Results 1 to 10 of about 56,630 (276)

Cytidine does not affect acute toxicity of intravenously administered choline

Folia Neuropathologica
Cytidine-5’-diphosphocholine (CDP-choline) is a key precursor for the intracellular synthesis of phosphatidylcholine and other phospholipids. Following either intravenous or oral application citicoline (CDP-choline of exogenous origin) undergoes quick ...
Kamil Synoradzki, Maciej Swiatkiewicz, Paweł Grieb   +2 more
doaj   +2 more sources

Promoting cytidine biosynthesis by modulating pyrimidine metabolism and carbon metabolic regulatory networks in Bacillus subtilis

Microbial Cell Factories
Background The modification of single or multiple genes via metabolic engineering can lead to the dysregulation of central metabolism and affect bacterial growth and metabolite accumulation.
Xiangjun Zhang, Lu Liu, Pilian Niu, Tong Ye, Wei Ding, Xiaobo Wei, Junnan Xu, Haitian Fang, Huiyan Liu   +8 more
doaj   +2 more sources

Systems metabolic engineering of a plasmid-free

Synthetic and Systems Biotechnology
Cytidine is an important precursor for nucleoside pharmaceuticals, but its fermentative production is constrained by competing degradation, poor selectivity of pyrimidine flux, insufficient precursor supply, and energy-redox imbalance.
Runze Zhao, Changgeng Li, Chaoye Xu, Zhichao Chen, Haibo Xiong, Zichen Yu, Tang'en Shi, Lanxiao Li, Meng Yuan, Ling Ma, Siyu Zhao, Hongyu Deng, Qingyang Xu   +12 more
doaj   +1 more source

Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein

eLife, 2014
The activation induced cytidine deaminase (AID) protein is known to initiate somatic hypermutation, gene conversion or switch recombination by cytidine deamination within the immunoglobulin loci.
Jean-Marie Buerstedde, Noel Lowndes, David G Schatz   +2 more
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Increased distribution of carbon metabolic flux during de novo cytidine biosynthesis via attenuation of the acetic acid metabolism pathway in Escherichia coli

Microbial Cell Factories
Acetic acid, a by-product of cytidine synthesis, competes for carbon flux from central metabolism, which may be directed either to the tricarboxylic acid (TCA) cycle for cytidine synthesis or to overflow metabolites, such as acetic acid.
Tong Ye, Wei Ding, Zhengxu An, Haojie Zhang, Xiaobo Wei, Junnan Xu, Huiyan Liu, Haitian Fang   +7 more
doaj   +1 more source

AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates

Nature Communications, 2018
The AID/APOBEC cytidine deaminase family are nucleic acid editors, important for antigen receptor expression and thought to have evolved along with vertebrate adaptive immunity.
Mei-Chen Liu, Wen-Yun Liao, Katherine M. Buckley, Shu Yuan Yang, Jonathan P. Rast, Sebastian D. Fugmann   +5 more
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Characteristics and efficacy of cytosine and cytidine deaminase [PDF]

مجلة التربية والعلم, 2007
The study concerned with determination of some properties of cytosine deaminase activity in serum and erythrocytes haemolysate in normal human individuals, by spectral method.
Qusay Chalabi, Zahraa Hammodat
doaj   +1 more source

RNA cytidine acetyltransferase of small-subunit ribosomal RNA: identification of acetylation sites and the responsible acetyltransferase in fission yeast, Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2014
The eukaryotic small-subunit (SSU) ribosomal RNA (rRNA) has two evolutionarily conserved acetylcytidines. However, the acetylation sites and the acetyltransferase responsible for the acetylation have not been identified.
Masato Taoka, Daisuke Ishikawa, Yuko Nobe, Hideaki Ishikawa, Yoshio Yamauchi, Goro Terukina, Hiroshi Nakayama, Kouji Hirota, Nobuhiro Takahashi, Toshiaki Isobe   +9 more
doaj   +1 more source

A circuitous route for in vitro multi-enzyme cascade production of cytidine triphosphate to overcome the thermodynamic bottleneck

Bioresources and Bioprocessing
Cytidine triphosphate (CTP), as a substance involved in the metabolism of phospholipids, proteins and nucleic acids, has precise drug effects and is a direct precursor for the synthesis of drugs such as citicoline.
Zonglin Li, Yahui Zhong, Zhoulei Qing, Zhimin Li   +3 more
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Multiple gene substitution by Target-AID base-editing technology in tomato

Scientific Reports, 2020
The use of Target activation-induced cytidine deaminase (Target-AID) base-editing technology with the CRISPR-Cas 9 system fused with activation-induced cytidine deaminase (AID) resulted in the substitution of a cytidine with a thymine.
Johan Hunziker, Keiji Nishida, Akihiko Kondo, Sanae Kishimoto, Tohru Ariizumi, Hiroshi Ezura   +5 more
doaj   +1 more source