Results 41 to 50 of about 12,132,339 (300)
Treg Cells Protect Dopaminergic Neurons against MPP+ Neurotoxicity via CD47-SIRPA Interaction
Cellular Physiology and Biochemistry, 2017 Background/Aims: Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in ...
Yan Huang +4 more
doaj +1 more source
Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis
Frontiers in Immunology, 2022 ObjectivesThis study aimed to investigate the changes in quantity and function of T helper (Th)-like T regulatory (Treg) cell subsets in peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients and to understand their ...
Rui Zhang +9 more
doaj +1 more source
Journal of Experimental Medicine, 2011 HIF1α induction by mTOR represents a metabolic checkpoint for the differentiation of TH17 and Treg cells.
L. Shi +6 more
semanticscholar +1 more source
Cell Transplantation, 2020 Regulatory T (Treg) cells have anti-inflammatory functions and heighten immune tolerance. The proportion and functions of Treg cells are perturbed in rheumatoid arthritis (RA), contributing to the excessive immune activation associated with this disease.
Shutong Li +3 more
doaj +1 more source
‘Repair’ Treg Cells in Tissue Injury [PDF]
Cellular Physiology and Biochemistry, 2017 Studies in mice and humans have elucidated an important role for Tregs in promoting tissue repair and restoring tissue integrity. Emerging evidence has revealed that Tregs promoted wound healing and repair processes at multiple tissue sites, such as the heart, liver, kidney, muscle, lung, bone and central nervous system.
Chaoqi Zhang +5 more
openaire +3 more sources
PM2.5 disturbs the balance of Th17/Treg cells by targeting Got1 and HIF-1α in an asthma model.
Journal of Allergy and Clinical Immunology, 2020 BACKGROUND Epidemiologic evidence suggests that exposure to particulate matter ≤2.5 μm (PM2.5) aggravates asthma. OBJECTIVE Investigate the underlying mechanisms between PM2.5 exposure and asthma severity.
Licheng Sun +17 more
semanticscholar +1 more source
Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells
Cell Reports, 2017 Summary: Foxp3+ regulatory T (Treg) cells, which suppress immune responses, are highly proliferative in vivo. However, it remains unclear how the active replication of Treg cells is maintained in vivo. Here, we show that branched-chain amino acids (BCAAs)
Kayo Ikeda +20 more
doaj +1 more source
Treg cell abnormality and its potential treatments in patients with primary immune thrombocytopenia
Clinical and Translational Discovery, 2022 Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder. T regulatory cells (Treg), play an important role in the pathogenesis of the disease. Numerical and functional disorders of Treg cells were both demonstrated in ITP. Thymocyte
Lili Ji, Yunfeng Cheng
doaj +1 more source
Eos, Goddess of Treg Cell Reprogramming [PDF]
Immunity, 2013 Under certain conditions, Sharma et al. (2013) show in this issue of Immunity that a subpopulation of Foxp3+ regulatory T cells loses expression of the transcription factor Eos and develops into Foxp3+ T helper cells that facilitate priming of naive CD8+ T cells.
Rieder, Sadiye Amcaoglu +1 more
openaire +2 more sources
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
Nature Immunology, 2019 Regulatory T cells (Treg cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. Treg cells subvert beneficial anti-tumor immunity by modulating inhibitory receptor expression on tumor-infiltrating lymphocytes (TILs)
Deepali V. Sawant +18 more
semanticscholar +1 more source