Results 31 to 40 of about 312,210 (300)
Antisense oligonucleotides [PDF]
Neurology Genetics, 2019 There are few disease-modifying therapeutics for neurodegenerative diseases, but successes on the development of antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy and Duchenne muscular dystrophy predict a robust future for ASOs in medicine.
Scoles, Daniel R. +2 more
openaire +2 more sources
Acta Agriculturae Slovenica, 2008 One of the basic principles of molecular biology is the use oligonucleotides with comparable melting temperatures (Tm). To accommodate various evolutionary changes in target gene sequences in order to detect numerous variants of the same gene in complex ...
Blaž STRES, Boštjan MUROVEC
doaj +1 more source
Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]
, 2008 Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Alirio J. Melendez +3 more
core +1 more source
Emerging microRNA Therapeutic Approaches for Cystic Fibrosis
Frontiers in Pharmacology, 2018 Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs.
Pauline Bardin +4 more
doaj +1 more source
Development of whole body scanning PCR, a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides [PDF]
, 2015 Based on RNA interference (RNAi), a mechanism regulating gene expression at the post-transcriptional level in eukaryotes, therapeutic siRNAs are slowly moving towards late phase clinical trials.
Boos, Julien Alfred Jean-Paul
core +1 more source
Pharmacological Activity and Clinical Use of PDRN
Frontiers in Pharmacology, 2017 PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers.
Francesco Squadrito +6 more
doaj +1 more source
Hybridization of surface-tethered oligonucleotide brushes [PDF]
, 2009 Part 1. Introduction In this chapter the chemical structures of DNA and oligonucleotides as building materials for subsequent use in biosensor application are described. The general concepts of modern DNA-based biosensors are presented and the commonly
Razumovitch, Julia
core +1 more source
Frontiers in Microbiology, 2019 Optical biosensors for rapid detection of significant foodborne pathogens are steadily gaining popularity due to its simplicity and sensitivity. While nanomaterials such as gold nanoparticles (AuNPs) are commonly used as signal amplifiers for optical ...
Irwin A. Quintela +5 more
doaj +1 more source
Biosensors, 2021 Enteroviruses are ubiquitous mammalian pathogens that can produce mild to life-threatening disease. We developed a multimodal, rapid, accurate and economical point-of-care biosensor that can detect nucleic acid sequences conserved amongst 96% of all ...
Veeren M. Chauhan +5 more
doaj +1 more source
CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity
, 2012 In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Franch i Masferrer, Àngels +6 more
core +1 more source