Results 41 to 50 of about 360,716 (266)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

TLR4-dependent effects of ISAg treatment on conventional T cell polarization in vivo

Animal Cells and Systems, 2019
We recently demonstrated that the polysaccharide component of the Korean medicinal herb Angelica gigas (immuno-stimulatory fraction of A. gigas; ISAg) induces anticancer effects in mice by activating natural killer (NK) and natural killer T (NKT) cells ...
Sung Won Lee, Hyun Jung Park, Seo Hyun Kim, Sooyong Shin, Kyung Hee Kim, Sang Jae Park, Seokmann Hong, Sung Ho Jeon   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes

European Journal of Medicinal Chemistry Reports
Mitotic kinesin-like protein 2 (MKLP2/KIF20A) is a key mitotic regulator frequently overexpressed in human malignancies and its abundance is positively correlated with poor outcomes of the disease.
Jian Huang, Ting Zhang, Julia Kalashova, Jinhua Li, Chenglu Yang, Linsheng Zhong, Xiaohu Zhou, Qiong Shi, Gang Lv, Jiadai Chenyu, Yidan Xia Abuliezi, Duo Yu, Xuejiao Jiang, Mallu Chenna Reddy, Namrta Choudhry, Naganna Nimishetti, Dun Yang   +16 more
doaj   +1 more source

In vitro osteoblastic differentiation of mesenchymal stem cells generates cell layers with distinct properties

Stem Cell Research & Therapy, 2018
Background Differentiation of mesenchymal stem cells to osteoblasts is widely performed in research laboratories. Classical tests to prove this differentiation employ procedures such as cell fixation, cell lysis or cell scraping.
Hanna Hanna, Lluis M. Mir, Franck M. Andre   +2 more
doaj   +1 more source

Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases

Frontiers in Immunology, 2022
Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune ...
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine

Molecular Therapy: Nucleic Acids, 2017
Pediatric cancers differ from adult tumors, especially by their very low mutational rate. Therefore, their etiology could be explained in part by other oncogenic mechanisms such as chromosomal rearrangements, supporting the possible implication of fusion
Célia Dupain, Anne Catherine Harttrampf, Giorgia Urbinati, Birgit Geoerger, Liliane Massaad-Massade   +4 more
doaj   +1 more source

Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells

Frontiers in Cell and Developmental Biology, 2020
Colon cancer is one of the leading causes of cancer-related death in the world. The development of new drugs and therapeutic strategies for patients with colon cancer are urgently needed.
Lin Hong, Lin Hong, Jundixia Chen, Fang Wu, Fengjiao Wu, Xin Shen, Peisen Zheng, Rongrong Shao, Kongqin Lu, Zhiguo Liu, Daoxing Chen, Guang Liang, Yuepiao Cai, Peng Zou, Peng Zou, Peng Zou, Yiqun Xia   +16 more
doaj   +1 more source

Anticancer Activity in Planctomycetes [PDF]

Frontiers in Marine Science, 2019
There is a strong need to develop new drugs against many severe diseases. Therapy resistance is a major problem, for instance, in infectious diseases and cancer. Drug discovery has again turned to nature to search for molecules that can become drug leads.
Rita Calisto, Rita Calisto, Eirik Færøy Sæbø, Julia E. Storesund, Lise Øvreås, Lise Øvreås, Lars Herfindal, Olga M. Lage, Olga M. Lage   +8 more
openaire   +4 more sources