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The Fate of Human Treg Cells [PDF]
Immunity, 2009 In this issue of Immunity, Miyara et al. (2009) demonstrate that FoxP3(+) cells in human peripheral blood are heterogeneous in function, and CD45RA expression defines their different stages of differentiation.
BATTAGLIA, MARCO MARIA +1 more
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Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications
Frontiers in Immunology, 2021 Regulatory T (Treg) cells are indispensable for immune homeostasis due to their roles in peripheral tolerance. As the master transcription factor of Treg cells, Forkhead box P3 (Foxp3) strongly regulates Treg function and plasticity.
Yi Dong, Cuiping Yang, F. Pan
semanticscholar +1 more source
Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. [PDF]
PLoS ONE, 2012 BACKGROUND: Regulatory T (Treg) cells play an important role in the maintenance of immune system homeostasis. Multiple myeloma (MM) is a plasma cell disorder frequently associated with impaired immune cell numbers and functions. METHODS: We analyzed Treg
Karthick Raja Muthu Raja +5 more
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Nature Immunology, 2021 The diversity of regulatory T (Treg) cells in health and in disease remains unclear. Individuals with colorectal cancer harbor a subpopulation of RORγt+ Treg cells with elevated expression of β-catenin and pro-inflammatory properties.
Jasmin Quandt +16 more
semanticscholar +1 more source
Autocrine TGF-β1 Maintains the Stability of Foxp3+ Regulatory T Cells via IL-12Rβ2 Downregulation
Biomolecules, 2020 Transforming growth factor beta 1 (TGF-β1) is an immunosuppresive cytokine that plays an essential role in immune homeostasis. It is well known that regulatory T (Treg) cells express TGF-β1; however, the role of autocrine TGF-β1 in the development ...
Garam Choi +4 more
doaj +1 more source
Dual targeting of CTLA-4 and CD47 on Treg cells promotes immunity against solid tumors
Science Translational Medicine, 2021 Selective CD47 blockade on CTLA-4high tumor-infiltrating Treg cells reduces systemic toxicity and enhances antitumor immunity. Targeting Treg cells Depletion of regulatory T (Treg) cells is an attractive strategy to promote antitumor immunity.
A. Zhang +8 more
semanticscholar +1 more source
In vitro Differentiation of Thymic Treg Cell Progenitors to Mature Thymic Treg Cells [PDF]
BIO-PROTOCOL, 2019 Thymic Treg cell differentiation occurs via a two-step process. Step one generates Treg cell progenitors (TregP) and is driven by strong TCR interactions with antigens presented in the thymus. Step two is initiated by activation of STAT5 via IL-2, or IL-15, leading to mature Treg cells capable of emigrating from the thymus and mediating immune ...
David Owen, Michael Farrar
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Frontiers in Immunology, 2021 FOXP3+ regulatory T cells (Treg cells) are a specialized population of CD4+ T cells that restrict immune activation and are essential to prevent systemic autoimmunity.
Justin Jacobse +11 more
doaj +1 more source
Fat Treg cells: a liaison between the immune and metabolic systems
Nature Medicine, 2009 Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. These findings raise the question of how fat inflammation can escape the powerful armamentarium of cells and molecules ...
M. Feuerer +10 more
semanticscholar +1 more source
Cell Reports, 2020 Summary: Regulatory T (Treg) cells integrate diverse environmental signals to modulate their function for optimal suppression. Translational regulation represents a favorable mechanism for Treg cell environmental sensing and adaptation. In this study, we
Yujian H. Yang +9 more
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