Results 11 to 20 of about 487,301 (268)

Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents

International Journal of Nanomedicine
Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic
Jakkree Tangthianchaichana, Shouying Du   +1 more
exaly   +1 more source

Hair follicle associated pluripotent (HAP) stem cells jump from transplanted whiskers to pelage follicles and stimulate hair growth

Scientific Reports, 2022
Stimulation of hair growth in hair loss has been a difficult goal to achieve. Hair follicle-associated pluripotent (HAP) stem cells express nestin and have been shown to differentiate to multiple cell types including keratinocytes, neurons, beating ...
Koya Obara, Jose Reynoso, Yuko Hamada, Yusuke Aoki, Yutaro Kubota, Noriyuki Masaki, Yasuyuki Amoh, Robert M. Hoffman   +7 more
doaj   +1 more source

An Open Access Database of Licensed Cancer Drugs

Frontiers in Pharmacology, 2021
A global, comprehensive and open access listing of approved anticancer drugs does not currently exist. Partial information is available from multiple sources, including regulatory authorities, national formularies and scientific agencies.
Pan Pantziarka, Pan Pantziarka, Rica Capistrano I, Arno De Potter, Liese Vandeborne, Gauthier Bouche   +5 more
doaj   +1 more source

An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model

Scientific Reports, 2021
In order to identify more effective therapy for recalcitrant osteosarcoma, we evaluated the efficacy of an mTOR-VEGFR inhibitor combination on tumor growth in a unique osteosarcoma patient-derived orthotopic xenograft (PDOX) mouse model derived from the ...
Hiromichi Oshiro, Yasunori Tome, Kentaro Miyake, Takashi Higuchi, Norihiko Sugisawa, Fuminori Kanaya, Kotaro Nishida, Robert M. Hoffman   +7 more
doaj   +1 more source

Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity [PDF]

, 2011
Attaching peptides to metallodrugs may result in improved biological properties of the complexes. The potential use of cell penetrating peptides (CPPs) as cell delivery vectors is attractive, since directed cell uptake of (metallo)drugs remains a major ...
Rijt, Sabine H. van, Peter J. Sadler, Sadler, P. J., Hana Kostrhunova, Viktor Brabec, Brabec, V. (Viktor), Sabine H. van Rijt, Kostrhunova, Hana   +7 more
core   +1 more source

Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review

Cells, 2019
An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types
Kei Kawaguchi, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Takashi Murakami, Michiaki Unno, Robert M. Hoffman   +7 more
doaj   +1 more source

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs [PDF]

, 2009
This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging.
Rijt, Sabine H. van, Sadler, P. J.
core   +1 more source

Efficacy of Tumor-Targeting Salmonella typhimurium A1-R against Malignancies in Patient-Derived Orthotopic Xenograft (PDOX) Murine Models

Cells, 2019
We developed tumor-targeting Salmonella typhimurium (S. typhimurium) A1-R, a facultative anaerobe that is an auxotroph of leucine and arginine. The tumor-targeting efficacy of S. typhimurium A1-R was demonstrated in vivo and vitro using several malignant
Takashi Murakami, Yukihiko Hiroshima, Kentaro Miyake, Tasuku Kiyuna, Itaru Endo, Ming Zhao, Robert M. Hoffman   +6 more
doaj   +1 more source

Unusual DNA binding modes for metal anticancer complexes [PDF]

, 2009
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
core   +1 more source

Organometallic half-sandwich iridium anticancer complexes [PDF]

, 2011
The low-spin 5d6 IrIII organometallic half-sandwich complexes [(η5-Cpx)Ir(XY)Cl]0/+, Cpx = Cp*, tetramethyl(phenyl)cyclopentadienyl (Cpxph), or tetramethyl(biphenyl)cyclopentadienyl (Cpxbiph), XY = 1,10-phenanthroline (4−6), 2,2′-bipyridine (7−9 ...
Liu, Zhe, Bruijnincx, P.C.A., Brabec, V., Clarkson, Guy J., Sally A. Fletcher, Liu, Z., Vrana, O., Guy J. Clarkson, Fletcher, Sally A., Vrana, Oldrich, Salassa, Luca, Brabec, V. (Viktor), Fletcher, S.A., Kisova, A., Peter J. Sadler, Clarkson, G.J., Pizarro, A.M., Viktor Brabec, Bruijnincx, Pieter C. A., Oldrich Vrana, Sadler, P. J., Pieter C. A. Bruijnincx, Zhe Liu, Salassa, L., Luca Salassa, Habtemariam, A., Inorganic Chemistry and Catalysis, Sub Inorganic Chemistry and Catalysis, Pizarro, Ana M., Sadler, Peter J., Ana M. Pizarro, Kisova, Anna, Habtemariam, Abraha, Abraha Habtemariam, Anna Kisova   +34 more
core   +1 more source