Results 61 to 70 of about 4,874,341 (306)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
OncoImmunologyRegulatory T (Treg) cells are critical in shaping an immunosuppressive microenvironment to favor tumor progression and resistance to therapies. However, the heterogeneity and function of Treg cells in esophageal squamous cell carcinoma (ESCC) remain ...
Min Ma +12 more
doaj +1 more source
Vascular normalization confers an endothelial immune suppressive gene expression profile
Molecular Oncology, EarlyView.We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley +1 more source
Utilizing Regulatory T Cells Against Rheumatoid Arthritis
Frontiers in Oncology, 2014 Regulatory T (Treg) cells are essential for normal immune surveillance systems, and their dysfunction leads to development of diseases, such as autoimmune disorders.
Mohammad eHaque +4 more
doaj +1 more source
iScience, 2021 Summary: Regulatory T cells induced by B cells (Treg-of-B cells), a distinct Foxp3- Treg cell subset, have established the roles in the suppression of inflammatory conditions, including asthma and intestinal inflammation.
Jing-Hui Huang, Bor-Luen Chiang
doaj +1 more source
Oncotarget, 2015 Regulatory T (Treg) cells safeguard against autoimmunity and overshooting inflammation. During their development in the thymus, Treg cells are selected by stronger autoantigenic T cell receptor (TCR) signals than conventional T cells. These TCR signals are critically important for the initiation of two key lineage defining events, namely induction of ...
Christoph, Drees +2 more
openaire +2 more sources
Treg cells subset profiles in HICs and control groups.
, 2020 (A) Frequencies of total Treg cells (CD4+CD25highFoxp3+). (B) Frequencies of activated (CD45RA-Foxp3high) Treg cells. (C) Frequencies of resting (CD45RA+Foxp3low) Treg cells; (D) Frequencies of non-suppressive (CD45RA-Foxp3low) Treg cells.
Diogo G. Caetano (5500967) +9 more
core +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
, 2017 Th17 and regulatory T (Treg) cells are integral in maintaining immune homeostasis and Th17–Treg imbalance is associated with inflammatory immunosuppression in cancer. Here we show that Th17 cells are a source of tumour-induced Foxp3+ cells.
Stephanie Downs-Canner +7 more
core +1 more source