Results 61 to 70 of about 552,206 (313)
Antitumor memory T-cells become functionally mature from 30 to 100 days in a mouse model of neoplasia [PDF]
, 2018 Background: Late metastases develop from cancer of the breast, prostate, lung, kidney and malignant melanomas. Memory T-cells have excellent potential to prevent this devastating development in the same way that they routinely prevent emergence of latent
Bergman, Ira +2 more
core +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine
Molecular Therapy: Nucleic Acids, 2017 Pediatric cancers differ from adult tumors, especially by their very low mutational rate. Therefore, their etiology could be explained in part by other oncogenic mechanisms such as chromosomal rearrangements, supporting the possible implication of fusion
Célia Dupain +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Colon cancer is one of the leading causes of cancer-related death in the world. The development of new drugs and therapeutic strategies for patients with colon cancer are urgently needed.
Lin Hong +16 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Management of malignant inferior vena cava syndrome (IVCS) by endovascular bridging stent placement
Radiology Case ReportsA 73-year-old male patient was admitted to the emergency department with dyspnea and severe edema in the lower extremities. The patient had been diagnosed with extensive small-cell lung cancer 15 months previously.
Manos Siderakis, MD, BSc, MSc +5 more
doaj +1 more source
CHAPTER 5. Anticancer Gold Compounds
, 2019 The use of gold in medicine has a long history that dates back to ancient times. In modern medicine, gold compounds have been applied as anti-inflammatory agents for the treatment of rheumatoid arthritis.
Chun-Nam Lok +5 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Mode of action of anticancer peptides (ACPs) from amphibian origin
, 2022 S.635-643Although cancer belongs to one of the leading causes of death around the world, fortunately studies have shown that tumor cells have various targets that are susceptible to attack.
Hartke, Martin +2 more
core +1 more source
Metformin as an Anticancer Agent [PDF]
Trends in Pharmacological Sciences, 2018 Metformin has been a frontline therapy for type 2 diabetes (T2D) for many years. Its effectiveness in T2D treatment is mostly attributed to its suppression of hepatic gluconeogenesis; however, the mechanistic aspects of metformin action remain elusive.
Ales, Vancura +4 more
openaire +2 more sources