Results 61 to 70 of about 487,301 (268)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

TLR4-dependent effects of ISAg treatment on conventional T cell polarization in vivo

Animal Cells and Systems, 2019
We recently demonstrated that the polysaccharide component of the Korean medicinal herb Angelica gigas (immuno-stimulatory fraction of A. gigas; ISAg) induces anticancer effects in mice by activating natural killer (NK) and natural killer T (NKT) cells ...
Sung Won Lee, Hyun Jung Park, Seo Hyun Kim, Sooyong Shin, Kyung Hee Kim, Sang Jae Park, Seokmann Hong, Sung Ho Jeon   +7 more
doaj   +1 more source

In vitro osteoblastic differentiation of mesenchymal stem cells generates cell layers with distinct properties

Stem Cell Research & Therapy, 2018
Background Differentiation of mesenchymal stem cells to osteoblasts is widely performed in research laboratories. Classical tests to prove this differentiation employ procedures such as cell fixation, cell lysis or cell scraping.
Hanna Hanna, Lluis M. Mir, Franck M. Andre   +2 more
doaj   +1 more source

Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells

Frontiers in Cell and Developmental Biology, 2020
Colon cancer is one of the leading causes of cancer-related death in the world. The development of new drugs and therapeutic strategies for patients with colon cancer are urgently needed.
Lin Hong, Lin Hong, Jundixia Chen, Fang Wu, Fengjiao Wu, Xin Shen, Peisen Zheng, Rongrong Shao, Kongqin Lu, Zhiguo Liu, Daoxing Chen, Guang Liang, Yuepiao Cai, Peng Zou, Peng Zou, Peng Zou, Yiqun Xia   +16 more
doaj   +1 more source

Antitumor memory T-cells become functionally mature from 30 to 100 days in a mouse model of neoplasia [PDF]

, 2018
Background: Late metastases develop from cancer of the breast, prostate, lung, kidney and malignant melanomas. Memory T-cells have excellent potential to prevent this devastating development in the same way that they routinely prevent emergence of latent
Bergman, Ira, Gao, Yanhua, Barmada, Mamdouha Abdab   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine

Molecular Therapy: Nucleic Acids, 2017
Pediatric cancers differ from adult tumors, especially by their very low mutational rate. Therefore, their etiology could be explained in part by other oncogenic mechanisms such as chromosomal rearrangements, supporting the possible implication of fusion
Célia Dupain, Anne Catherine Harttrampf, Giorgia Urbinati, Birgit Geoerger, Liliane Massaad-Massade   +4 more
doaj   +1 more source

CHAPTER 5. Anticancer Gold Compounds

, 2019
The use of gold in medicine has a long history that dates back to ancient times. In modern medicine, gold compounds have been applied as anti-inflammatory agents for the treatment of rheumatoid arthritis.
Chun-Nam Lok, Che, CM, Di Hu, Chi-Ming Che, Lok, CN, Hu, D   +5 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Management of malignant inferior vena cava syndrome (IVCS) by endovascular bridging stent placement

Radiology Case Reports
A 73-year-old male patient was admitted to the emergency department with dyspnea and severe edema in the lower extremities. The patient had been diagnosed with extensive small-cell lung cancer 15 months previously.
Manos Siderakis, MD, BSc, MSc, Georgia Papavasileiou, MD, MSc, Margarita Moutou, MD, MSc, George Gkeneralis, MD, MSc, PhD, Viktoria Kartsouni, MD, MSc, PhD, Myrsini Gkeli, MD, MSc   +5 more
doaj   +1 more source