Results 41 to 50 of about 132,388 (166)

Islet cell transplant and the incorporation of Tregs [PDF]

Current Opinion in Organ Transplantation, 2014
T regulatory cells (Tregs) play a central role in maintaining immune homeostasis and peripheral tolerance to foreign antigens in humans. The immune response to alloantigens and recurrence of autoimmunity contribute to pancreatic islet transplant dysfunction, hence the adoptive transfer of Tregs has the potential to significantly improve islet graft ...
Adam, Krzystyniak, Karolina, Gołąb, Piotr, Witkowski, Piotr, Trzonkowski   +3 more
openaire   +2 more sources

Differential regulation of Treg stability in human naïve and effector Treg subsets by TGFβ-signaling via ARKADIA-SKI axis

Frontiers in Immunology
IntroductionThe human FOXP3+ regulatory T (Treg) cells, a subset of CD4+ T cells with immunosuppressive function, are essential for the maintenance of immune homeostasis and tolerance.
Fan Yang, Alexis Yanes, Miao Li, Patrick Heizer, Ivan Linatoc, Michael E. Stephens, Yang Song, Tatiana Ort, Kyle J. Bednar, Yasuhiro Ikeda, Zengli Guo   +10 more
doaj   +1 more source

Lymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma

OncoImmunology
Regulatory T (Treg) cells are critical in shaping an immunosuppressive microenvironment to favor tumor progression and resistance to therapies. However, the heterogeneity and function of Treg cells in esophageal squamous cell carcinoma (ESCC) remain ...
Min Ma, Liang Li, Shu-Han Yang, Chuan Huang, Weitao Zhuang, Shujie Huang, Xin Xia, Yong Tang, Zijun Li, Zhi-Bin Zhao, Qingyun Chen, Guibin Qiao, Zhe-Xiong Lian   +12 more
doaj   +1 more source

Utilizing Regulatory T Cells Against Rheumatoid Arthritis

Frontiers in Oncology, 2014
Regulatory T (Treg) cells are essential for normal immune surveillance systems, and their dysfunction leads to development of diseases, such as autoimmune disorders.
Mohammad eHaque, Kristin eFino, Fengyang eLei, Xiaofang eXiong, Jianxun eSong   +4 more
doaj   +1 more source

Regulatory T cells induced by B cells suppress NLRP3 inflammasome activation and alleviate monosodium urate-induced gouty inflammation

iScience, 2021
Summary: Regulatory T cells induced by B cells (Treg-of-B cells), a distinct Foxp3- Treg cell subset, have established the roles in the suppression of inflammatory conditions, including asthma and intestinal inflammation.
Jing-Hui Huang, Bor-Luen Chiang
doaj   +1 more source

Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function

Journal for ImmunoTherapy of Cancer, 2019
Background Regulatory T (Treg) cells have an immunosuppressive function in cancer, but the underlying mechanism of immunosuppression in the tumor microenvironment (TME) is unclear.
Hye Ryun Kim, Hyo Jin Park, Jimin Son, Jin Gu Lee, Kyung Young Chung, Nam Hoon Cho, Hyo Sup Shim, Seyeon Park, Gamin Kim, Hong In Yoon, Hyun Gyung Kim, Yong Woo Jung, Byoung Chul Cho, Seong Yong Park, Sun Young Rha, Sang-Jun Ha   +15 more
doaj   +1 more source

Quantification of regulatory T cells in septic patients by real-time PCR-based methylation assay and flow cytometry. [PDF]

PLoS ONE, 2012
During sepsis, a relative increase of regulatory T (Treg) cells has been reported. Its persistence is associated with lymphocyte anergy, immunoparalysis and a poor prognosis.
Roman Tatura, Michael Zeschnigk, Michael Adamzik, Michael Probst-Kepper, Jan Buer, Jan Kehrmann   +5 more
doaj   +1 more source

Isolation Of Treg Cells And Treg Cell Suppression/Death Assay

, 2015
In vitro Treg suppression assays are performed to determine the functional effect of Treg cells on CD4 T cells. They are performed by co-culturing the responding population (Tresp) with the Treg cells or control CD4 cells (Tcon cells).
openaire   +1 more source

Throwing Treg cells off balance [PDF]

Nature Reviews Cancer, 2019
Di Pilato et al. selectively modulated the function of regulatory T (Treg) cells in tumours by targeting the CARMA1–BCL10–MALT1 (CBM) signalosome complex in only a fraction of Treg cells and showed that this was sufficient to impede tumour growth and prime the tumour microenvironment for immune checkpoint blockade.
openaire   +2 more sources

Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function

Frontiers in Immunology, 2020
Regulatory T cells (Treg cells) are essential for maintaining immune tolerance, and the dysfunction of Treg cells may cause autoimmune diseases and tumors.
Aiting Wang, Aiting Wang, Mengdi Yang, Rui Liang, Fangming Zhu, Fangming Zhu, Fangming Zhu, Fuxiang Zhu, Fuxiang Zhu, Xinnan Liu, Yichao Han, Ruirong Lin, Xiaoxia Wang, Dan Li, Hecheng Li, Xiaojun Yuan, Hui Zhao, Bin Li   +17 more
doaj   +1 more source