Results 1 to 10 of about 1,037,544 (299)
HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editing
Molecular Therapy - Nucleic Acids, 2022 Recent advances in CRISPR-Cas9 techniques, especially the discovery of base and prime editing, have significantly improved our ability to make precise changes in the genome.
Guifeng Lin +2 more
exaly +5 more sources
Targeted RNA base editing for therapeutic: mechanisms and advances. [PDF]
Pharm Sci AdvRNA base editing, which enables RNA base modification through effector proteins guided by targeting systems, is a powerful technology to correct disease-associated point mutations.
Yan W, Weng X.
europepmc +2 more sources
Applications of Base Editing Technology in Modifications of Pig Genes
Guangdong nongye kexue, 2022 Pigs are highly valued in both agriculture and medicine. We can quickly improve the economic properties of pigs and develop human disease models via gene modification technologies.
Jiasheng PAN +5 more
doaj +1 more source
BMC Plant Biology, 2021 Background Virus-induced gene silencing (VIGS) is one of the most convenient and powerful methods of reverse genetics. In vitro-inoculation of plant virus is an important method for studying the interactions between viruses and plants.
Qili Liu +16 more
doaj +1 more source
Base and Prime Editing Technologies for Blood Disorders
Frontiers in Genome Editing, 2021 Nuclease-based genome editing strategies hold great promise for the treatment of blood disorders. However, a major drawback of these approaches is the generation of potentially harmful double strand breaks (DSBs).
Panagiotis Antoniou +2 more
doaj +1 more source
Plant genome editing: CRISPR, base editing, prime editing, and beyond
Grassland Research, 2022 The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) system is a fast‐growing, genome editing technology that has wide applications in identifying gene functions as well as improving agricultural ...
Yujie Xie +7 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2023 CRISPR-Cas9-based genome editing technologies, such as base editing, have the potential for clinical translation, but delivering nucleic acids into target cells in vivo is a major obstacle.
Cynthia D. Anderson +5 more
doaj +1 more source
Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]
, 2020 Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu +2 more
core +2 more sources
Target-AID-Mediated Multiplex Base Editing in Porcine Fibroblasts
Animals, 2021 Multiplex genome editing may induce genotoxicity and chromosomal rearrangements due to double-strand DNA breaks at multiple loci simultaneously induced by programmable nucleases, including CRISPR/Cas9. However, recently developed base-editing systems can
Soo-Young Yum, Goo Jang, Okjae Koo
doaj +1 more source
Systematic Exploration of Optimized Base Editing gRNA Design and Pleiotropic Effects with BExplorer
Genomics, Proteomics & Bioinformatics, 2023 Base editing technology is being increasingly applied in genome engineering, but the current strategy for designing guide RNAs (gRNAs) relies substantially on empirical experience rather than a dependable and efficient in silico design.
Gongchen Zhang +7 more
doaj +1 more source