Results 11 to 20 of about 173,532 (309)
Generative AI Design and Exploration of Nucleoside Analogs [PDF]
, 2021 Nucleosides are fundamental building blocks of DNA and RNA in all life forms and viruses. In addition, natural nucleosides and their analogs are critical in prebiotic chemistry, innate immunity, signaling, antiviral drug discovery and artificial ...
Damien, Dablain +2 more
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Radiosensitizing Nucleosides [PDF]
JNCI Journal of the National Cancer Institute, 1996 Chemotherapeutic drugs that perturb nucleotide metabolism have the potential to produce substantial sensitization of tumor cells to radiation treatment. The process is called radiosensitization, and the agents that induce it are called radiosensitizers.
C J, McGinn, D S, Shewach, T S, Lawrence
openaire +2 more sources
Sustainable flow‐synthesis of (bulky)nucleoside drugs by a novel and highly stable nucleoside phosphorylase immobilized on reusable supports [PDF]
, 2022 The continuous synthesis of valuable nucleoside drugs was achieved in up to 99% conversion by using a novel halotolerant purine nucleoside phosphorylase from Halomonas elongata (HePNP).
Ana I. Benítez‐Mateos +4 more
core +1 more source
Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents
Pharmaceuticals, 2022 Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Franck Amblard +11 more
doaj +1 more source
18Oxygen Substituted Nucleosides Combined with Proton Beam Therapy: Therapeutic Transmutation In Vitro [PDF]
International Journal of Particle Therapy, 2021 Purpose: Proton therapy precisely delivers radiation to cancers to cause damaging strand breaks to cellular DNA, kill malignant cells, and stop tumor growth.
Tyvin Rich, MD +9 more
doaj +1 more source
Nucleoside-Derived Low-Molecular-Weight Gelators as a Synthetic Microenvironment for 3D Cell Culture [PDF]
, 2022 For the last few decades, many efforts have been made in developing cell culture methods in order to overcome the biological limitations of the conventional two-dimensional culture.
Tarek Saydé (11401257) +23 more
core +1 more source
Squalen, 2023 The quality of fish freshness plays a crucial role in the acceptance of consumers and human health. Considering that food safety has recently become a major concern on a global scale, establishing and evaluating fish freshness is crucial for research and
Giri Rohmad Barokah +3 more
doaj +1 more source
Inhibition of Ubiquitin Phosphorylation by Nucleoside Analogues [PDF]
, 2022 The phosphorylation of ubiquitin by the mitochondrial protein kinase PINK1, upon mitochondrial depolarization, is an important step in the repair and recycling of the mitochondria via mitophagy.
Olivia A, Lambourne +13 more
core +1 more source
Molecules, 2022 Molecular mechanics force field calculations have historically shown significant limitations in modeling the energetic and conformational interconversions of highly substituted furanose rings. This is primarily due to the gauche effect that is not easily
Diego E. Escalante +2 more
doaj +1 more source
Oxalyl retro-peptide gelators. Synthesis, gelation properties and stereochemical effects
Beilstein Journal of Organic Chemistry, 2010 In this work we report on gelation properties, self-assembly motifs, chirality effects and morphological characteristics of gels formed by chiral retro-dipeptidic gelators in the form of terminal diacids (1a–5a) and their dimethyl ester (1b–5b) and ...
Janja Makarević +5 more
doaj +1 more source