Results 31 to 40 of about 533,773 (311)
Development of an interfering peptide M1-20 with potent anti-cancer effects by targeting FOXM1
Cell Death and Disease, 2023 Disrupting protein–protein interactions (PPIs) has emerged as a promising strategy for cancer drug development. Interfering peptides disrupting PPIs can be rationally designed based on the structures of natural sequences mediating these interactions ...
Huitong Bu +8 more
doaj +1 more source
A Novel Alkylating Agent, Glufosfamide, Enhances the Activity of Gemcitabine In Vitro, In Vivo
Neoplasia: An International Journal for Oncology Research, 2007 Glufosfamide is an alkylating agent consisting of iphosphoramide mustard conjugated to glucose that is currently included in clinical studies of pancreatic cancer.
W. Steve Ammons +4 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Isolated pancreatic metastasis from Merkel cell carcinoma: a case report
Journal of Rare DiseasesMerkel cell carcinoma (MCC) is a rare type of skin cancer. It is an aggressive neuroendocrine carcinoma with a high tendency for local recurrence, lymphatic and distant metastasis.
Maria Igoumenidi +6 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
ΔIK17: An Antigen Expressed on Human Lymphocytes
The International Journal of Biological Markers, 1996 Anti-ΔIK17 monoclonal antibody was produced by fusing SP2/0/Ag14 myeloma with spleen cells of BALB/c mice immunized with normal human thymocytes. AΔIK17 antibody recognizes a 44kD cell surface protein detected on human lymphocytes.
R. Sotiriadou +5 more
doaj +1 more source
The development of an anti-cancer peptide M1-21 targeting transcription factor FOXM1
Cell & Bioscience, 2023 Background Transcription factor FOXM1 is a potential target for anti-cancer drug development. An interfering peptide M1-21, targeting FOXM1 and FOXM1-interacting proteins, is developed and its anti-cancer efficacy is evaluated.
Haojie Cheng +9 more
doaj +1 more source
Organometallic Anticancer Compounds
Journal of Medicinal Chemistry, 2010 The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still used in more than 50% of the treatment regimes for patients suffering from cancer, is highly needed.1,2 Despite their tremendous success, these platinum compounds suffer from two main disadvantages: they are inefficient against platinum-resistant tumors ...
Gasser, Gilles +2 more
openaire +4 more sources
Coupling dichloroacetate treatment with curcumin significantly enhances anticancer potential
, 2018 [[abstract]]BACKGROUND/AIM: Dichloroacetate (DCA) and curcumin have been shown to be potent drug candidates in cancer therapy. Our study aimed to investigate the combined effects of DCA and essential oil-blended curcumin (ECUR) using the hepatoma Huh-7 ...
Kan, PC;Chang, YJ;Chien, CS;Su, CY;Fang, HW
core +1 more source
Metal complexes as DNA intercalators [PDF]
, 2011 DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this mode of DNA binding has since attracted considerable research ...
Peter J. Sadler +3 more
core +1 more source