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Untangling the Knots of Regulatory T Cell Therapy in Solid Organ Transplantation
Frontiers in Immunology, 2022 Numerous preclinical studies have provided solid evidence supporting adoptive transfer of regulatory T cells (Tregs) to induce organ tolerance. As a result, there are 7 currently active Treg cell-based clinical trials in solid organ transplantation ...
Gabriel Orozco +8 more
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Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus [PDF]
Brazilian Journal of Medical and Biological Research, 2014 Regulatory T (TREG) cells play an important role in maintaining immune tolerance and avoiding autoimmunity. We analyzed the expression of membrane molecules in TREG and effector T cells in systemic lupus erythematosus (SLE).
D. Mesquita Júnior +5 more
doaj +3 more sources
Frontiers in Immunology, 2022 Regulatory T cells (Treg) play pivotal roles in maintaining self-tolerance and preventing immunological diseases such as allergy and autoimmunity through their immunosuppressive properties.
Hyun Jung Park +5 more
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Scientific Reports, 2022 The CD4+ regulatory T (Treg) cell lineage, defined by FOXP3 expression, comprises thymus-derived (t)Treg cells and peripherally induced (p)Treg cells. As a model for Treg cells, studies employ TGF-β-induced (i)Treg cells generated from CD4+ conventional ...
Mark Mensink +5 more
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The Fate of Human Treg Cells [PDF]
Immunity, 2009 In this issue of Immunity, Miyara et al. (2009) demonstrate that FoxP3(+) cells in human peripheral blood are heterogeneous in function, and CD45RA expression defines their different stages of differentiation.
BATTAGLIA, MARCO MARIA +1 more
openaire +3 more sources
Autocrine TGF-β1 Maintains the Stability of Foxp3+ Regulatory T Cells via IL-12Rβ2 Downregulation
Biomolecules, 2020 Transforming growth factor beta 1 (TGF-β1) is an immunosuppresive cytokine that plays an essential role in immune homeostasis. It is well known that regulatory T (Treg) cells express TGF-β1; however, the role of autocrine TGF-β1 in the development ...
Garam Choi +4 more
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Frontiers in Immunology, 2023 Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in the research of tumor progression. Treg cells have the function of inhibiting the immune effector cells, preventing tissue damage, and suppressing inflammation ...
Xinyan Wu +10 more
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Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. [PDF]
PLoS ONE, 2012 BACKGROUND: Regulatory T (Treg) cells play an important role in the maintenance of immune system homeostasis. Multiple myeloma (MM) is a plasma cell disorder frequently associated with impaired immune cell numbers and functions. METHODS: We analyzed Treg
Karthick Raja Muthu Raja +5 more
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In vitro Differentiation of Thymic Treg Cell Progenitors to Mature Thymic Treg Cells [PDF]
BIO-PROTOCOL, 2019 Thymic Treg cell differentiation occurs via a two-step process. Step one generates Treg cell progenitors (TregP) and is driven by strong TCR interactions with antigens presented in the thymus. Step two is initiated by activation of STAT5 via IL-2, or IL-15, leading to mature Treg cells capable of emigrating from the thymus and mediating immune ...
David Owen, Michael Farrar
openaire +3 more sources
Turning the Tide Against Regulatory T Cells
Frontiers in Oncology, 2019 Regulatory T (Treg) cells play crucial roles in health and disease through their immunosuppressive properties against various immune cells. In this review we will focus on the inhibitory role of Treg cells in anti-tumor immunity.
SeongJun Han +7 more
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