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Diversification of 4′-Methylated Nucleosides by Nucleoside Phosphorylases [PDF]
ACS Catalysis, 2021 The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies. Herein, we report the development of a biocatalytic diversification approach based on nucleoside phosphorylases, which allows the ...
Felix Kaspar +11 more
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Role of Nucleoside Transporters in Nucleoside-Derived Drug Sensitivity [PDF]
Nucleosides, Nucleotides and Nucleic Acids, 2010 Nucleoside-derived drugs are currently used clinically as anticancer drugs. To exert their pharmacological action first they need to enter into the cell across plasma membrane transporters and be metabolized. Thus, efficacy of treatment and acquisition of resistance can rely on a variety of events.
Molina-Arcas M, Pastor-Anglada M
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eLife, 2014 Concentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules.
Zachary Lee Johnson +6 more
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Molecules, 2022 The chemistry and biochemistry of carbohydrate esters are essential parts of biochemical and medicinal research. A group of methyl β-d-galactopyranoside (β-MGP, 1) derivatives was acylated with 3-bromobenzoyl chloride and 4-bromobenzoyl chloride in ...
Faez Ahmmed +6 more
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Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. [PDF]
, 2022 INTRODUCTION: Nucleoside analogues represent a cornerstone of achievement in drug discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery over the last 60 years.
Miller, Gavin J.; id_orcid +2 more
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Nucleoside-Derived Metallohydrogel Induces Cell Death in Leishmania Parasites [PDF]
, 2023 Self-assembled hydrogels by virtue of their unique 3D network and tunability have extensively been explored for bio-medical applications like tissue engineering, delivery and release of therapeutic agents, etc.
Jyotirmayee Dash (1616845) +9 more
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Shipin gongye ke-ji, 2023 To provide a scientific basis for the follow-up resource utilization and food development of Jinzhai hybrid G. elata, the ultra-high performance liquid chromatography coupled with mass spectrometry was utilized to accurately determine the contents of ...
Guangzheng WANG +5 more
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Sensors, 2006 A rigid molecular clip comprising bisphosphonate binding sites and aromaticsidewalls forming an electron-rich cavity is able to distinguish between nucleosides andnucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereofare drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the 1HNMR
Fokkens, Michael +2 more
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Industrial potential of the enzymatic synthesis of nucleoside analogs: Existing challenges and perspectives [PDF]
, 2022 Nucleoside phosphorylases have progressed from an enzymatic curiosity to a viable synthetic tool. However, despite the recent advances in nucleoside phosphorylase-catalyzed nucleoside synthesis, the widespread application of these enzymes in industrial ...
Anke, Kurreck +3 more
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