Results 51 to 60 of about 515,050 (293)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

CRISPR-dCas9 mediated cytosine deaminase base editing in bacillus subtilis [PDF]

, 2020
Base editing technology based on clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9) is a recent addition to the family of CRISPR technologies.
Yu, Sili, Rosser, Susan J., Wang, Yu, Price, Marcus A., Ni, Xiaomeng, Liu, Yang, Wang, Meng, Bi, Changhao, Guo, Yanmei   +8 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

CRISPR/Cas9 nickase-mediated cytosine base editing in Trichoderma koningiopsis

Mycology
Base editors are regarded as reliable and precise editing tools due to their ability to efficiently and accurately modify the target genes without inducing double-strand breaks (DSBs).
Yushi Fu, Yuxia Duan, Yongpeng Yao, Yuanyuan Pan, Zhaoqing Zeng, Wenying Zhuang, Gang Liu   +6 more
doaj   +1 more source

Perception-based image editing [PDF]

2009 XXII International Symposium on Information, Communication and Automation Technologies, 2009
Image editing and post-processing techniques have matured over the years, making it difficult (verging on impossi­ble) to assess whether an image has been digitally enhanced or doctored somehow. However, complex manipulations still rely on skilled user input, painstakingly painting over pixels.
openaire   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Improved Dual Base Editor Systems (iACBEs) for Simultaneous Conversion of Adenine and Cytosine in the Bacterium Escherichia coli

mBio, 2023
Genome-editing (GE) techniques like base editing are ideal for introducing novel gain-of-function mutations and in situ protein evolution. Features of base editors (BEs) such as higher efficacy, relaxed protospacer adjacent motif (PAM), and a broader ...
Rahul Mahadev Shelake, Dibyajyoti Pramanik, Jae-Yean Kim   +2 more
doaj   +1 more source

Edition Schemes Based on BSE [PDF]

, 2005
Edition is an important and useful task in supervised classification specifically for instance-based classifiers because edition discards from the training set those useless or harmful objects for the classification accuracy and it helps to reduce the size of the original training sample and to increase both the classification speed and accuracy.
José Arturo Olvera-López, José Francisco Martínez Trinidad, Jesús Ariel Carrasco-Ochoa   +2 more
openaire   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing

, 2023
openLa distrofia muscolare di Duchenne (DMD) è una malattia genetica rara e mortale, causata dalla mancanza di distrofina. Le mutazioni nel gene DMD, localizzato nel cromosoma X, sono trasmesse in modo recessivo legato al sesso; in particolare, una ...
DE ANTONI, NOEMI
core