Results 21 to 30 of about 251,788 (307)

Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years

Molecules, 2017
Background: Poor pharmacokinetic profiles and resistance are the main two drawbacks from which currently used antiviral agents suffer, thus make them excellent targets for research, especially in the presence of viral pandemics such as HIV and hepatitis ...
Hanadi Sinokrot, Tasneem Smerat, Anas Najjar, Rafik Karaman   +3 more
doaj   +1 more source

Structure of the Ribosomal RNA Decoding Site Containing a Selenium-Modified Responsive Fluorescent Ribonucleoside Probe. [PDF]

, 2017
Comprehensive understanding of the structure-function relationship of RNA both in real time and at atomic level will have a profound impact in advancing our understanding of RNA functions in biology.
Boerneke, Mark A, Hermann, Thomas, Nuthanakanti, Ashok, Srivatsan, Seergazhi G   +3 more
core   +1 more source

Nucleoside Analog 2′,3′-Isopropylidene-5-Iodouridine as Novel Efficient Inhibitor of HIV-1

Pharmaceutics, 2023
Nucleoside reverse transcriptase inhibitors are the first class of drugs to be approved by the FDA for the suppression of HIV-1 and are widely used for this purpose in combination with drugs of other classes.
Ksenia Glumakova, Georgy Ivanov, Valeria Vedernikova, Lena Shyrokova, Timofey Lebedev, Andrei Stomakhin, Anastasia Zenchenko, Vladimir Oslovsky, Mikhail Drenichev, Vladimir Prassolov, Pavel Spirin   +10 more
doaj   +1 more source

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Akada, Allison, Almoguera, Andreetta, Arai, Arlt, Arteaga, Arumugam, Asano, Bachem, Baldwin, Banerjee, Bartsch, Bergers, Best, Bold, Bondar, Buck, Burris, Chakravarti, Chakravarti, Choi, Cunningham, Cunningham, Dancer, Dong, Duxbury, Duxbury, Duxbury, Duxbury, Engelman, Feldmann, Ferrero, Galmarini, Geyer, Giovannetti, Goan, Greer, Hagmann, Hahn, Henke, Hruban, Humeniuk, Ischenko, Ishikawa, Itoi, Jansen, Karapetis, Kindler, Kong, Koopman, Kulik, Lei, Lemoine, Liau, Liau, Longley, Mackey, Mackey, Mackey, Mahon, Mamaghani, Marechal, Marmor, Martin Clynes, Mata, Maxwell, Mendelsohn, Meropol, Miwa, Moertel, Molina-Arcas, Moore, Morgillo, Moriyama, Muerkoster, Muerkoster, Nakahira, Nakajima, Nakano, Naomi Walsh, Nishimura, Oguri, Okamoto, Okumura, Olive, O’Driscoll, Pao, Park, Park, Peters, Plunkett, Ray McDermott, Ritzel, Rizwan Sheikh, Robert O’Connor, Ruggeri, Safran, Saito, Sakamoto, Schuller, Sebastiani, Shah, Shi, Simon, Spratlin, Takao, Takebayashi, Treat, Tsukamoto, Tzeng, Vaishampayan, Van Cutsem, van der Wilt, Wang, Wang, Wang, Xiong, Yamasaki, Yokoi   +119 more
core   +1 more source

In Silico Drug Design for Purinergic GPCRs: Overview on Molecular Dynamics Applied to Adenosine and P2Y Receptors

Biomolecules, 2020
Molecular modeling has contributed to drug discovery for purinergic GPCRs, including adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and homology modeling have proven to be useful in understanding and predicting structure ...
Veronica Salmaso, Kenneth A. Jacobson
doaj   +1 more source

Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators

Gels, 2016
A new bolaamphiphile analog featuring carbamate moieties was synthesized in six steps starting from thymidine. The amphiphile structure exhibits nucleoside-sugar polar heads attached to a hydrophobic spacer via carbamate (urethane) functions.
Laurent Latxague, Alexandra Gaubert, David Maleville, Julie Baillet, Michael A. Ramin, Philippe Barthélémy   +5 more
doaj   +1 more source

Determination of total potentially available nucleosides in bovine milk [PDF]

, 2010
Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D., Indyk, Harvey E., Manley-Harris, Merilyn   +2 more
core   +2 more sources

Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Frontières [PDF]

, 2008
OBJECTIVES: To describe the use of second-line protease-inhibitor regimens in Médecins Sans Frontières HIV programmes, and determine switch rates, clinical outcomes, and factors associated with survival.
Alexandra Calmy, Boyd, Braitstein, Calmy, Calmy, Chaiwarith, Colebunders, Daniel O'Brien, Ferradini, Gallant, Galárraga, Ivers, Laurent, Ledergerber, Mar Pujades-Rodríguez, Mocroft, Nicastri, Orrell, Pierre Humblet, Renaud-Théry, Srasuebkul, Sungkanuparph, Vasan, Vekemans, Walmsley   +24 more
core   +2 more sources

Adenosine as a signaling molecule in the retina: biochemical and developmental aspects

Anais da Academia Brasileira de Ciências, 2002
The nucleoside adenosine plays an important role as a neurotransmitter or neuromodulator in the central nervous system, including the retina. In the present paper we review compelling evidence showing that adenosine is a signaling molecule in the ...
ROBERTO PAES-DE-CARVALHO
doaj   +1 more source

Biogenesis of mitochondrial porin [PDF]

, 1990
We review here the present knowledge about the pathway of import and assembly of porin into mitochondria and compare it to those of other mitochondrial proteins.
A. Grossmann, A. L. Horwich, B. L. Geller, B. Schmidt, C. Smagula, C. Witte, C. Zwizinski, C. Zwizinski, D. M. Kolansky, D. Roise, D. Vestweber, D. W. Nicholson, E. C. Hurt, E. C. Hurt, E. C. Hurt, E. C. Hurt, F.-U. Hartl, G. Hallermayer, G. Hawlitschek, G. Heijne von, G. S. Adrian, H. Aquila, H. Aquila, H. Freitag, H. Freitag, H. Freitag, H. Murakami, H. Ono, H. Wiech, J. A. Rothblatt, K. Mihara, K. Mihara, L. Chen, M. Colombini, M. Eilers, M. Eilers, M. G. Waters, M. Linden, M. Mueckler, M. P. Yaffe, M. Schleyer, M. Schleyer, M. Schwaiger, M. Y. Cheng, M. Yang, N. Pfanner, N. Pfanner, N. Pfanner, N. Pfanner, N. Pfanner, N. Pfanner, N. Pflanner, R. A. Pollock, R. A. Stuart, R. Benz, R. E. Jensen, R. J. Deshaies, R. Jaenicke, R. Kleene, R. Kleene, R. Pfaller, R. Pfaller, R. Pfaller, R. Pfaller, R. Zimmermann, S. Hamajima, S. M. Gasser, S. M. Gasser, T. Hase, T. Imanaka, U. I. Flügge, W. Hansen, W. J. Chirico, W. Neupert, W.-J. Chen   +74 more
core   +1 more source