Expanding the Editing Window of Cytidine Base Editors With the Rad51 DNA-Binding Domain in Rice
Frontiers in Plant Science, 2022 Recently developed base editors provide a powerful tool for plant research and crop improvement. Although a number of different deaminases and Cas proteins have been used to improve base editors the editing efficiency, and editing window are still not ...
Chunjie Wei +8 more
doaj +1 more source
Precise genome editing with base editors
Medical Review, 2023 Single-nucleotide variants account for about half of known pathogenic genetic variants in human. Genome editing strategies by reversing pathogenic point mutations with minimum side effects have great therapeutic potential and are now being actively ...
Liu Hongcai +3 more
doaj +1 more source
Analogies based video editing [PDF]
Multimedia Systems, 2005 A well-produced video always creates a strong impression on the viewer. However, due to the limitations of the camera, the ambient conditions or the skills of the videographer, the quality of captured videos sometimes falls short of one's expectations.
Wei-Qi Yan 0001 +2 more
openaire +2 more sources
Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors. [PDF]
, 2020 Adenine base editors, which were developed by engineering a transfer RNA adenosine deaminase enzyme (TadA) into a DNA editing enzyme (TadA*), enable precise modification of A:T to G⋮C base pairs. Here, we use molecular dynamics simulations to uncover the
Komor, Alexis C +2 more
core
Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes [PDF]
, 2018 The Cas9 endonuclease can be programmed by guide RNA to introduce sequence-specific breaks in genomic DNA. Thus, Cas9-based approaches present a range of novel options for genome manipulation and precision editing. African trypanosomes are parasites that
A Paix +46 more
core +2 more sources
Beyond seek and destroy: How to generate allelic series using genome editing tools [PDF]
, 2020 Genome editing tools have greatly facilitated the functional analysis of genes of interest by targeted mutagenesis. Many usable genome editing tools, including different site-specific nucleases and editor databases that allow single-nucleotide ...
Bes, Martine +10 more
core +3 more sources
Base Editors for Citrus Gene Editing [PDF]
Frontiers in Genome Editing, 2021 Base editors, such as adenine base editors (ABE) and cytosine base editors (CBE), provide alternatives for precise genome editing without generating double-strand breaks (DSBs), thus avoiding the risk of genome instability and unpredictable outcomes caused by DNA repair.
Xiaoen Huang, Yuanchun Wang, Nian Wang
openaire +4 more sources
Universal RNA editing in a human liver at the fetal stage [PDF]
, 2012 It is known that RNA editing occurs in human cells, which can change the information transmission from DNA to RNA and proteins. Most previous studies have focused on editing of the mRNAs. Here we reported that several kinds of RNAs, including miRNA, rRNA,
Chen, Huiping +4 more
core +1 more source
Promoter keyholes enable specific and persistent multi-gene expression programs in primary T cells without genome modification [PDF]
, 2020 Non-invasive epigenome editing is a promising strategy for engineering gene expression programs, yet potency, specificity, and persistence remain challenging.
Acosta, Reyes +25 more
core
Survey of tools for collaborative knowledge construction and sharing [PDF]
, 2007 The fast growth and spread of Web 2.0 environments have demonstrated the great willingness of general Web users to contribute and share various type of content and information.
Alani, Harith, Correndo, Gianluca
core +2 more sources