Results 11 to 20 of about 330,852 (300)
Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]
, 2008 Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Mansoor, Moizza, Melendez, Alirio J.
core +5 more sources
Making Oligonucleotide Conjugates and Breaking Oligonucleotides [PDF]
Nucleic Acids Symposium Series, 2007 Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2'-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups.
S, Milton +4 more
openaire +2 more sources
, 2023 Oligonucleotides used in this study. All oligonucleotides were synthesized by IDT (Integrated DNA technologies Europe, BVBA, Leuven, Belgium). (XLSX)
Jingchan Xie (16859288) +5 more
core +2 more sources
Synthesis and anti-HIV activity of thiocholesteryl-coupled phosphodiester antisense oligonucleotides incorporated into immunoliposomes [PDF]
, 1994 Encapsulation of oligonucleotides in antibody-targeted liposomes (immunoliposomes) which bind to target cells permits intracellular delivery of the oligonucleotides.
Zelphati, Olivier +2 more
core +1 more source
CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity [PDF]
, 2012 In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Ciudad i Gómez, Carlos Julián +6 more
core +1 more source
Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection
Frontiers in Immunology, 2020 Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children. Currently, there is no RSV vaccine or universally accessible antiviral treatment available. Addressing the urgent need for new antiviral
Sandra Axberg Pålsson +14 more
doaj +1 more source
Acta Agriculturae Slovenica, 2008 One of the basic principles of molecular biology is the use oligonucleotides with comparable melting temperatures (Tm). To accommodate various evolutionary changes in target gene sequences in order to detect numerous variants of the same gene in complex ...
Blaž STRES, Boštjan MUROVEC
doaj +1 more source
Selective Functionalization at N2-Position of Guanine in Oligonucleotides via Reductive Amination [PDF]
, 2020 Chemo- and site-specific modifications in oligonucleotides have wide applicability as mechanistic probes in chemical biology. Here we have employed a classical reaction in organic chemistry, reductive amination, to selectively functionalize the N2-amine ...
Bapurao, Bhoge, Ishu, Saraogi
core +1 more source
Emerging microRNA Therapeutic Approaches for Cystic Fibrosis
Frontiers in Pharmacology, 2018 Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs.
Pauline Bardin +4 more
doaj +1 more source