Results 11 to 20 of about 12,132,339 (300)

Regulation of Treg cells by cytokine signaling and co-stimulatory molecules. [PDF]

Front Immunol
CD4+CD25+Foxp3+ regulatory T cells (Tregs), a vital component of the immune system, are responsible for maintaining immune homeostasis and preventing excessive immune responses.
Zong Y, Deng K, Chong WP.
europepmc   +2 more sources

Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

Cell Reports, 2019
The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive.
Maheshwor Timilshina, Suman Acharya, Liyuan Jiang   +2 more
exaly   +2 more sources

Untangling the Knots of Regulatory T Cell Therapy in Solid Organ Transplantation

Frontiers in Immunology, 2022
Numerous preclinical studies have provided solid evidence supporting adoptive transfer of regulatory T cells (Tregs) to induce organ tolerance. As a result, there are 7 currently active Treg cell-based clinical trials in solid organ transplantation ...
Gabriel Orozco, Meera Gupta, Meera Gupta, Roberto Gedaly, Roberto Gedaly, Roberto Gedaly, Francesc Marti, Francesc Marti, Francesc Marti   +8 more
doaj   +1 more source

Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation

Immunity, 2023
Summary Obesity is a major risk factor for psoriasis, but how obesity disrupts the regulatory mechanisms that keep skin inflammation in check is unclear.
Pulavendran Sivasami, Cody Elkins, Pamela P. Diaz-Saldana, K. Goss, Amy Peng, Michael Hamersky, Jennifer Bae, Miaoer Xu, B. Pollack, E. Horwitz, Christopher D. Scharer, L. Seldin, Chaoran Li   +12 more
semanticscholar   +1 more source

CD1d-independent NK1.1+ Treg cells are IL2-inducible Foxp3+ T cells co-expressing immunosuppressive and cytotoxic molecules

Frontiers in Immunology, 2022
Regulatory T cells (Treg) play pivotal roles in maintaining self-tolerance and preventing immunological diseases such as allergy and autoimmunity through their immunosuppressive properties.
Hyun Jung Park, Sung Won Lee, Yun Hoo Park, Tae-Cheol Kim, Luc Van Kaer, Seokmann Hong   +5 more
doaj   +1 more source

Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

Nature Medicine, 2022
Approximately 60% of patients with large B cell lymphoma treated with chimeric antigen receptor (CAR) T cell therapies targeting CD19 experience disease progression, and neurotoxicity remains a challenge.
Zinaida Good, J. Spiegel, B. Sahaf, Meena B. Malipatlolla, Zachary J Ehlinger, Sreevidya Kurra, Moksha H Desai, Warren D. Reynolds, Anita Wong Lin, Panayiotis Vandris, Fang Wu, Snehit Prabhu, M. P. Hamilton, J. Tamaresis, Paul J. Hanson, Shabnum Patel, S. Feldman, M. Frank, John H. Baird, Lori S. Muffly, Gursharan K. Claire, Juliana K. Craig, K. Kong, D. Wagh, J. Coller, S. Bendall, R. Tibshirani, S. Plevritis, D. Miklos, C. Mackall   +29 more
semanticscholar   +1 more source

Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells

Scientific Reports, 2022
The CD4+ regulatory T (Treg) cell lineage, defined by FOXP3 expression, comprises thymus-derived (t)Treg cells and peripherally induced (p)Treg cells. As a model for Treg cells, studies employ TGF-β-induced (i)Treg cells generated from CD4+ conventional ...
Mark Mensink, Ellen Schrama, Eloy Cuadrado, Derk Amsen, Sander de Kivit, Jannie Borst   +5 more
doaj   +1 more source

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Immunosuppressive Foxp3-expressing regulatory T cells (Tregs) in tumor tissues are assumed to be clonally expanding via recognizing tumor-associated antigens.
Y. Kidani, W. Nogami, Y. Yasumizu, A. Kawashima, A. Tanaka, Yudai Sonoda, Yumi Tona, K. Nashiki, Reimi Matsumoto, Masaki Hagiwara, Motonao Osaki, K. Dohi, T. Kanazawa, A. Ueyama, Mai Yoshikawa, Tetsuya Yoshida, M. Matsumoto, K. Hojo, Satomi Shinonome, H. Yoshida, Michinari Hirata, Miya Haruna, Y. Nakamura, D. Motooka, D. Okuzaki, Y. Sugiyama, M. Kinoshita, T. Okuno, T. Kato, K. Hatano, M. Uemura, R. Imamura, K. Yokoi, A. Tanemura, Y. Shintani, T. Kimura, N. Nonomura, H. Wada, M. Mori, Y. Doki, N. Ohkura, S. Sakaguchi   +41 more
semanticscholar   +1 more source

Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus [PDF]

Brazilian Journal of Medical and Biological Research, 2014
Regulatory T (TREG) cells play an important role in maintaining immune tolerance and avoiding autoimmunity. We analyzed the expression of membrane molecules in TREG and effector T cells in systemic lupus erythematosus (SLE).
D. Mesquita Júnior, W.M. Cruvinel, J.A.P. Araujo, K.C. Salmazi, E.G. Kallas, L.E.C. Andrade   +5 more
doaj   +3 more sources

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Nature Communications, 2021
Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in experimental gliomas.
Zohreh Amoozgar, Jonas Kloepper, Jun Ren, R. Tay, S. Kazer, Evgeny Kiner, S. Krishnan, Jessica M Posada, Mitrajit Ghosh, E. Mamessier, Christina S. F. Wong, G. Ferraro, Ana L. Batista, Nan Wang, Mark D. Badeaux, S. Roberge, Lei Xu, P. Huang, A. Shalek, D. Fukumura, Hye-Jung Kim, R. Jain   +21 more
semanticscholar   +1 more source