Results 31 to 40 of about 80,345 (286)

APOBEC3A is a prominent cytidine deaminase in breast cancer.

PLoS Genetics, 2019
APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major source of mutagenesis in breast cancer (BRCA).
Luis M Cortez, Amber L Brown, Madeline A Dennis, Christopher D Collins, Alexander J Brown, Debra Mitchell, Tony M Mertz, Steven A Roberts   +7 more
doaj   +1 more source

15N NMR study of a mixture of uniformly labeled tRNAs [PDF]

, 1982
15N NMR spectra were taken of 15N-enriched tRNA extracted from bakers yeast; ammonium sulfate was used as a nitrogen source. The increase in the degree of denaturation of tRNA, which occurs with increase in temperature from 30 degrees C to 70 degrees C ...
Birdseye, Theresa R., Gonnella, Nina C., Nee, Michael, Roberts, John D.   +3 more
core   +1 more source

A New Method for Synthesis of Cytidine Diphosphate-Ethanolamine and Cytidine Diphosphate-Choline.

Chemical and Pharmaceutical Bulletin, 1962
Reaction of cytidine diphosphate (CDP) (II) with ethyleneimine (III) produced CDP-ethanolamine (IV), and methylation of the product with methyl iodide yielded CDP-choline (IX).
Y, SANNO, K, TANAKA
openaire   +3 more sources

The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2. [PDF]

PLoS ONE, 2016
Fluorocyclopentenylcytosine (RX-3117) is an orally available cytidine analog, currently in Phase I clinical trial. RX-3117 has promising antitumor activity in various human tumor xenografts including gemcitabine resistant tumors.
Dzjemma Sarkisjan, Joris R Julsing, Kees Smid, Daniël de Klerk, André B P van Kuilenburg, Rutger Meinsma, Young B Lee, Deog J Kim, Godefridus J Peters   +8 more
doaj   +1 more source

Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers

Cell Reports, 2022
Summary: Mutational signatures defined by single base substitution (SBS) patterns in cancer have elucidated potential mutagenic processes that contribute to malignancy.
Rachel A. DeWeerd, Eszter Németh, Ádám Póti, Nataliya Petryk, Chun-Long Chen, Olivier Hyrien, Dávid Szüts, Abby M. Green   +7 more
doaj   +1 more source

Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution [PDF]

, 2015
Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA ...
Bertram, JG, Chaurasiya, KR, Goodman, MF, Jaszczur, M, Mak, CH, Pham, P, Rueda, DS, Senavirathne, G   +7 more
core   +1 more source

Butterfly Effect in Cytarabine: Combined NMR-NQR Experiment, Solid-State Computational Modeling, Quantitative Structure-Property Relationships and Molecular Docking Study

Pharmaceuticals
Cytarabine (Ara-C) is a synthetic isomer of cytidine that differs from cytidine and deoxycytidine only in the sugar. The use of arabinose instead of deoxyribose hinders the formation of phosphodiester linkages between pentoses, preventing the DNA chain ...
Jolanta Natalia Latosińska, Magdalena Latosińska, Janez Seliger, Veselko Žagar, Tomaž Apih   +4 more
doaj   +1 more source

Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions

BMC Biology, 2020
Background Cytidine base editors (CBEs), composed of a cytidine deaminase fused to Cas9 nickase (nCas9), enable efficient C-to-T conversion in various organisms. However, current base editors can induce unwanted bystander C-to-T conversions when multiple
Zhiquan Liu, Siyu Chen, Huanhuan Shan, Yingqi Jia, Mao Chen, Yuning Song, Liangxue Lai, Zhanjun Li   +7 more
doaj   +1 more source

Construction of a cytidine base editor based on Exopalaemon carinicauda cytidine deaminase and its application in crustacean genome editing

Aquaculture Reports, 2022
Economic crustaceans play important roles in aquaculture and create great benefits for the world agricultural economy. Studies have found that there are many single nucleotide polymorphism (SNP) sites in the crustacean genomes, which closely related to a
Yujie Liu, Kefan Xing, Zixuan Wu, Congcong Yan, Yuying Sun, Jiquan Zhang   +5 more
doaj   +1 more source

Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model

Future Science OA
Aims To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin—administered alone and in combination—in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.Materials & Methods Oral doses of ...
Esam Y. Qnais, Muna Barakat, Rabaa Y. Athamneh, Mohammad A. A. Al-Najjar, Lujain F. Alzaghari, Dinesh Kumar Chellappan, Abdelrahim Alqudah   +6 more
doaj   +1 more source