Results 21 to 30 of about 37,185 (261)
Strained Conformations of Nucleosides in Active Sites of Nucleoside Phosphorylases
Biomolecules, 2020 Nucleoside phosphorylases catalyze the reversible phosphorolysis of nucleosides to heterocyclic bases, giving α-d-ribose-1-phosphate or α-d-2-deoxyribose-1-phosphate. These enzymes are involved in salvage pathways of nucleoside biosynthesis. The level of
Irina A. Il’icheva +2 more
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Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters
Pharmacology Research & Perspectives, 2021 Acute lymphoblastic leukemia (ALL) is the most common cancer in children and adolescents. Although the 5‐year survival rate is high, some patients respond poorly to chemotherapy or have recurrence in locations such as the testis. The blood–testis barrier
Siennah R. Miller +7 more
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Metabolites, 2021 Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential ...
Kuei-Hung Lai +9 more
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Molecules, 2013 An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine ...
Roger Stromberg, Jyotirmoy Maity
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Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese.
PLoS ONE, 2013 Urinary nucleosides are associated with many types of cancer. In this study, six targeted urinary nucleosides, namely adenosine, cytidine, 3-methylcytidine, 1-methyladenosine, inosine, and 2-deoxyguanosine, were chosen to evaluate their role as ...
Wei-Yi Hsu +5 more
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Frontiers in Molecular Biosciences, 2023 The morbidity and mortality of colorectal cancer (CRC) have been increasing in recent years, and early detection of CRC can improve the survival rate of patients. RNA methylation plays crucial roles in many biological processes and has been implicated in
Weifang Zheng +9 more
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Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis
Marine Drugs, 2014 Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes.
Ri-Ming Huang +5 more
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BMC Plant Biology, 2017 Background Modification of nucleosides on transfer RNA (tRNA) is important either for correct mRNA decoding process or for tRNA structural stabilization.
Youmei Wang +6 more
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Synthesis of Natural Product-Like Tricyclic Higher-Carbon Sugar Nucleosides
Pharmaceutical Fronts, 2021 Because of the structural novelty and interesting biological profiles, the synthesis of higher-carbon sugars has been highly pursued. In this work, we first synthesized a series of structurally novel bis-uracil containing tricyclic higher-carbon sugar ...
Xiao-Han Yuan +4 more
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Frontiers in Veterinary Science, 2020 An in ovo study on the effect of the administration of a combination of nucleosides (25, 50, and 100 mg/egg) on hatchability, growth performance, energy metabolizability, and intestinal morphology in broilers was carried out.
Marappan Gopi +9 more
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