Results 21 to 30 of about 58,095 (298)

Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]

, 2012
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Claire M. Peppiatt-Wildman, Scott-Ward, Toby S., Alberto Contreras-Sanz, Kevin M. G. Taylor, Malone-Lee, James, Wildman, Scott S.P., Rebecca E. Birch, Scott S. P. Wildman, James Malone-Lee, Jennifer C. Jacoby, Taylor, Kevin M. G., Gill, Hardyal S., Peppiatt-Wildman, Claire M., Birch, Rebecca E., Contreras-Sanz, Alberto, Hardyal S. Gill, Toby S. Scott-Ward, Jacoby, Jennifer C., Wildman, Scott S. P.   +18 more
core   +1 more source

Synthesis and Base Pairing Properties of Platinum(II) Nucleosides Based on Uracil [PDF]

, 2023
The synthesis and base pairing properties of platinum complexes based on uridine and deoxyuridine nucleosides are described. The synthesis was performed by C–I oxidative addition with protected and unprotected nucleosides.
Federico, Herrera, Fernanda, Murtinheira, Ana, Petronilho, Maria Inês, Leitão, Giulia, Orsini, Clara, Gomes   +5 more
core   +2 more sources

Synthesis and Antiproliferative Evaluation of Novel D-Glucuronamide-based Nucleosides and (Triazolyl)methyl Amide-linked Pseudodisaccharide Nucleosides [PDF]

, 2023
The synthesis and antiproliferative evaluation of novel D-glucopyranuronamide-containing nucleosides is described. Based on our previously reported anticancer D-glucuronamide-based nucleosides, new analogues comprising N/O-dodecyl or N-propargyl ...
Joana, Rosa, Nuno Manuel, Xavier, Tânia , Moreira, Veronika , Vojáčková, M. Conceição, Oliveira, Rafael, Nunes, Domingos , Manuel, Radek , Jorda   +7 more
core   +1 more source

Determination and comparative analysis of 13 nucleosides and nucleobases in natural fruiting body of Ophiocordyceps sinensis and its substitutes

Mycology, 2017
Nucleosides and nucleobases are one of the most important indicators of quality control. A sensitive and reliable high performance liquid chromatography-ultraviolet method was applied to analyse 13 nucleosides and nucleobases simultaneously in 15 batches
Wenming Cheng, Xun Zhang, Qiang Song, Weili Lu, Tingni Wu, Qunlin Zhang, Chunru Li   +6 more
doaj   +1 more source

Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology

Química Nova, 2004
The preparation of 2', 3'-di-O-hexanoyluridine (2) by a Candida antarctica B lipase-catalysed alcoholysis of 2', 3', 5'-tri-O-hexanoyluridine (1) was optimised using an experimental design.
María A. Zinni, Ernesto M. Aljinovic, Luis E. Iglesias, Adolfo M. Iribarren   +3 more
doaj   +1 more source

Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

Molecules, 2014
The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyl)adenosine or a 1,6-di(adenosin-N6-yl)-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamine)platinum(II), is reported.
Stefano D'Errico, Giorgia Oliviero, Nicola Borbone, Vincenzo Piccialli, Brunella Pinto, Francesca De Falco, Maria Chiara Maiuri, Rosa Carnuccio, Valeria Costantino, Fabrizia Nici, Gennaro Piccialli   +10 more
doaj   +1 more source

Fast Simultaneous Determination of 13 Nucleosides and Nucleobases in Cordyceps sinensis by UHPLC–ESI–MS/MS

Molecules, 2015
A reliable ultra-high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (UHPLC–ESI–MS/MS) method for the fast simultaneous determination of 13 nucleosides and nucleobases in Cordyceps sinensis (C.
Shi-Yu Zong, Han Han, Bing Wang, Ning Li, Tina Ting-Xia Dong, Tong Zhang, Karl W. K. Tsim   +6 more
doaj   +1 more source

Nucleosides 8 [18]: Ribosylation of Fused Quinazolines—Synthesis of New [1,2,4]Triazolo[5,1-b]- and [1,2,4]Triazino[3,2-b]quinazoline Nucleosides of Fluorescence Interest

Journal of Chemistry, 2013
[1,2,4]Triazolo[5,1-b]- and [1,2,4]triazino[3,2-b] quinazolines have been ribosylated by coupling with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose and by using the silylation method, followed by debenzoylation by methanolic sodium methoxide to afford
Laila Mohamed Break, Mosselhi Abdelnabi Mosselhi, Nagi Mohamed Elshafai   +2 more
doaj   +1 more source

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

eLife, 2014
Concentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules. CNTs also play a crucial role in the uptake of nucleoside-derived drugs, including anticancer and antiviral agents.
Zachary Lee Johnson, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong, Seok-Yong Lee   +6 more
openaire   +3 more sources

In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions

Molecules, 2022
Inhibition of human DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) by different chiral lipophilic nucleoside derivatives was studied. New Tdp1 inhibitors were found in the series of the studied compounds with IC50 = 2.7–6.7 μM.
Nadezhda S. Dyrkheeva, Irina A. Chernyshova, Georgy A. Ivanov, Yuri B. Porozov, Anastasia A. Zenchenko, Vladimir E. Oslovsky, Alexandra L. Zakharenko, Darina I. Nasyrova, Galina N. Likhatskaya, Sergey N. Mikhailov, Olga I. Lavrik, Mikhail S. Drenichev   +11 more
doaj   +1 more source