Results 31 to 40 of about 132,388 (166)

Eos, Goddess of Treg Cell Reprogramming [PDF]

Immunity, 2013
Under certain conditions, Sharma et al. (2013) show in this issue of Immunity that a subpopulation of Foxp3+ regulatory T cells loses expression of the transcription factor Eos and develops into Foxp3+ T helper cells that facilitate priming of naive CD8+ T cells.
Rieder, Sadiye Amcaoglu, Shevach, Ethan M.   +1 more
openaire   +2 more sources

In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy. [PDF]

PLoS ONE, 2010
BACKGROUND: Migration of T cells, including regulatory T (Treg) cells, into the secondary lymph organs is critically controlled by chemokines and adhesion molecules.
Naozumi Ishimaru, Takeshi Nitta, Rieko Arakaki, Akiko Yamada, Martin Lipp, Yousuke Takahama, Yoshio Hayashi   +6 more
doaj   +1 more source

Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity

Frontiers in Immunology, 2018
While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, the regulatory response mediated by Treg cells upon infection by ...
Cintia L. Araujo Furlan, Cintia L. Araujo Furlan, Jimena Tosello Boari, Jimena Tosello Boari, Constanza Rodriguez, Constanza Rodriguez, Fernando P. Canale, Fernando P. Canale, Facundo Fiocca Vernengo, Facundo Fiocca Vernengo, Santiago Boccardo, Santiago Boccardo, Cristian G. Beccaria, Cristian G. Beccaria, Véronique Adoue, Véronique Adoue, Véronique Adoue, Olivier Joffre, Olivier Joffre, Olivier Joffre, Adriana Gruppi, Adriana Gruppi, Carolina L. Montes, Carolina L. Montes, Eva V. Acosta Rodriguez, Eva V. Acosta Rodriguez   +25 more
doaj   +1 more source

Arming Treg Cells at the Inflammatory Site [PDF]

Immunity, 2009
In this issue of Immunity, Zhang et al. (2009) propose that Treg cells, in order to efficiently control alloimmune response, need to be educated first in the target tissue before entering the draining lymph node.
Belkaid, Yasmine, V. Tarbell, Kristin
openaire   +2 more sources

Foxp3 Post-translational Modifications and Treg Suppressive Activity

Frontiers in Immunology, 2019
Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which can suppress the immune response via multiple distinct mechanisms.
Guoping Deng, Xiaomin Song, Shigeyoshi Fujimoto, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo, Yasuhiro Nagai, Mark I. Greene   +6 more
doaj   +1 more source

Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment. [PDF]

PLoS ONE, 2012
BACKGROUND: Multiple myeloma (MM) is a plasma cell malignancy frequently associated with impaired immune cell numbers and functions. In MM, several studies have previously shown that CD4 regulatory T (Treg) cells hamper effector T cell functions and ...
Karthick Raja Muthu Raja, Lenka Kubiczkova, Lucie Rihova, Martin Piskacek, Pavla Vsianska, Renata Hezova, Ludek Pour, Roman Hajek   +7 more
doaj   +1 more source

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

eLife
FOXP3+ regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states.
Valentina Stolz, Rafael de Freitas e Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier   +23 more
doaj   +1 more source

The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells

Cell Reports, 2019
Summary: Forkhead box protein P3+ (FOXP3+) regulatory T cells (Treg cells) play a key role in maintaining tolerance and immune homeostasis. Here, we report that a T cell-specific deletion of the transcription factor MAZR (also known as PATZ1) leads to an
Liisa Andersen, Alexandra Franziska Gülich, Marlis Alteneder, Teresa Preglej, Maria Jonah Orola, Narendra Dhele, Valentina Stolz, Alexandra Schebesta, Patricia Hamminger, Anastasiya Hladik, Stefan Floess, Thomas Krausgruber, Thomas Faux, Syed Bilal Ahmad Andrabi, Jochen Huehn, Sylvia Knapp, Tim Sparwasser, Christoph Bock, Asta Laiho, Laura L. Elo, Omid Rasool, Riitta Lahesmaa, Shinya Sakaguchi, Wilfried Ellmeier   +23 more
doaj   +1 more source

Adoptive Transfer of Treg Cells Combined with Mesenchymal Stem Cells Facilitates Repopulation of Endogenous Treg Cells in a Murine Acute GVHD Model. [PDF]

PLoS ONE, 2015
Therapeutic effects of combined cell therapy with mesenchymal stem cells (MSCs) and regulatory T cells (Treg cells) have recently been studied in acute graft-versus-host-disease (aGVHD) models.
Eun-Sol Lee, Jung-Yeon Lim, Keon-Il Im, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho   +6 more
doaj   +1 more source

Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase.

PLoS ONE, 2013
Although the cell-to-cell contact between CD4(+)Foxp3(+) regulatory T (Treg) and their target cells is important for the suppressor function of Treg cells, the regulation of this process is not well understood.
Takashi Tomiyama, Yoshihiro Ueda, Tomoya Katakai, Naoyuki Kondo, Kazuichi Okazaki, Tatsuo Kinashi   +5 more
doaj   +1 more source