Results 51 to 60 of about 132,388 (166)

TCR signals fuel Treg cells

Oncotarget, 2015
Regulatory T (Treg) cells safeguard against autoimmunity and overshooting inflammation. During their development in the thymus, Treg cells are selected by stronger autoantigenic T cell receptor (TCR) signals than conventional T cells. These TCR signals are critically important for the initiation of two key lineage defining events, namely induction of ...
Christoph, Drees, J Christoph, Vahl, Marc, Schmidt-Supprian   +2 more
openaire   +2 more sources

Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity

Cell Reports, 2017
Th17 cells are potent mediators in autoimmune diseases, and RORγt is required for their development. Recent studies have shown that RORγt+ Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study,
Byung-Seok Kim, Huiping Lu, Kenji Ichiyama, Xiang Chen, Yi-Bing Zhang, Nipun A. Mistry, Kentaro Tanaka, Young-hee Lee, Roza Nurieva, Li Zhang, Xuexian Yang, Yeonseok Chung, Wei Jin, Seon Hee Chang, Chen Dong   +14 more
doaj   +1 more source

Treg cells promote plaque regression [PDF]

Nature Reviews Cardiology, 2020
A new study shows that regulatory T cells have essential roles in atherosclerotic plaque regression by promoting the resolution of plaque inflammation through suppression of macrophage and T cell pro-inflammatory responses and induction of a pro-resolving macrophage phenotype.
openaire   +2 more sources

New Paradigm in the Role of Regulatory T Cells During Pregnancy

Frontiers in Immunology, 2019
Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal tolerance induced by CD4+CD25+FoxP3+ regulatory T (Treg) cells is established during pregnancy.
Sayaka Tsuda, Akitoshi Nakashima, Tomoko Shima, Shigeru Saito   +3 more
doaj   +1 more source

New insights into Regulatory T cells：exosome and non-coding RNA mediated regulation of homeostasis, and resident regulatory T cells

Frontiers in Immunology, 2016
Regulatory T (Treg) cells are a population of cells that are heterogeneous in origin and in functional activity. Treg cells constitute an essential counterbalance to adaptive immune responses.
Peiyao Li, Peiyao Li, Peiyao Li, Changhong Liu, Changhong Liu, Changhong Liu, Zhibin Yu, Zhibin Yu, Zhibin Yu, Minghua Wu, Minghua Wu, Minghua Wu   +11 more
doaj   +1 more source

Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised

BMC Immunology, 2018
Background The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells.
Kari J. Dugger, Taylor Chrisman, Sarah L. Sayner, Parker Chastain, Kacie Watson, Robert Estes   +5 more
doaj   +1 more source

IPEX syndrome and human Treg cells

Japanese Journal of Clinical Immunology, 2010
CD4(+)CD25(+) T cells which have also been described as regulatory T cells (Treg), have immune inhibitory functions in the immune system. This population inhibits excessive immune responses, such as those present in patients with autoimmune disease, allergy and inflammation, and plays an important role in maintenance of immunological homeostasis.
Keisuke, Otsubo, Hirokazu, Kanegane, Ichiro, Kobayashi, Toshio, Miyawaki   +3 more
openaire   +3 more sources

Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4+ T cell differentiation

iScience
Summary: In colorectal cancer (CRC), increased numbers of tumor-infiltrating CD4+ regulatory T (Treg) cells correlate with tumor development, immunotherapy failure, and poor prognosis. To assess how CRC tumors directly modulate Treg cell differentiation,
Sonia Aristin Revilla, Cynthia L. Frederiks, Stefan Prekovic, Enric Mocholi, Onno Kranenburg, Paul J. Coffer   +5 more
doaj   +1 more source

NKG2D+CD4+ T Cells Kill Regulatory T Cells in a NKG2D-NKG2D Ligand- Dependent Manner in Systemic Lupus Erythematosus

Scientific Reports, 2017
Systemic lupus erythematosus (SLE) features a decreased pool of CD4+CD25+Foxp3+ T regulatory (Treg) cells. We had previously observed NKG2D+CD4+ T cell expansion in contrast to a decreased pool of Treg cells in SLE patients, but whether NKG2D+CD4+ T ...
Di Yang, Zhiqiang Tian, Mengjie Zhang, Weibing Yang, Jun Tang, Yuzhang Wu, Bing Ni   +6 more
doaj   +1 more source

Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation

Cell Reports, 2018
Summary: Psoriasis is a chronic relapsing, remitting interleukin (IL)-23/IL-17-driven skin disease mediated by the interplay of T cells and polymorphonuclear granulocytes. Although preclinical studies have provided insights into the mechanisms of disease
Tom Hartwig, Pascale Zwicky, Bettina Schreiner, Nikhil Yawalkar, Phil Cheng, Alexander Navarini, Reinhard Dummer, Lukas Flatz, Curdin Conrad, Christoph Schlapbach, Burkhard Becher   +10 more
doaj   +1 more source