Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
Molecules, 2013 Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential
Philippe Barthélémy +3 more
doaj +1 more source
Nucleoside Phosphorylases Make N7-Xanthosine, the “Non-native” Regioisomer of Xanthosine [PDF]
, 2023 Modern, highly evolved, nucleoside-processing enzymes are known to exhibit perfect regioselectivity over the glycosylation of purine nucleobases at N9. We herein report an exception to this paradigm.
Anke, Kurreck +9 more
core +1 more source
Nucleic Acid Based Fluorinated Derivatives: New Tools for Biomedical Applications
Applied Sciences, 2012 Nucleic acid-based fluorinated derivatives, e.g., nucleosides or oligonucleotides connected to highly fluorinated chains or labeled with one or more fluorine atoms, have been investigated recently due to their high potential for biomedical applications ...
Christel Dolain +3 more
doaj +1 more source
Molecules, 2017 Background: Poor pharmacokinetic profiles and resistance are the main two drawbacks from which currently used antiviral agents suffer, thus make them excellent targets for research, especially in the presence of viral pandemics such as HIV and hepatitis ...
Hanadi Sinokrot +3 more
doaj +1 more source
Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]
, 2010 <b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
Neils B Quashie +8 more
core +1 more source
Biomolecules, 2020 Molecular modeling has contributed to drug discovery for purinergic GPCRs, including adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and homology modeling have proven to be useful in understanding and predicting structure ...
Veronica Salmaso, Kenneth A. Jacobson
doaj +1 more source
Nucleoside Analog 2′,3′-Isopropylidene-5-Iodouridine as Novel Efficient Inhibitor of HIV-1
Pharmaceutics, 2023 Nucleoside reverse transcriptase inhibitors are the first class of drugs to be approved by the FDA for the suppression of HIV-1 and are widely used for this purpose in combination with drugs of other classes.
Ksenia Glumakova +10 more
doaj +1 more source
Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators
Gels, 2016 A new bolaamphiphile analog featuring carbamate moieties was synthesized in six steps starting from thymidine. The amphiphile structure exhibits nucleoside-sugar polar heads attached to a hydrophobic spacer via carbamate (urethane) functions.
Laurent Latxague +5 more
doaj +1 more source
Synthesis and anticancer evaluation of 4’-thio and 4’-sulfinyl pyrimidine nucleoside analogues [PDF]
, 2021 Analogues of the canonical nucleosides required for nucleic acid synthesis have a longstanding presence and proven capability within antiviral and anticancer research.
Mark , Smith +5 more
core +1 more source
Adenosine as a signaling molecule in the retina: biochemical and developmental aspects
Anais da Academia Brasileira de Ciências, 2002 The nucleoside adenosine plays an important role as a neurotransmitter or neuromodulator in the central nervous system, including the retina. In the present paper we review compelling evidence showing that adenosine is a signaling molecule in the ...
ROBERTO PAES-DE-CARVALHO
doaj +1 more source