Results 21 to 30 of about 149,829 (255)

Carbocyclic nucleosides [PDF]

Medicinal Research Reviews, 1986
n ...
Marquez, Victor E., Lim, Mu-Ill
openaire   +3 more sources

Nucleic Acid Based Fluorinated Derivatives: New Tools for Biomedical Applications

Applied Sciences, 2012
Nucleic acid-based fluorinated derivatives, e.g., nucleosides or oligonucleotides connected to highly fluorinated chains or labeled with one or more fluorine atoms, have been investigated recently due to their high potential for biomedical applications ...
Christel Dolain, Amit Patwa, Guilhem Godeau, Philippe Barthélémy   +3 more
doaj   +1 more source

Radiosensitizing Nucleosides [PDF]

JNCI Journal of the National Cancer Institute, 1996
Chemotherapeutic drugs that perturb nucleotide metabolism have the potential to produce substantial sensitization of tumor cells to radiation treatment. The process is called radiosensitization, and the agents that induce it are called radiosensitizers.
C J, McGinn, D S, Shewach, T S, Lawrence
openaire   +2 more sources

Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years

Molecules, 2017
Background: Poor pharmacokinetic profiles and resistance are the main two drawbacks from which currently used antiviral agents suffer, thus make them excellent targets for research, especially in the presence of viral pandemics such as HIV and hepatitis ...
Hanadi Sinokrot, Tasneem Smerat, Anas Najjar, Rafik Karaman   +3 more
doaj   +1 more source

In Silico Drug Design for Purinergic GPCRs: Overview on Molecular Dynamics Applied to Adenosine and P2Y Receptors

Biomolecules, 2020
Molecular modeling has contributed to drug discovery for purinergic GPCRs, including adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and homology modeling have proven to be useful in understanding and predicting structure ...
Veronica Salmaso, Kenneth A. Jacobson
doaj   +1 more source

Nucleoside Analog 2′,3′-Isopropylidene-5-Iodouridine as Novel Efficient Inhibitor of HIV-1

Pharmaceutics, 2023
Nucleoside reverse transcriptase inhibitors are the first class of drugs to be approved by the FDA for the suppression of HIV-1 and are widely used for this purpose in combination with drugs of other classes.
Ksenia Glumakova, Georgy Ivanov, Valeria Vedernikova, Lena Shyrokova, Timofey Lebedev, Andrei Stomakhin, Anastasia Zenchenko, Vladimir Oslovsky, Mikhail Drenichev, Vladimir Prassolov, Pavel Spirin   +10 more
doaj   +1 more source

Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators

Gels, 2016
A new bolaamphiphile analog featuring carbamate moieties was synthesized in six steps starting from thymidine. The amphiphile structure exhibits nucleoside-sugar polar heads attached to a hydrophobic spacer via carbamate (urethane) functions.
Laurent Latxague, Alexandra Gaubert, David Maleville, Julie Baillet, Michael A. Ramin, Philippe Barthélémy   +5 more
doaj   +1 more source

Adenosine as a signaling molecule in the retina: biochemical and developmental aspects

Anais da Academia Brasileira de Ciências, 2002
The nucleoside adenosine plays an important role as a neurotransmitter or neuromodulator in the central nervous system, including the retina. In the present paper we review compelling evidence showing that adenosine is a signaling molecule in the ...
ROBERTO PAES-DE-CARVALHO
doaj   +1 more source

Synthesis, antimicrobial evaluation, and integrated DFT, molecular docking, and dynamics simulation studies of the novel pentanoylated methyl α-D-mannopyranoside derivatives

Next Materials
Antimicrobial resistance (AMR) represents a major global health challenge, highlighting the need for new antimicrobial agents. Many antimicrobial drugs contain carbohydrate moieties. This study explores the successful synthesis of novel derivatives ( 2 -
Sarkar M.A. Kawsar, Niloy Bhattacharjee, Anis Ul Islam, Yuki Fujii, Yasuhiro Ozeki   +4 more
doaj   +1 more source

5-aza-2′,2′-Difluoro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer

Pharmaceuticals, 2017
Tumor suppressor genes can be silenced genetically as well as epigenetically. One approach to reversing epigenetic suppression of tumor suppressor genes is to inhibit DNA methyl transferase.
Richard Daifuku, Zhenbo Hu, Yogen Saunthararajah   +2 more
doaj   +1 more source