Results 31 to 40 of about 173,532 (309)

General Principles for Yield Optimization of Nucleoside Phosphorylase-Catalyzed Transglycosylations [PDF]

, 2019
This is our publication "General Principles for Yield Optimization of Nucleoside Phosphorylase-Catalyzed Transglycosylations" that described the prediction and optimization of yields in nucleoside transglycosylations mediated by nucleoside phosphorylases.
Anke, Kurreck, Peter, Neubauer, Felix, Kaspar, Katja, Hellendahl, Robert T., Giessmann, Matthias, Gimpel   +5 more
core   +1 more source

5-aza-2′,2′-Difluoro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer

Pharmaceuticals, 2017
Tumor suppressor genes can be silenced genetically as well as epigenetically. One approach to reversing epigenetic suppression of tumor suppressor genes is to inhibit DNA methyl transferase.
Richard Daifuku, Zhenbo Hu, Yogen Saunthararajah   +2 more
doaj   +1 more source

Identification of a Biosynthetic Gene Cluster Responsible for the Production of a New Pyrrolopyrimidine Natural Product—Huimycin

Biomolecules, 2020
Pyrrolopyrimidines are an important class of natural products with a broad spectrum of biological activities, including antibacterial, antifungal, antiviral, anticancer or anti-inflammatory.
Hui Shuai, Maksym Myronovskyi, Suvd Nadmid, Andriy Luzhetskyy   +3 more
doaj   +1 more source

FTIR, 1H-/13C-NMR spectral characterization, antimicrobial, anticancer, antioxidant, anti-inflammatory, PASS, SAR, and in silico properties of methyl α-D-glucopyranoside derivatives

Chemical Physics Impact
A novel series of biologically active derivatives based on methyl α-D-glucopyranoside (MGP) has been developed, comprising 6-O-monosubstituted MGP derivatives obtained from methyl α-D-glucopyranoside.
Jannatul Ferdous, Faizan Abul Qais, Ferdausi Ali, Debashis Palit, Imtiaj Hasan, Sarkar M.A. Kawsar   +5 more
doaj   +1 more source

Synthesis and evaluation of purine C-nucleoside analogues as versatile tools for therapeutic applications [PDF]

, 2023
reservedGli oligonucleotidi sono emersi come validi strumenti diagnostici e terapeutici, come dimostra il numero crescente di farmaci a base di acidi nucleici approvati negli ultimi anni.
FALOCI, FEDERICO
core  

A comparison between abacavir and efavirenz as the third drug used in combination with a background therapy regimen of 2 nucleoside reverse-transcriptase inhibitors in patients with initially suppressed viral loads [PDF]

, 2006
Background. Our objective was to compare the rate of viral rebound and therapy failure in patients receiving abacavir or efavirenz as the third drug ( in addition to 2 non-abacavir nucleosides) in combination antiretroviral therapy ( cART) and to compare
Phillips, AN, L. Sighinolfi, D'ARMINIO MONFORTE A, R. Cauda, MOIOLI MC, Monforte, AD, COZZI-LEPRI A, DI GIAMBENEDETTO S, M. Mena, Sighinolfi, L, SIGHINOLFI L, A. Cozzi Lepri, Lichtner, M, ICoNA Study Group, Arlotti, M, M. Lichtner, Bongiovanni, M, Mena, M, M. Arlotti, UCSC Roma HIV Cohort Study Group, CAUDA R, A. N. Phillips, De Luca, A, Di Giambenedetto, S, Cozzi-Lepri, A, DE LUCA A, BONGIOVANNI M, PHILLIPS AN, UCSC-Roma HIV Cohort Study Grp, Narciso, P, Cauda, R, IMIT Study Grp, IMIT Study Group, A. De Luca, ICoNA Study Grp, MENA M, ARLOTTI M, NARCISO P, LICHTNER M, M. C. Moioli, Moioli, MC, S. Di Giambenedetto, P. Narciso, M. Bongiovanni, A. d’Arminio Monforte   +44 more
core   +1 more source

Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications [PDF]

, 2022
Biocatalytic nucleoside (trans-)glycosylations catalyzed by nucleoside phosphorylases have graduated to a practical and convenient approach to the preparation of modified nucleosides, which are important pharmaceuticals for the treatment of various ...
Anke, Kurreck, Christoph, Jacob, Sarah, Westarp, Peter, Neubauer, Felix, Brandt, Sebastian, Kemper, Felix, Kaspar, Lea, Eilert, Anett, Schallmey   +8 more
core   +1 more source

Chemical reactivity, molecular electrostatic potential, FTIR, NMR, in vitro, and in silico studies of mannopyranoside derivatives: 3-Nitrobenzoylation leads to improve antimicrobial activity

Chemical Physics Impact
This investigation Extensively explored the synthesis and potential therapeutic applications of derivatives derived from methyl α-d-mannopyranoside.
Shahin Sultana, Md. Ahad Hossain, Suvro Biswas, Md. Abu Saleh, Ferdausi Ali, Sarkar M.A. Kawsar   +5 more
doaj   +1 more source

The Interactions of Anti-HIV Pronucleotides with a Model Phospholipid Membrane

Molecules
Pronucleotides, after entering the cell, undergo chemical or enzymatic conversion into nucleotides with a free phosphate residue, and the released nucleoside 5′-monophosphate is then phosphorylated to the biologically active form, namely nucleoside 5 ...
Monika Rojewska, Joanna Romanowska, Adam Kraszewski, Michał Sobkowski, Krystyna Prochaska   +4 more
doaj   +1 more source

Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. [PDF]

, 2011
Adenosine is involved in several neurological and behavioral disorders including alcoholism. In cultured cell and animal studies, type 1 equilibrative nucleoside transporter (ENT1, slc29a1), which regulates adenosine levels, is known to regulate ethanol ...
Hyung Wook Nam, Karpyak Victor M., Preuss Ulrich W., Peter Zill, Colin Colby, David A. Mrazek, Colby Colin, Biernacka Joanna M., Moonnoh R. Lee, Preuss, Ulrich W., Victor M. Karpyak, Lee, Moonnoh R., Kim, Jeong-Hyun, Kim Jeong-Hyun, Lee Moonnoh R., Zill, Peter, Jeong-Hyun Kim, Joanna M. Biernacka, Nam Hyung Wook, David A Mrazek, Gihyun Yoon, Moonnoh R Lee, Ulrich W. Preuss, Zill Peter, Colby, Colin, Doo-Sup Choi, Yoon, Gihyun, Joanna M Biernacka, Ulrich W Preuss, Mrazek, David A., Nam, Hyung Wook, Yoon Gihyun, Choi, Doo-Sup, Victor M Karpyak, Mrazek David A., Biernacka, Joanna M., Choi Doo-Sup, Karpyak, Victor M.   +37 more
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