Results 41 to 50 of about 4,874,341 (306)

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

Cell Reports, 2017
Summary: Foxp3+ regulatory T (Treg) cells, which suppress immune responses, are highly proliferative in vivo. However, it remains unclear how the active replication of Treg cells is maintained in vivo. Here, we show that branched-chain amino acids (BCAAs)
Kayo Ikeda, Makoto Kinoshita, Hisako Kayama, Shushi Nagamori, Pornparn Kongpracha, Eiji Umemoto, Ryu Okumura, Takashi Kurakawa, Mari Murakami, Norihisa Mikami, Yasunori Shintani, Satoko Ueno, Ayatoshi Andou, Morihiro Ito, Hideki Tsumura, Koji Yasutomo, Keiichi Ozono, Seiji Takashima, Shimon Sakaguchi, Yoshikatsu Kanai, Kiyoshi Takeda   +20 more
doaj   +1 more source

In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy. [PDF]

PLoS ONE, 2010
BACKGROUND: Migration of T cells, including regulatory T (Treg) cells, into the secondary lymph organs is critically controlled by chemokines and adhesion molecules.
Naozumi Ishimaru, Takeshi Nitta, Rieko Arakaki, Akiko Yamada, Martin Lipp, Yousuke Takahama, Yoshio Hayashi   +6 more
doaj   +1 more source

‘Repair’ Treg Cells in Tissue Injury [PDF]

Cellular Physiology and Biochemistry, 2017
Studies in mice and humans have elucidated an important role for Tregs in promoting tissue repair and restoring tissue integrity. Emerging evidence has revealed that Tregs promoted wound healing and repair processes at multiple tissue sites, such as the heart, liver, kidney, muscle, lung, bone and central nervous system.
Chaoqi Zhang, Lifeng Li, Kexin Feng, Daoyang Fan, Wenhua Xue, Jingli Lu   +5 more
openaire   +3 more sources

Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity

Frontiers in Immunology, 2018
While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, the regulatory response mediated by Treg cells upon infection by ...
Cintia L. Araujo Furlan, Cintia L. Araujo Furlan, Jimena Tosello Boari, Jimena Tosello Boari, Constanza Rodriguez, Constanza Rodriguez, Fernando P. Canale, Fernando P. Canale, Facundo Fiocca Vernengo, Facundo Fiocca Vernengo, Santiago Boccardo, Santiago Boccardo, Cristian G. Beccaria, Cristian G. Beccaria, Véronique Adoue, Véronique Adoue, Véronique Adoue, Olivier Joffre, Olivier Joffre, Olivier Joffre, Adriana Gruppi, Adriana Gruppi, Carolina L. Montes, Carolina L. Montes, Eva V. Acosta Rodriguez, Eva V. Acosta Rodriguez   +25 more
doaj   +1 more source

Foxp3 Post-translational Modifications and Treg Suppressive Activity

Frontiers in Immunology, 2019
Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which can suppress the immune response via multiple distinct mechanisms.
Guoping Deng, Xiaomin Song, Shigeyoshi Fujimoto, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo, Yasuhiro Nagai, Mark I. Greene   +6 more
doaj   +1 more source

Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment. [PDF]

PLoS ONE, 2012
BACKGROUND: Multiple myeloma (MM) is a plasma cell malignancy frequently associated with impaired immune cell numbers and functions. In MM, several studies have previously shown that CD4 regulatory T (Treg) cells hamper effector T cell functions and ...
Karthick Raja Muthu Raja, Lenka Kubiczkova, Lucie Rihova, Martin Piskacek, Pavla Vsianska, Renata Hezova, Ludek Pour, Roman Hajek   +7 more
doaj   +1 more source

Eos, Goddess of Treg Cell Reprogramming [PDF]

Immunity, 2013
Under certain conditions, Sharma et al. (2013) show in this issue of Immunity that a subpopulation of Foxp3+ regulatory T cells loses expression of the transcription factor Eos and develops into Foxp3+ T helper cells that facilitate priming of naive CD8+ T cells.
Rieder, Sadiye Amcaoglu, Shevach, Ethan M.   +1 more
openaire   +2 more sources

Role and specificity of regulatory T cells during retroviral infection [PDF]

, 2009
During chronic viral infection of the hematopoietic system, both virus-mediated and immune-mediated effects may cause bone marrow dysfunction leading to cytopenias. To study the pathological consequences of the T helper response to unresolving chronic
Antunes, I.L., Antunes, I L
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

eLife
FOXP3+ regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states.
Valentina Stolz, Rafael de Freitas e Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier   +23 more
doaj   +1 more source