Results 21 to 30 of about 282,363 (268)
Chemical synthesis of oligonucleotides using acetone as a washing solvent
BioTechniques, 2009 Acetone is being proposed as the main washing solvent during automated synthesis of oligonucleotides to reduce acetonitrile usage in the assembly process and endure the impact of global acetonitrile shortage.
Paul Gaytán
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Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection
Frontiers in Immunology, 2020 Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children. Currently, there is no RSV vaccine or universally accessible antiviral treatment available. Addressing the urgent need for new antiviral
Sandra Axberg Pålsson +14 more
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Acta Agriculturae Slovenica, 2008 One of the basic principles of molecular biology is the use oligonucleotides with comparable melting temperatures (Tm). To accommodate various evolutionary changes in target gene sequences in order to detect numerous variants of the same gene in complex ...
Blaž STRES, Boštjan MUROVEC
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Emerging microRNA Therapeutic Approaches for Cystic Fibrosis
Frontiers in Pharmacology, 2018 Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs.
Pauline Bardin +4 more
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Pharmacological Activity and Clinical Use of PDRN
Frontiers in Pharmacology, 2017 PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers.
Francesco Squadrito +6 more
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Frontiers in Microbiology, 2019 Optical biosensors for rapid detection of significant foodborne pathogens are steadily gaining popularity due to its simplicity and sensitivity. While nanomaterials such as gold nanoparticles (AuNPs) are commonly used as signal amplifiers for optical ...
Irwin A. Quintela +5 more
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Biosensors, 2021 Enteroviruses are ubiquitous mammalian pathogens that can produce mild to life-threatening disease. We developed a multimodal, rapid, accurate and economical point-of-care biosensor that can detect nucleic acid sequences conserved amongst 96% of all ...
Veeren M. Chauhan +5 more
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ChemistryOpen, 2020 DNA was used as supramolecular scaffold to order chromophores and control their optical properties. Ethynylpyrene as energy donor was attached to 2′‐desoxy‐2‐aminoadenosine that binds selectively to thymidines (T) in the template.
Sara Müller +2 more
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
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