Results 31 to 40 of about 56,630 (276)

Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins [PDF]

, 2009
The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure.
Göttle, Martin
core   +1 more source

Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification. [PDF]

PLoS Pathogens, 2005
The HIV-1 Vif protein counteracts the antiviral activity exhibited by the host cytidine deaminases APOBEC3G and APOBEC3F. Here, we show that defective vif alleles can readily be found in HIV-1 isolates and infected patients. Single residue changes in the
Viviana Simon, Veronique Zennou, Deya Murray, Yaoxing Huang, David D Ho, Paul D Bieniasz   +5 more
doaj   +2 more sources

Cytidine-Derived Hydrogels with Tunable Antibacterial Activities

, 2019
We herein report the preparation of hydrogels by the Ag+ ion induced assembly of cytidine and boronic acids. These hydrogels, presumably formed by an i-motif like arrangement of cytidine and its boronate ester analogues, possess excellent thixotropic and
Jyotirmayee Dash (1616845), Ritapa Chaudhuri (6752060), Tanima Bhattacharyya, Subhranshu Mandal (6945374), Subhranshu Mandal, Krishna Sundar Das, Ritapa Chaudhuri, Raju Mondal, Jyotirmayee Dash, Krishna Sundar Das (6171356), Tanima Bhattacharyya (4475041), Raju Mondal (20176)   +11 more
core   +2 more sources

Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells

Cell Death Discovery, 2022
Highly specific and potent inhibitors of dihydroorotate dehydrogenase (DHODH), an essential enzyme of the de novo pyrimidine ribonucleotide synthesis pathway, are in clinical trials for autoimmune diseases, viral infections and cancer.
Twana Alkasalias, Juan Zhang, Harsha Madapura, Basile Dalaroun, Oscar Bedoya Reina, Rolf Lewensohn, Kristina Viktorsson, Abbas Salihi, Suhas Darekar, Sonia Laín   +9 more
doaj   +1 more source

CDA (Cytidine Deaminase) [PDF]

, 2010
Review on CDA (Cytidine Deaminase), with data on DNA, on the protein encoded, and where the gene is ...
Y Saito, Saito, Y
core   +1 more source

Exploring ABOBEC3A and APOBEC3B substrate specificity and their role in HPV positive head and neck cancer

iScience, 2022
Summary: APOBEC3 family members are cytidine deaminases catalyzing conversion of cytidine to uracil. Many studies have established a link between APOBEC3 expression and cancer development and progression, especially APOBEC3A (A3A) and APOBEC3B (A3B ...
Christina Papini, Zechen Wang, Shalley N. Kudalkar, Travis Parke Schrank, Su Tang, Tomoaki Sasaki, Cory Wu, Brandon Tejada, Samantha J. Ziegler, Yong Xiong, Natalia Issaeva, Wendell G. Yarbrough, Karen S. Anderson   +12 more
doaj   +1 more source

Cytidine Deaminase Can Deaminate Fused Pyrimidine Ribonucleosides [PDF]

, 2021
The tolerance of Cytidine Deaminase (CDA) to expanded heterocycles is explored via three fluorescent cytidine analogues, where the pyrimidine core is fused to three distinct five-membered heterocycles at the 5/6 positions.
Tor, Yitzhak, Li, Yao, Ludford, Paul T., Yang, Shenghua, Ludford, Paul T   +4 more
core   +1 more source

Construction of a cytidine base editor based on Exopalaemon carinicauda cytidine deaminase and its application in crustacean genome editing

Aquaculture Reports, 2022
Economic crustaceans play important roles in aquaculture and create great benefits for the world agricultural economy. Studies have found that there are many single nucleotide polymorphism (SNP) sites in the crustacean genomes, which closely related to a
Yujie Liu, Kefan Xing, Zixuan Wu, Congcong Yan, Yuying Sun, Jiquan Zhang   +5 more
doaj   +1 more source

Increasing fidelity and efficiency by modifying cytidine base-editing systems in rice

Crop Journal, 2020
The efficiency of plant cytidine base-editing systems is limited, and unwanted mutations frequently occur in transgenic plants. We increased the cytidine editing frequency and fidelity of the plant base editor 3 (BE3) and targeted activation-induced ...
Ruiying Qin, Shengxiang Liao, Juan Li, Hao Li, Xiaoshuang Liu, Jianbo Yang, Pengcheng Wei   +6 more
doaj   +1 more source

Crystal structure of Arabidopsis thaliana cytidine deaminase

, 2020
Cytidine deaminase (CDA) catalyzes the (deoxy)cytidine deamination to (deoxy)uridine, which involves in the catabolic and salvage pathways of pyrimidine nucleotides in plants.
Wang, Jia, Wang, Xiao, Guo, Qi, Liu, Lin
core   +1 more source