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Frontiers in Immunology, 2023 Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in the research of tumor progression. Treg cells have the function of inhibiting the immune effector cells, preventing tissue damage, and suppressing inflammation ...
Xinyan Wu +10 more
doaj +2 more sources
Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond
Trends in Immunology, 2023 Regulatory T (Treg) cells ensure tolerance against self-antigens, limit excessive inflammation, and support tissue repair processes. Therefore, Treg cells are currently attractive candidates for the treatment of certain inflammatory diseases, autoimmune ...
Markus Feuerer
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Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
Cell, 2021 Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how their immune-suppressive function is regulated in the tumor microenvironment (TME) remains unknown.
Francesco Marangoni +2 more
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The role of Treg cells in colorectal cancer and the immunotherapy targeting Treg cells. [PDF]
Front ImmunolColorectal cancer (CRC) is among the most prevalent and lethal cancers globally, accounting for approximately 10% of all cancer cases and deaths. Regulatory T (Treg) cells, which accumulate in CRC tissue, suppress anti-tumor immune responses and facilitate tumor progression.
Yu H, Yang R, Li M, Li D, Xu Y.
europepmc +4 more sources
Cell Reports, 2021 SUMMARY Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in lymphoid organs express the putative checkpoint molecule
Hridesh Banerjee +2 more
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Targeting Treg cells in cancer immunotherapy [PDF]
European Journal of Immunology, 2019 AbstractFoxp3‐expressing regulatory T (Treg) cells, which are indispensable for preventing autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into tumor tissues, which is often associated with poor prognosis in cancer patients.
Atsushi Tanaka, Shimon Sakaguchi
openaire +3 more sources
Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?
Cancer Science, 2019 Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self‐ and nonself‐antigens to maintain immune homeostasis. In tumor immunity, Treg cells are involved in tumor development and progression by inhibiting antitumor immunity.
Yoshihiro Ohue, Hiroyoshi Nishikawa
exaly +2 more sources
Immunology, 2021 CD4+ regulatory T (Treg) cells, dependent upon the transcription factor Foxp3, contribute to tumour immunosuppression but are also required for immune homeostasis.
Sarah K Whiteside +2 more
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Immunity, 2020 Summary Specialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg cells exist and how they differentiate remain elusive.
Michael Delacher +2 more
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Immunity, 2019 Regulatory T (Treg) cells are crucial for immune homeostasis, but they also contribute to tumor immune evasion by promoting a suppressive tumor microenvironment (TME).
Maria Chikina +2 more
exaly +2 more sources