Results 1 to 10 of about 352,767 (265)
Molecules, 2022 Cancer is a multifactorial disorder caused by several aberrations in gene expression that generate a homeostatic imbalance between cell division and death [...]
Alessandra Ammazzalorso +1 more
openaire +3 more sources
American Journal of Clinical Pathology, 2003 The recent clinical and commercial success of anticancer antibodies such as rituximab and trastuzumab has created great interest in antibody-based therapeutics for hematopoietic malignant neoplasms and solid tumors. Given the likelihood of lower toxic effects of antibodies that target tumor cells and have limited impact on nonmalignant bystander organs
Jeffrey S, Ross +4 more
openaire +2 more sources
Novel Anticancer Strategies [PDF]
Pharmaceutics, 2021 Cancer incidence and mortality continue to increase rapidly worldwide [...]
openaire +3 more sources
Organometallic Anticancer Compounds
Journal of Medicinal Chemistry, 2010 The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still used in more than 50% of the treatment regimes for patients suffering from cancer, is highly needed.1,2 Despite their tremendous success, these platinum compounds suffer from two main disadvantages: they are inefficient against platinum-resistant tumors ...
Gasser, Gilles +2 more
openaire +3 more sources
Anticancer Platelet‐Mimicking Nanovehicles [PDF]
Advanced Materials, 2015 A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. This PM-coated nanovehicle can also effectively eliminate the circulating tumor cells in vivo and inhibit ...
Quanyin, Hu +5 more
openaire +2 more sources
Supramolecular Photoactivatable Anticancer Hydrogels [PDF]
Journal of the American Chemical Society, 2017 A photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has been incorporated into G-quadruplex G4K+ borate hydrogels by using borate ester linkages (Pt-G4K+B hydrogel). These were characterized by 11B NMR, attenuated total reflection Fourier transform infrared spectroscopy, circular dichroism, scanning electron microscopy and ...
V. Venkatesh +8 more
openaire +2 more sources
Anticancer Drug Discovery [PDF]
JNCI Journal of the National Cancer Institute, 1991 The National Cancer Institute's (NCI's) human tumor cell line panel for screening potential new anticancer drugs is now operational (/). Its implementation and the demonstration of its feasibility represent a technical and organizational tour de force.
openaire +2 more sources
Anticancer vaccination strategies
Annals of Oncology, 2004 Tumors often upregulate the expression of molecules that are normally suppressed or expressed at much lower levels in adult tissues, the so-named tumor-associated antigens (TAAs) [1]. Some ‘self-reactive’ T lymphocytes capable of T-cell receptor (TCR)-mediated recognition of these antigens and of mediating tumor rejection survive thymic selection and ...
NENCIONI, ALESSIO +3 more
openaire +2 more sources
Apoptins: selective anticancer agents
Trends in Molecular Medicine, 2014 Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have ...
Rollano Penaloza, Oscar M. +9 more
openaire +3 more sources
Anticancer Mechanisms of Cannabinoids
Current Oncology, 2016 In addition to the well-known palliative effects of cannabinoids on some cancer-associated symptoms, a large body of evidence shows that these molecules can decrease tumour growth in animal models of cancer. They do so by modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival. In addition, cannabinoids
Velasco, G., Sánchez, C., Guzmán, M.
openaire +3 more sources