Results 11 to 20 of about 132,388 (166)
The role of Treg cells in colorectal cancer and the immunotherapy targeting Treg cells. [PDF]
Front ImmunolColorectal cancer (CRC) is among the most prevalent and lethal cancers globally, accounting for approximately 10% of all cancer cases and deaths. Regulatory T (Treg) cells, which accumulate in CRC tissue, suppress anti-tumor immune responses and facilitate tumor progression.
Yu H, Yang R, Li M, Li D, Xu Y.
europepmc +4 more sources
Fragile Treg cells: Traitors in immune homeostasis?
Pharmacological ResearchRegulatory T (Treg) cells play a key role in maintaining immune tolerance and tissue homeostasis. However, in some disease microenvironments, Treg cells exhibit fragility, which manifests as preserved FoxP3 expression accompanied by inflammation and loss
Xiyu Song +7 more
doaj +3 more sources
Untangling the Knots of Regulatory T Cell Therapy in Solid Organ Transplantation
Frontiers in Immunology, 2022 Numerous preclinical studies have provided solid evidence supporting adoptive transfer of regulatory T cells (Tregs) to induce organ tolerance. As a result, there are 7 currently active Treg cell-based clinical trials in solid organ transplantation ...
Gabriel Orozco +8 more
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Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus [PDF]
Brazilian Journal of Medical and Biological Research, 2014 Regulatory T (TREG) cells play an important role in maintaining immune tolerance and avoiding autoimmunity. We analyzed the expression of membrane molecules in TREG and effector T cells in systemic lupus erythematosus (SLE).
D. Mesquita Júnior +5 more
doaj +3 more sources
Frontiers in Immunology, 2022 Regulatory T cells (Treg) play pivotal roles in maintaining self-tolerance and preventing immunological diseases such as allergy and autoimmunity through their immunosuppressive properties.
Hyun Jung Park +5 more
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Scientific Reports, 2022 The CD4+ regulatory T (Treg) cell lineage, defined by FOXP3 expression, comprises thymus-derived (t)Treg cells and peripherally induced (p)Treg cells. As a model for Treg cells, studies employ TGF-β-induced (i)Treg cells generated from CD4+ conventional ...
Mark Mensink +5 more
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The Fate of Human Treg Cells [PDF]
Immunity, 2009 In this issue of Immunity, Miyara et al. (2009) demonstrate that FoxP3(+) cells in human peripheral blood are heterogeneous in function, and CD45RA expression defines their different stages of differentiation.
BATTAGLIA, MARCO MARIA +1 more
openaire +3 more sources
Autocrine TGF-β1 Maintains the Stability of Foxp3+ Regulatory T Cells via IL-12Rβ2 Downregulation
Biomolecules, 2020 Transforming growth factor beta 1 (TGF-β1) is an immunosuppresive cytokine that plays an essential role in immune homeostasis. It is well known that regulatory T (Treg) cells express TGF-β1; however, the role of autocrine TGF-β1 in the development ...
Garam Choi +4 more
doaj +1 more source
Frontiers in Immunology, 2023 Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in the research of tumor progression. Treg cells have the function of inhibiting the immune effector cells, preventing tissue damage, and suppressing inflammation ...
Xinyan Wu +10 more
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Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. [PDF]
PLoS ONE, 2012 BACKGROUND: Regulatory T (Treg) cells play an important role in the maintenance of immune system homeostasis. Multiple myeloma (MM) is a plasma cell disorder frequently associated with impaired immune cell numbers and functions. METHODS: We analyzed Treg
Karthick Raja Muthu Raja +5 more
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