Results 41 to 50 of about 78,517 (164)

Local but Not Systemic Administration of Uridine Prevents Development of Antigen-Induced Arthritis. [PDF]

PLoS ONE, 2015
Uridine has earlier been show to down modulate inflammation in models of lung inflammation. The aim of this study was to evaluate the anti-inflammatory effect of uridine in arthritis.Arthritis was induced by intra-articular injection of mBSA in the knee ...
Sudeep Chenna Narendra, Jaya Prakash Chalise, Mattias Magnusson, Srinivas Uppugunduri   +3 more
doaj   +1 more source

Compartmentalization of Uridine and Uridine 5′-Monophosphate in Rat Liver Slices

Journal of Biological Chemistry, 1973
Abstract The metabolism of exogenous uridine, uridine 5'-monophosphate, and uracil by rat liver slices was studied using in vitro superfusion systems. Mixtures of 3H- and 14C-labeled uridine, uridine 5'-monophosphate, uracil, and orotic acid were superfused at a constant rate until an isotopic steady state was achieved.
J K, Tseng, E, Gurpide
openaire   +2 more sources

Indispensable residue for uridine binding in the uridine-cytidine kinase family

Biochemistry and Biophysics Reports, 2017
Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine. However, UCK of Thermus thermophilus HB8 (ttCK) phosphorylates only cytidine. This cytidine-restricted activity is thought to depend on Tyr93, although the precise mechanism remains unresolved.
Fumiaki Tomoike, Noriko Nakagawa, Kenji Fukui, Takato Yano, Seiki Kuramitsu, Ryoji Masui   +5 more
openaire   +3 more sources

Lipidomic and transcriptomic profiles provide new insights into the triacylglycerol and glucose handling capacities of the Arctic fox

Frontiers in Veterinary Science
The Arctic fox (Vulpes lagopus) is a species indigenous to the Arctic and has developed unique lipid metabolism, but the mechanisms remain unclear.
Yuhang Zhu, Yuan Yuan, Huazhe Si, Huazhe Si, Songze Li, Fei Zhao, Ruina Mu, Zihan Lin, Xiaoxu Wang, Qiang Qiu, Chao Xu, Lele Ji, Zhipeng Li, Zhipeng Li   +13 more
doaj   +1 more source

Crystal structure of 5-(dibenzofuran-4-yl)-2′-deoxyuridine

Acta Crystallographica Section E: Crystallographic Communications, 2017
The molecule of the title compound, C21H18N2O6, has a bent rather than a linear conformation supported by three intramolecular C—H...O hydrogen bonds. The packing in the crystal lattice is largely determined by interactions between hydrogen atoms with ...
Vijay Gayakhe, Anant Ramakant Kapdi, Yulia Borozdina, Carola Schulzke   +3 more
doaj   +1 more source

Anti-Inflammatory Responses Produced with Nippostrongylus brasiliensis-Derived Uridine via the Mitochondrial ATP-Sensitive Potassium Channel and Its Anti-Atherosclerosis Effect in an Apolipoprotein E Gene Knockout Mouse Model

Biomolecules
Atherosclerosis (AS) has become the leading cause of cardiovascular disease worldwide. Our previous study had observed that Nippostrongylus brasiliensis (Nb) infection or its derived products could inhibit AS development by inducing an anti-inflammatory ...
Yingshu Zhang, Xin Ding, Caiyi Yuan, Yougui Yang, Qiang Zhang, Jiakai Yao, Ying Zhang, Junhong Wang, Yang Dai   +8 more
doaj   +1 more source

Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease

Frontiers in Immunology
IntroductionInflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Colitis, has an unclear etiology.
Caiyi Yuan, Qiang Wang, Yuying Chen, Yuying Chen, Xin Ding, Qiang Zhang, Jiakai Yao, Bei Zhang, Yang Dai, Yang Dai, Hongxia Bai   +10 more
doaj   +1 more source

Dietary uridine improves lipid homeostasis in high-fat diet-induced obese mice by regulating liver gene expression and metabolomic profiles

Frontiers in Nutrition
IntroductionObesity is caused by excessive storage of adipose tissue and leads to metabolic disorders. Uridine exerts modulatory effects on lipid metabolism, but the regulatory mechanism in obesity needs further research.MethodsIn this study, the effects
Yilin Liu, Huihui Zhang, Huihui Zhang, Xudong Yang, Chunyan Xie   +4 more
doaj   +1 more source

Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model

Future Science OA
Aims To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin—administered alone and in combination—in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.Materials & Methods Oral doses of ...
Esam Y. Qnais, Muna Barakat, Rabaa Y. Athamneh, Mohammad A. A. Al-Najjar, Lujain F. Alzaghari, Dinesh Kumar Chellappan, Abdelrahim Alqudah   +6 more
doaj   +1 more source

Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation[S]

Journal of Lipid Research, 2013
We report in this study an intrinsic link between pyrimidine metabolism and liver lipid accumulation utilizing a uridine phosphorylase 1 transgenic mouse model UPase1-TG.
Thuc T. Le, Amy Ziemba, Yasuyo Urasaki, Eugene Hayes, Steven Brotman, Giuseppe Pizzorno   +5 more
doaj   +1 more source