Results 1 to 10 of about 282,363 (268)

Oligomeric Nucleic Acids as Antivirals

Molecules, 2011
Based on the natural functions and chemical characteristics of nucleic acids, a variety of novel synthetic drugs and tools to explore biological systems have become available in recent years.
Alessandra Mescalchin, Tobias Restle
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Triplex Hybridization-Based Nanosystem for the Rapid Screening of Pneumocystis Pneumonia in Clinical Samples

Journal of Fungi, 2020
Pneumocystis pneumonia (PcP) is a disease produced by the opportunistic infection of the fungus Pneumocystis jirovecii. As delayed or unsuitable treatments increase the risk of mortality, the development of rapid and accurate diagnostic tools for PcP are
Luis Pla, Anna Aviñó, Ramón Eritja, Alba Ruiz-Gaitán, Javier Pemán, Vicente Friaza, Enrique J. Calderón, Elena Aznar, Ramón Martínez-Máñez, Sara Santiago-Felipe   +9 more
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Modeling and Simulation Identifies Endocytosis Uptake Rate and Fraction Unbound as Important Predictors of Oligonucleotide Pharmacokinetics

CPT: Pharmacometrics & Systems Pharmacology
Therapeutic oligonucleotides (TOs) represent an emerging modality, which offers a promising alternative treatment option, particularly for intracellular targets.
Felix Stader, Abdallah Derbalah, Adriana Zyla, Cong Liu, Iain Gardner, Armin Sepp   +5 more
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Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media

Molecules, 2018
Deficient stability towards nuclease-mediated degradation is one of the most relevant tasks in the development of oligonucleotide-derived biomedical agents.
Melissa Meng, Boris Schmidtgall, Christian Ducho   +2 more
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New Insights into the Reaction Paths of Hydroxyl Radicals with Purine Moieties in DNA and Double-Stranded Oligodeoxynucleotides

Molecules, 2019
The reaction of hydroxyl radical (HO•) with DNA produces many primary reactive species and many lesions as final products. In this study, we have examined the optical spectra of intermediate species derived from the reaction of HO• with a ...
Chryssostomos Chatgilialoglu, Marios G. Krokidis, Annalisa Masi, Sebastian Barata-Vallejo, Carla Ferreri, Michael A. Terzidis, Tomasz Szreder, Krzysztof Bobrowski   +7 more
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Investigation of the Influence of Charge State and Collision Energy on Oligonucleotide Fragmentation by Tandem Mass Spectrometry

Molecules, 2023
Due to the increasing pharmaceutical interest of oligonucleotides, for example in antisense therapy and vaccines, their analytical characterization is of fundamental importance due to their complex structure.
Christopher Gawlig, Michael Rühl
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2018 FDA Tides Harvest

Pharmaceuticals, 2019
In 2018, the United States Food and Drug Administration (FDA) approved a total of 59 new drugs, three of them (5%) are TIDES (or also, -tides), two oligonucleotides and one peptide. Herein, the three TIDES approved are analyzed in terms of medical target,
Danah Al Shaer, Othman Al Musaimi, Fernando Albericio, Beatriz G. de la Torre   +3 more
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Antibacterial Peptide Nucleic Acids—Facts and Perspectives

Molecules, 2020
Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century.
Monika Wojciechowska, Marcin Równicki, Adam Mieczkowski, Joanna Miszkiewicz, Joanna Trylska   +4 more
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Single-Molecule Chemistry Part II: Pathway Analysis of the Oxidation of Guanine to 8-Oxo-7,8-dihydroguanosine in an Oligonucleotide Hybrid

Molecules
In a short 11 nt dye-labelled oligonucleotide hybrid, we investigated the oxidation of a single guanine, G, to 8-oxo-7,8-dihydroguanosine, 8oG, a reaction proceeding via two reaction pathways.
Jens Sobek, Marco Schmidt, Stephan Landgraf, Aaron Fleming, Kiyohiko Kawai, Ralph Schlapbach   +5 more
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RNA-based discovery and correction of splicing defects caused by POLR3A missense mutations

Molecular Therapy: Nucleic Acids
RNA polymerase III-related disorders represent a clinically diverse spectrum of diseases. While pathogenic variants in the POLR3A subunit are most commonly associated with hypomyelinating leukodystrophies, they also contribute to other neurological or ...
Lulzim Shkreta, Aurélie Delannoy, Johanne Toutant, James McSwiggen, Benoit Chabot   +4 more
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