analyse 13 nucleosides and nucleobases simultaneously in 15 batches
Wenming Cheng   +6 more
doaj   +1 more source

Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology

open access: yesQuímica Nova, 2004
The preparation of 2', 3'-di-O-hexanoyluridine (2) by a Candida antarctica B lipase-catalysed alcoholysis of 2', 3', 5'-tri-O-hexanoyluridine (1) was optimised using an experimental design.
María A. Zinni   +3 more
doaj   +1 more source

Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

open access: yesMolecules, 2014
The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyl)adenosine or a 1,6-di(adenosin-N6-yl)-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamine)platinum(II), is reported.
Stefano D'Errico   +10 more
doaj   +1 more source

Fast Simultaneous Determination of 13 Nucleosides and Nucleobases in Cordyceps sinensis by UHPLC–ESI–MS/MS

open access: yesMolecules, 2015
A reliable ultra-high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (UHPLC–ESI–MS/MS) method for the fast simultaneous determination of 13 nucleosides and nucleobases in Cordyceps sinensis (C.
Shi-Yu Zong   +6 more
doaj   +1 more source

Nucleosides 8 [18]: Ribosylation of Fused Quinazolines—Synthesis of New [1,2,4]Triazolo[5,1-b]- and [1,2,4]Triazino[3,2-b]quinazoline Nucleosides of Fluorescence Interest

open access: yesJournal of Chemistry, 2013
[1,2,4]Triazolo[5,1-b]- and [1,2,4]triazino[3,2-b] quinazolines have been ribosylated by coupling with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose and by using the silylation method, followed by debenzoylation by methanolic sodium methoxide to afford
Laila Mohamed Break   +2 more
doaj   +1 more source

A One-Pot Approach to Novel Pyridazine C-Nucleosides

open access: yesMolecules, 2021
The synthesis of glycosides and modified nucleosides represents a wide research field in organic chemistry. The classical methodology is based on coupling reactions between a glycosyl donor and an acceptor.
Flavio Cermola   +4 more
doaj   +1 more source

Simultaneous Determination of Methylated Nucleosides by HILIC–MS/MS Revealed Their Alterations in Urine from Breast Cancer Patients

open access: yesMetabolites, 2022
RNA methylation plays a vital role in the pathogenesis of a variety of diseases including cancer, and aberrant levels of modified nucleosides in RNA were revealed to be related to cancer.
Zhihao Fang   +7 more
doaj   +1 more source

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

open access: yeseLife, 2014
Concentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules. CNTs also play a crucial role in the uptake of nucleoside-derived drugs, including anticancer and antiviral agents.
Zachary Lee Johnson   +6 more
openaire   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Taurine Bromamine: Reactivity of an Endogenous and Exogenous Anti-Inflammatory and Antimicrobial Amino Acid Derivative

open access: yesBiomolecules, 2016
Taurine bromamine (Tau-NHBr) is produced by the reaction between hypobromous acid (HOBr) and the amino acid taurine. There are increasing number of applications of Tau-NHBr as an anti-inflammatory and microbicidal drug for topical usage.
Luiza De Carvalho Bertozo   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy