Results 21 to 30 of about 132,388 (166)
Treg Cells Protect Dopaminergic Neurons against MPP+ Neurotoxicity via CD47-SIRPA Interaction
Cellular Physiology and Biochemistry, 2017 Background/Aims: Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in ...
Yan Huang +4 more
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Expression of IL-37 Induces a Regulatory T-Cell-like Phenotype and Function in Jurkat Cells
Cells, 2022 The anti-inflammatory cytokine interleukin-37 (IL-37) plays a key role in inhibiting innate and adaptive immunity. Past results have shown that IL-37 is elevated in human Treg cells compared to other T cell subsets and contributes to enhancing the Treg ...
Douglas Grant Osborne +2 more
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The role of thymus- and extrathymus-derived regulatory T cells in maternal-fetal tolerance
Frontiers in Immunology, 2023 Regulatory T (Treg) cells could be divided into thymus-derived Treg (tTreg) cells and peripherally derived Treg (pTreg) cells, and in vitro induced Treg (iTreg) cells.
Zhengjuan Li +7 more
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Treg cell abnormality and its potential treatments in patients with primary immune thrombocytopenia
Clinical and Translational Discovery, 2022 Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder. T regulatory cells (Treg), play an important role in the pathogenesis of the disease. Numerical and functional disorders of Treg cells were both demonstrated in ITP. Thymocyte
Lili Ji, Yunfeng Cheng
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Treg Cells, Life History, and Diversity [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Regulatory T cells expressing the FoxP3 transcription factor have a profound and nonredundant role in several aspects of immunological tolerance. We will review here the specification of this lineage, its population dynamics, and the diversity of subphenotypes that correlate with their diverse roles in controlling inflammation in a variety of settings.
Christophe, Benoist, Diane, Mathis
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Targeting Treg cells in cancer immunotherapy [PDF]
European Journal of Immunology, 2019 AbstractFoxp3‐expressing regulatory T (Treg) cells, which are indispensable for preventing autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into tumor tissues, which is often associated with poor prognosis in cancer patients.
Atsushi Tanaka, Shimon Sakaguchi
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Cell Transplantation, 2020 Regulatory T (Treg) cells have anti-inflammatory functions and heighten immune tolerance. The proportion and functions of Treg cells are perturbed in rheumatoid arthritis (RA), contributing to the excessive immune activation associated with this disease.
Shutong Li +3 more
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‘Repair’ Treg Cells in Tissue Injury [PDF]
Cellular Physiology and Biochemistry, 2017 Studies in mice and humans have elucidated an important role for Tregs in promoting tissue repair and restoring tissue integrity. Emerging evidence has revealed that Tregs promoted wound healing and repair processes at multiple tissue sites, such as the heart, liver, kidney, muscle, lung, bone and central nervous system.
Chaoqi Zhang +5 more
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Frontiers in Immunology, 2019 Several mechanisms of immune suppression have been attributed to Foxp3+ T regulatory cells (Treg) including modulation of target cells via inhibition of cell proliferation, alteration of cytokine secretion, and modification of cell phenotype, among ...
Mauricio Campos-Mora +9 more
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Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells
Cell Reports, 2017 Summary: Foxp3+ regulatory T (Treg) cells, which suppress immune responses, are highly proliferative in vivo. However, it remains unclear how the active replication of Treg cells is maintained in vivo. Here, we show that branched-chain amino acids (BCAAs)
Kayo Ikeda +20 more
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