Results 61 to 70 of about 12,132,339 (300)

Foxp3 Post-translational Modifications and Treg Suppressive Activity

Frontiers in Immunology, 2019
Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which can suppress the immune response via multiple distinct mechanisms.
Guoping Deng, Xiaomin Song, Shigeyoshi Fujimoto, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo, Yasuhiro Nagai, Mark I. Greene   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Lymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma

OncoImmunology
Regulatory T (Treg) cells are critical in shaping an immunosuppressive microenvironment to favor tumor progression and resistance to therapies. However, the heterogeneity and function of Treg cells in esophageal squamous cell carcinoma (ESCC) remain ...
Min Ma, Liang Li, Shu-Han Yang, Chuan Huang, Weitao Zhuang, Shujie Huang, Xin Xia, Yong Tang, Zijun Li, Zhi-Bin Zhao, Qingyun Chen, Guibin Qiao, Zhe-Xiong Lian   +12 more
doaj   +1 more source

Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase.

PLoS ONE, 2013
Although the cell-to-cell contact between CD4(+)Foxp3(+) regulatory T (Treg) and their target cells is important for the suppressor function of Treg cells, the regulation of this process is not well understood.
Takashi Tomiyama, Yoshihiro Ueda, Tomoya Katakai, Naoyuki Kondo, Kazuichi Okazaki, Tatsuo Kinashi   +5 more
doaj   +1 more source

Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment. [PDF]

PLoS ONE, 2012
BACKGROUND: Multiple myeloma (MM) is a plasma cell malignancy frequently associated with impaired immune cell numbers and functions. In MM, several studies have previously shown that CD4 regulatory T (Treg) cells hamper effector T cell functions and ...
Karthick Raja Muthu Raja, Lenka Kubiczkova, Lucie Rihova, Martin Piskacek, Pavla Vsianska, Renata Hezova, Ludek Pour, Roman Hajek   +7 more
doaj   +1 more source

Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

Advanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham, Marlon de Gast, Liubov Babii, Sabine Kruijer, Theo M. Bestebroer, Mathilde Richard, Mathieu Claireaux, S. Marieke van Ham, Jelle de Wit, Cécile A. C. M. van Els, Anja ten Brinke, Marit J. van Gils   +11 more
wiley   +1 more source

Differential regulation of Treg stability in human naïve and effector Treg subsets by TGFβ-signaling via ARKADIA-SKI axis

Frontiers in Immunology
IntroductionThe human FOXP3+ regulatory T (Treg) cells, a subset of CD4+ T cells with immunosuppressive function, are essential for the maintenance of immune homeostasis and tolerance.
Fan Yang, Alexis Yanes, Miao Li, Patrick Heizer, Ivan Linatoc, Michael E. Stephens, Yang Song, Tatiana Ort, Kyle J. Bednar, Yasuhiro Ikeda, Zengli Guo   +10 more
doaj   +1 more source

Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity

Frontiers in Immunology, 2018
While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, the regulatory response mediated by Treg cells upon infection by ...
Cintia L. Araujo Furlan, Cintia L. Araujo Furlan, Jimena Tosello Boari, Jimena Tosello Boari, Constanza Rodriguez, Constanza Rodriguez, Fernando P. Canale, Fernando P. Canale, Facundo Fiocca Vernengo, Facundo Fiocca Vernengo, Santiago Boccardo, Santiago Boccardo, Cristian G. Beccaria, Cristian G. Beccaria, Véronique Adoue, Véronique Adoue, Véronique Adoue, Olivier Joffre, Olivier Joffre, Olivier Joffre, Adriana Gruppi, Adriana Gruppi, Carolina L. Montes, Carolina L. Montes, Eva V. Acosta Rodriguez, Eva V. Acosta Rodriguez   +25 more
doaj   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Targeting the CBM complex causes Treg cells to prime tumors for immune checkpoint therapy

Nature, 2019
Solid tumours are infiltrated by effector T cells with the potential to control or reject them, as well as by regulatory T (Treg) cells that restrict the function of effector T cells and thereby promote tumour growth1.
M. D. Pilato, Edward Y. Kim, B. Cadilha, Jasper N. Prüßmann, M. Nasrallah, Davide Seruggia, Shariq M. Usmani, S. Misale, V. Zappulli, Esteban Carrizosa, Vinidhra Mani, M. Ligorio, Ross D. Warner, B. Medoff, F. Marangoni, A. Villani, T. Mempel   +16 more
semanticscholar   +1 more source