Results 1 to 10 of about 132,388 (166)
In vitro Differentiation of Thymic Treg Cell Progenitors to Mature Thymic Treg Cells [PDF]
BIO-PROTOCOL, 2019 Thymic Treg cell differentiation occurs via a two-step process. Step one generates Treg cell progenitors (TregP) and is driven by strong TCR interactions with antigens presented in the thymus. Step two is initiated by activation of STAT5 via IL-2, or IL-15, leading to mature Treg cells capable of emigrating from the thymus and mediating immune ...
David Owen, Michael Farrar
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Turning the Tide Against Regulatory T Cells
Frontiers in Oncology, 2019 Regulatory T (Treg) cells play crucial roles in health and disease through their immunosuppressive properties against various immune cells. In this review we will focus on the inhibitory role of Treg cells in anti-tumor immunity.
SeongJun Han +7 more
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Treg cells to the rescue [PDF]
Arthritis & Rheumatism, 2012 In this issue of Arthritis & Rheumatism, Kong and colleagues report that collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA), can be effectively treated by systemic injection of Treg cells (1). These results raise several questions: Are there defects in Treg cell numbers or function in RA?
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Cell Reports, 2020 Summary: Regulatory T (Treg) cells integrate diverse environmental signals to modulate their function for optimal suppression. Translational regulation represents a favorable mechanism for Treg cell environmental sensing and adaptation. In this study, we
Yujian H. Yang +9 more
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Frontiers in Immunology, 2021 FOXP3+ regulatory T cells (Treg cells) are a specialized population of CD4+ T cells that restrict immune activation and are essential to prevent systemic autoimmunity.
Justin Jacobse +11 more
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Journal of Immunology Research, 2014 Regulatory T (Treg) cells are potent suppressors that maintain immune homeostasis. Accumulation of Treg can inhibit effective immune responses in cancer patients, leading to tumor development and progression.
Jie-Yao Li +12 more
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iScience, 2022 Summary: Overwhelming evidence indicates that infiltration of tumors by Treg cells with elevated levels of FOXP3 suppresses the host antitumor immune response. However, the molecular mechanisms that maintain high expression of FOXP3 in tumor-infiltrating
Junqing An +7 more
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Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells. [PDF]
PLoS ONE, 2016 BACKGROUND:HIV-1 has proved to infect regulatory T cells (Treg) modifying their phenotype and impairing their suppressive capacity. As Treg cells are a crucial component in the preservation of the immune homeostasis, we researched that the antiviral ...
Didiana Jaramillo-Ruiz +4 more
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Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis
Frontiers in Immunology, 2022 ObjectivesThis study aimed to investigate the changes in quantity and function of T helper (Th)-like T regulatory (Treg) cell subsets in peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients and to understand their ...
Rui Zhang +9 more
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The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients
Journal of Immunology Research, 2018 Background. Treg cells play an important role in the pathogenic progress of asthma. Objective. To address the alterations of Treg cells in asthma. Methods.
Tiantian Chen +6 more
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