Results 31 to 40 of about 4,580,472 (190)

Development of a Simple and Quick Method to Assess Base Editing in Human Cells

Molecular Therapy: Nucleic Acids, 2020
Base editing is a form of genome editing that can directly convert a single base (C or A) to another base (T or G), which is of great potential in biomedical applications.
Xiujuan Lv, Kairui Qiu, Tianxiang Tu, Xiaoxue He, Yuchen Peng, Jinbin Ye, Junhao Fu, Ruzhi Deng, Yuqin Wang, Jinyu Wu, Changbao Liu, Junzhao Zhao, Feng Gu   +12 more
doaj   +1 more source

Frame-Based Editing

Journal of Visual Languages and Sentient Systems, 2017
In introductory programming teaching, block-based editors have become very popular because they offer a number of strong advantages for beginning programmers: They avoid many syntax errors, can display all available instructions for visual selection and encourage experimentation with little requirement for recall. Among proficient programmers, however,
Kölling, Michael, Brown, Neil C. C., Altadmri, Amjad   +2 more
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And now, evidence based editing [PDF]

BMJ, 1995
The third congress on peer review will be in Prague in September 1997 Peer review is slow, expensive, prone to bias, corruptible, and possibly anti-innovatory.1 Yet it is central not only to the production of scientific journals but to all of science. Like democracy it may be an imperfect process, but it is better than the alternatives.2 3 4 Or is it?
R, Smith, D, Rennie
openaire   +2 more sources

Image-based material editing [PDF]

ACM SIGGRAPH 2005 Electronic Art and Animation Catalog, 2005
Photo editing software allows digital images to be blurred, warped or re-colored at the touch of a button. However, it is not currently possible to change the material appearance of an object except by painstakingly painting over the appropriate pixels. Here we present a method for automatically replacing one material with another, completely different
Erum Arif Khan, Erik Reinhard, Roland W. Fleming, Heinrich H. Bülthoff   +3 more
openaire   +9 more sources

A review of application of base editing for the treatment of inner ear disorders

Journal of Bio-X Research, 2020
. The development of applications for the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9) system has increased greatly in recent years, especially in the area of gene therapy by efficient in vivo ...
Xingle Zhao, Zhuoer Sun, Wen Kang, Yong Tao, Hao Wu   +4 more
doaj   +1 more source

Base editing the mammalian genome [PDF]

Methods, 2019
Base editing is a powerful technology that enables programmable conversion of single nucleotides in the mammalian genome. Base editors consist of a partially active Cas9 nuclease (Cas9D10A) tethered to a natural or synthetic DNA modifying enzyme.
Emma M, Schatoff, Maria Paz, Zafra, Lukas E, Dow   +2 more
openaire   +2 more sources

Alternative splicing and extensive RNA editing of human TPH2 transcripts. [PDF]

, 2010
Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT.
Bondy, Brigitta, Bondy, B., Baghai Thomas C., Brigitta Bondy, Peter Zill, Zill, P., Schüle Cornelius, Hammer, P., Grohmann Maik, Büttner, A., Walther Maria, Priller, Josef, Hammer Paul, Baghai, Thomas C., Maik Grohmann, Wolfgang Eisenmenger, Baghai, T., Priller Josef, Josef Priller, Walther, D.J., Eisenmenger, Wolfgang, Bader, Michael, Zill, Peter, Paul Hammer, Hammer, Paul, Rupprecht Rainer, Büttner, Andreas, Michael Bader, Andreas Büttner, Diego J Walther, Cornelius Schüle, Paulmann, Nils, Zill Peter, Bader Michael, Eisenmenger, W., Schüle, Cornelius, Maria Walther, Rainer Rupprecht, Thomas C Baghai, Paulmann Nils, Schuele, C., Walther, Diego J., Rupprecht, R., Nils Paulmann, Baghai, T.C., Eisenmenger Wolfgang, Walther, Maria, Grohmann, M., Bondy Brigitta, Walther Diego J., Bader, M., Priller, J., Paulmann, N., Büttner Andreas, Walther, M., Grohmann, Maik, Rupprecht, Rainer, Schüle, C., Walther, D., Buettner, A.   +59 more
core   +1 more source

Research progress in gene editing technology

Frontiers in Bioscience-Landmark, 2021
As a tool for modifying the genome, gene editing technology has developed rapidly in recent years, especially in the past two years. With the emergence of new gene editing technologies, such as transposon editing tools, numerous advancements have been
Sheng Huang, Yali Yan, Fei Su, Xiaorui Huang, Dandan Xia, Xinxin Jiang, Yinghui Dong, Ping Lv, Fangyuan Chen, Yanwei Lv   +9 more
doaj   +1 more source

Image-based object editing [PDF]

Fourth International Conference on 3-D Digital Imaging and Modeling, 2003. 3DIM 2003. Proceedings., 2004
We examine the problem of editing complex 3D objects. We convert the problem of editing a 3D object of arbitrary size and surface properties to a problem of editing a 2D image. We allow the user to specify edits in both geometry and surface properties from any view and at any resolution they find convenient, regardless of the interactive rendering ...
Holly E. Rushmeier, José Gomes, Laurent Balmelli, Fausto Bernardini, Gabriel Taubin   +4 more
openaire   +2 more sources

sgBE: a structure-guided design of sgRNA architecture specifies base editing window and enables simultaneous conversion of cytosine and adenosine

Genome Biology, 2020
We present a base editing system, in which base editors are attached to different sites of sgRNA scaffold (sgBE). Each independent sgBE has its own specific editing pattern for a given target site.
Yanhong Wang, Lifang Zhou, Rui Tao, Nan Liu, Jie Long, Fengming Qin, Wenling Tang, Yang Yang, Qiang Chen, Shaohua Yao   +9 more
doaj   +1 more source