Results 21 to 30 of about 533,773 (311)

CD1d-independent NK1.1+ Treg cells are IL2-inducible Foxp3+ T cells co-expressing immunosuppressive and cytotoxic molecules

open access: yesFrontiers in Immunology, 2022
Regulatory T cells (Treg) play pivotal roles in maintaining self-tolerance and preventing immunological diseases such as allergy and autoimmunity through their immunosuppressive properties.
Hyun Jung Park   +5 more
doaj   +1 more source

Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis [PDF]

open access: yes, 2013
Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity ...
Hands-Portman, Ian   +5 more
core   +1 more source

ΔIK17 Antigen: A Possible Early Marker of Cancer Development

open access: yesThe International Journal of Biological Markers, 1996
ΔIK17 is a 44 kD molecule located on the surface of T, B and NK cells in normal peripheral blood mononuclear cells (PBMC) (1). The portion of PBMC expressing ΔIK17 was determined in 52 patients with benign breast diseases, 182 patients with breast ...
S. Perez   +7 more
doaj   +1 more source

The influence of acupuncture TENS currents on the proliferation of cancer cells tested in vitro

open access: yesRehabilitacja Medyczna, 2019
Introduction: Transcutaneous Electrical Nerve Stimulation (TENS) is a very popular, non-pharmacological antianalgetic method. Nonetheless, knowledge on using this method is very limited in the treatment of patients with cancer anamnesis.
Marzena Pełczyńska   +3 more
doaj   +1 more source

Identification of an Immune Gene Signature Based on Tumor Microenvironment Characteristics in Colon Adenocarcinoma

open access: yesCell Transplantation, 2021
Tumor microenvironment (TME) changes are related to the occurrence and development of colon adenocarcinoma (COAD). This study aimed to analyze the characteristics of the immune microenvironment in CC, as well as the microenvironment’s relationship with ...
Ying Chen, Jia Zhao
doaj   +1 more source

The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes : control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway [PDF]

open access: yes, 2013
Organometallic half-sandwich complexes [M(p-cymene)(azo/imino-pyridine)X]+ where M = RuII or OsII and X ═ Cl or I, exhibit potent antiproliferative activity toward a range of cancer cells.
Sadler, P. J.   +2 more
core   +1 more source

The recurrent laryngeal nerve and extralaryngeal branches in relation to the inferior thyroid artery, Berry’s ligament, tracheal groove, and Zuckerkandl tubercle: an experience of 60 thyroidectomies [PDF]

open access: yesFolia Medica
Aim: The aim of this study was to examine the anatomical variations of the inferior laryngeal nerve compared with its extralaryngeal branches, the inferior thyroid artery, Berry’s ligament, the tracheal groove, and the tubercle of Zuckerkandl, as ...
Zoi Nitsa   +3 more
doaj   +3 more sources

On-Label or Off-Label? Overcoming Regulatory and Financial Barriers to Bring Repurposed Medicines to Cancer Patients

open access: yesFrontiers in Pharmacology, 2020
Repurposing of medicines has gained a lot of interest from the research community in recent years as it could offer safe, timely, and affordable new treatment options for cancer patients with high unmet needs.
Ciska Verbaanderd   +5 more
doaj   +1 more source

Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition

open access: yesExperimental and Molecular Medicine, 2019
Cancer: How a plant metabolite analog suppresses tumor growth A synthetic analog of a chemical found in fruit suppresses tumor growth by targeting an RNA-binding protein (hnRNPA2B1) and preventing the production of a pro-cancer regulatory factor.
Nak-Kyun Soung   +21 more
doaj   +1 more source

Real-Time Determination of the Cell-Cycle Position of Individual Cells within Live Tumors Using FUCCI Cell-Cycle Imaging

open access: yesCells, 2018
Most cytotoxic agents have limited efficacy for solid cancers. Cell-cycle phase analysis at the single-cell level in solid tumors has shown that the majority of cancer cells in tumors is not cycling and is therefore resistant to cytotoxic chemotherapy ...
Shuya Yano, Robert M. Hoffman
doaj   +1 more source

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