Results 41 to 50 of about 352,767 (265)

Organ-preserving embolization of a giant splenic hemangioma in an adult

CVIR Endovascular
Splenic hemangioma is a rare benign tumor, often found incidentally. Large hemangiomas bear a high risk of spontaneous rupture, an acute condition often life-threatening that requires immediate intervention.
Manos Siderakis, Stamatia Dodoura, George Gkeneralis, Viktoria Kartsouni, Myrsini Gkeli   +4 more
doaj   +1 more source

New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006

Marine Drugs, 2016
Salterns, one of the most extreme natural hypersaline environments, are a rich source of halophilic and halotolerant microorganisms, but they remain largely underexplored ecological niches in the discovery of bioactive secondary metabolites. In continued
Sangkeun Son, Sung-Kyun Ko, Mina Jang, Jong Won Kim, Gil Soo Kim, Jae Kyoung Lee, Eun Soo Jeon, Yushi Futamura, In-Ja Ryoo, Jung-Sook Lee, Hyuncheol Oh, Young-Soo Hong, Bo Yeon Kim, Shunji Takahashi, Hiroyuki Osada, Jae-Hyuk Jang, Jong Seog Ahn   +16 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases

Frontiers in Immunology, 2022
Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune ...
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes

European Journal of Medicinal Chemistry Reports
Mitotic kinesin-like protein 2 (MKLP2/KIF20A) is a key mitotic regulator frequently overexpressed in human malignancies and its abundance is positively correlated with poor outcomes of the disease.
Jian Huang, Ting Zhang, Julia Kalashova, Jinhua Li, Chenglu Yang, Linsheng Zhong, Xiaohu Zhou, Qiong Shi, Gang Lv, Jiadai Chenyu, Yidan Xia Abuliezi, Duo Yu, Xuejiao Jiang, Mallu Chenna Reddy, Namrta Choudhry, Naganna Nimishetti, Dun Yang   +16 more
doaj   +1 more source

Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells

Frontiers in Cell and Developmental Biology, 2020
Colon cancer is one of the leading causes of cancer-related death in the world. The development of new drugs and therapeutic strategies for patients with colon cancer are urgently needed.
Lin Hong, Lin Hong, Jundixia Chen, Fang Wu, Fengjiao Wu, Xin Shen, Peisen Zheng, Rongrong Shao, Kongqin Lu, Zhiguo Liu, Daoxing Chen, Guang Liang, Yuepiao Cai, Peng Zou, Peng Zou, Peng Zou, Yiqun Xia   +16 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

TLR4-dependent effects of ISAg treatment on conventional T cell polarization in vivo

Animal Cells and Systems, 2019
We recently demonstrated that the polysaccharide component of the Korean medicinal herb Angelica gigas (immuno-stimulatory fraction of A. gigas; ISAg) induces anticancer effects in mice by activating natural killer (NK) and natural killer T (NKT) cells ...
Sung Won Lee, Hyun Jung Park, Seo Hyun Kim, Sooyong Shin, Kyung Hee Kim, Sang Jae Park, Seokmann Hong, Sung Ho Jeon   +7 more
doaj   +1 more source

In vitro osteoblastic differentiation of mesenchymal stem cells generates cell layers with distinct properties

Stem Cell Research & Therapy, 2018
Background Differentiation of mesenchymal stem cells to osteoblasts is widely performed in research laboratories. Classical tests to prove this differentiation employ procedures such as cell fixation, cell lysis or cell scraping.
Hanna Hanna, Lluis M. Mir, Franck M. Andre   +2 more
doaj   +1 more source