ADP-Ribosylation of Cytidine: A Novel Nucleic Acid Modification Reversed by NADAR Hydrolases [PDF]
ToxinsADP-ribosylation of nucleic acids is a modification found in both eukaryotes and bacteria, where it contributes to genome maintenance but can also serve as a toxic mechanism used by bacterial toxins to disrupt essential cellular processes.
Petra Mikolčević +6 more
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Indispensable residue for uridine binding in the uridine-cytidine kinase family
Biochemistry and Biophysics Reports, 2017 Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine. However, UCK of Thermus thermophilus HB8 (ttCK) phosphorylates only cytidine.
Fumiaki Tomoike +2 more
exaly +3 more sources
Integrated amplification of NADPH-regenerating modules enhances cytidine biosynthesis in Escherichia coli [PDF]
Synthetic and Systems BiotechnologyIn Escherichia coli, cofactor imbalance serves as a crucial limiting factor in cytidine biosynthesis, with nicotinamide adenine dinucleotide phosphate (NADPH) insufficiency representing the principal metabolic barrier.
Lu Liu +7 more
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Transdifferentiation of α-1,3-galactosyltransferase knockout pig bone marrow derived mesenchymal stem cells into pancreatic -like cells by microenvironment modulation [PDF]
Asian-Australasian Journal of Animal Sciences, 2020 Objective To evaluate the pancreatic differentiation potential of α-1,3-galactosyltransferase knockout (GalTKO) pig-derived bone marrow-derived mesenchymal stem cells (BM-MSCs) using epigenetic modifiers with different pancreatic induction media. Methods
Imran Ullah +6 more
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Microwave-Assisted Synthesis of 5′-O-methacryloylcytidine Using the Immobilized Lipase Novozym 435
Molecules, 2022 Nucleobase building blocks have been demonstrated to be strong candidates when it comes to DNA/RNA-like materials by benefiting from hydrogen bond interactions as physical properties. Modifying at the 5′ position is the simplest way to develop nucleobase-
Sany Chea +2 more
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Fermentation, 2022 Cytidine is an antiviral and anticancer drug intermediate, its primary method of manufacture being fermentation. Uridine-cytidine kinase (UCK) catalyzes the reverse process of phosphorylation of cytidine to produce cytidylic acid, which influences ...
Fengmin Liu +5 more
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Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase. [PDF]
PLoS ONE, 2013 Deamination of 5-methylcytidine (5MeC) in DNA results in a G:T mismatch unlike cytidine (C) deamination which gives rise to a G:U pair. Deamination of C was generally considered to arise spontaneously.
Rodolphe Suspène +3 more
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Partial purification of cytidine deaminase from protoscoleces of Echinococcus granulosus [PDF]
Kirkuk Journal of Science, 2015 Cytidine deaminase (EC 3.5.4.5) has been partially purified from protoscoleces of Echinococcus granulosus by gel filteration chromatography using Sephadex G200 .The molecular weight of the enzyme determined by gel filteration was about 82000 dalton with ...
Husain F. Hassan, Jenan A.Saber
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Nature Communications, 2023 APOBEC’s are a family of cytidine deaminases that induce mutations in viruses to inhibit their replication and maintain cell integrity. Here, Manjunath et al show that APOBEC3B also inhibits viral replication by stimulating the innate immune sensor ...
Lavanya Manjunath +12 more
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Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti
Frontiers in Microbiology, 2021 Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature.
Longxiang Wang +6 more
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